Role of photodynamic therapy in psoriasis: a brief review.
Humans; Photochemotherapy/*methods/trends; Psoriasis/*drug therapy
BACKGROUND AND PURPOSE: Photodynamic therapy (PDT) is a light treatment modality which involves either systemic or local application of a photosensitizing compound, which preferentially deposits in the target cells, and is then followed by selective illumination of the lesion with visible light. The purpose of this study was to review the literature to examine the success, side effects, and different protocols used thus far to treat psoriasis using PDT. METHODS: A thorough review of the literature was performed and analyzed. RESULTS AND CONCLUSIONS: After a thorough review of the literature, PDT remains a potential treatment for psoriasis. Clinical improvement has been observed in most studies. The major limiting factor seen in many of the studies was the side effect of pain and burning sensations associated with PDT. This highlights the need for other photosensitizers with better tolerability profiles.
Tandon Yasmeen K; Yang Marjorie F; Baron Elma D
Photodermatology, photoimmunology & photomedicine
2008
2008-10
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
<a href="http://doi.org/10.1111/j.1600-0781.2008.00376.x" target="_blank" rel="noreferrer noopener">10.1111/j.1600-0781.2008.00376.x</a>
A histologic review of 27 patients with lichen planopilaris.
Adult; Aged; Alopecia/etiology/*pathology; Biopsy; Cicatrix/etiology/*pathology; Female; Humans; Lichen Planus/complications/diagnosis/*pathology; Male; Middle Aged; Retrospective Studies; Scalp Dermatoses/diagnosis/*pathology; Scalp/*pathology
BACKGROUND: Lichen planopilaris (LPP) is a potential trichologic emergency that can result in permanent scarring alopecia. Histopathology is a key component of the diagnostic work-up. OBJECTIVE: To identify the key histologic features that characterize LPP in order to facilitate diagnosis, ultimately leading to improved patient outcomes. METHODS: Scalp biopsy specimens from 27 confirmed cases of LPP were reviewed in a blinded fashion to determine diagnostically helpful histologic features. RESULTS: Absence of arrector pili muscles and sebaceous glands, a perivascular and perifollicular lymphocytic infiltrate in the reticular dermis and mucinous perifollicular fibroplasia within the upper dermis with absence of interfollicular mucin, and superficial perifollicular wedge-shaped scarring were characterizing features. LIMITATIONS: Sample size was limited, given that biopsy specimens were taken from lesions at varying stages of evolution and findings vary with disease stage. CONCLUSIONS: This study confirms many previously reported histologic features and highlights new characterizing features of mucinous perifollicular fibroplasia.
Tandon Yasmeen K; Somani Najwa; Cevasco Nathaniel C; Bergfeld Wilma F
Journal of the American Academy of Dermatology
2008
2008-07
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
<a href="http://doi.org/10.1016/j.jaad.2008.03.007" target="_blank" rel="noreferrer noopener">10.1016/j.jaad.2008.03.007</a>