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Text
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URL Address
<a href="http://doi.org/10.1016/j.ejpb.2019.12.012" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.ejpb.2019.12.012</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
ISSN
1873-3441
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<a href="http://ezproxy.neomed.idm.oclc.org/login?url=http://doi.org/10.1016/j.ejpb.2019.12.012" target="_blank" rel="noreferrer noopener">NEOMED Full-text Holding (if available) - Proxy DOI: 10.1016/j.ejpb.2019.12.012</a>
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Update Year & Number
January 2020 Update
NEOMED College
NEOMED College of Graduate Studies
NEOMED Department
NEOMED Student Publications; NEOMED College of Graduate Studies Student
Dublin Core
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Title
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Phosphatidylserine targeting peptide-functionalized pH sensitive mixed micelles for enhanced anti-tumor drug delivery
Publisher
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European Journal of Pharmaceutics and Biopharmaceutics: Official Journal of Arbeitsgemeinschaft Fur Pharmazeutische Verfahrenstechnik e.V
Date
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2019
2019-12-30
Subject
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Drug delivery; pH-sensitive mixed micelles; Phosphatidylserine; Targeted peptide
Creator
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Guan Siyu; Zhang Qianqian; Bao Jianwei; Duan Tijie; Hu Rongfeng; Czech Tori; Tang Jihui
Description
An account of the resource
In recent decades, targeted drug delivery systems (TDDS) have been widely used as an ideal method of improving therapeutic effects and reducing systemic side effects of chemotherapeutic agents. Historically, a handful of methods have been developed to further improve the targeting ability of delivery systems. Thus, in this study, two methods, taking advantage of tumor characteristics, were used for the creation of a multi-targeted delivery system. The first was the fabrication of pH-sensitive micelles, lending the ability to increase drug release by exploiting the acidic tumor environment. The second method was through utilization of the surface-exposed phosphatidylserine (PS) of tumors, which is normally found in the inner leaflet in healthy cells. Using PS as a target site, PS binding peptide (PSBP-6) was conjugated to pH-sensitive mixed micelles, (consisting of poly (ethylene glycol)-b-poly (D, L-lactide) (PEG-PDLLA) and poly (ethylene glycol)-b-poly (L-histidine) (PEG-PHIS)). After successful preparation of micelles, paclitaxel (PTX), a common chemotherapeutic agent, was selected to measure drug loading capacity and encapsulation efficiency, showing 7.9% and 83.5%, respectively. The in vitro release of PTX from mixed micelles at pH 5.0, 6.5, and 7.4 was 78.1, 56.8, and 51.4%, respectively, indicating acid-triggered drug release. The PSBP-6-modified, mixed micelles exhibited significantly enhanced in vitro cytotoxicity and demonstrated more efficient cellular uptake compared to unmodified mixed micelles in the HeLa cell line. Moreover, pharmacokinetic, in vivo biodistribution, and fluorescence imaging studies showed that PSBP-6-PEG-PDLLA/PEG-PHIS mixed micelles provide prolonged time in blood circulation and enhanced tumor accumulation. These results suggest that the use of PS as a novel targeting site is advantageous, and that these new multi-targeted mixed micelles show great potential for realization of broad prospects in the targeted treatment of tumors for chemotherapeutic delivery.
Identifier
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<a href="http://doi.org/10.1016/j.ejpb.2019.12.012" target="_blank" rel="noreferrer noopener">10.1016/j.ejpb.2019.12.012</a>
PMID: 31899369
Format
The file format, physical medium, or dimensions of the resource
Journal Article
2019
Bao Jianwei
Czech Tori
Drug delivery
Duan Tijie
European Journal of Pharmaceutics and Biopharmaceutics: Official Journal of Arbeitsgemeinschaft Fur Pharmazeutische Verfahrenstechnik e.V
Guan Siyu
Hu Rongfeng
January 2020 Update
Journal Article
NEOMED College of Graduate Studies Student
NEOMED Student Publications
pH-sensitive mixed micelles
Phosphatidylserine
Tang Jihui
Targeted peptide
Zhang Qianqian
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.2174/1389200220666191003161114" target="_blank" rel="noreferrer noopener">http://doi.org/10.2174/1389200220666191003161114</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
ISSN
1875-5453
Search for Full-text
Locate full-text within NEOMED Library's e-journal collections
<a href="http://ezproxy.neomed.idm.oclc.org/login?url=http://doi.org/10.2174/1389200220666191003161114" target="_blank" rel="noreferrer noopener">NEOMED Full-text Holding (if available) - Proxy DOI: 10.2174/1389200220666191003161114</a>
<p>Users with a NEOMED Library login can search for full-text journal articles at the following url: <a href="https://libraryguides.neomed.edu/home">https://libraryguides.neomed.edu/home</a></p>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
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Recognition Sites for Cancer-Targeting Durg Delivery Systems
Publisher
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Current Drug Metabolism
Date
A point or period of time associated with an event in the lifecycle of the resource
2019
2019-10-03
Subject
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Nanoparticles; tumor; ligand; Recognition sites; targeted drug delivery system
Creator
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Guan Siyu; Zhang Qianqian; Bao Jianwei; Hu Rongfeng; Czech Tori; Tang Jihui
Description
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BACKGROUND: Target-homing drug delivery systems are now gaining significant traction for use as novel therapeutic approaches in antitumor targeting for cancer therapy. Numerous targeted drug delivery systems have been designed to improve the targeting effects because these systems can display a range of favorable properties. Thus, providing suitable characteristics for clinical applicability of anticancer drugs, such as increasing the solubility, and improving the drug distribution at target sites. The majority of these targeting systems are designed with respect to differences between cancerous and normal tissues, for instance, the low pH of tumor tissues or overexpressed receptors on tumor cell membranes. Because of the growing number of targeting possibilities, it is important to know the tumor-specific recognition strategies for designing novel, targeted, drug delivery systems. Herein, we will identify and summarize literature pertaining to various recognition sites for optimizing the design of targeted drug delivery systems to augment current chemotherapeutic approaches. OBJECTIVE: This review focuses on identification of the recognition sites for developing targeted drug delivery systems for use in cancer therapeutics. METHOD: We have reviewed and compiled cancer-specific recognition sites and their abnormal characteristics within tumor tissues (low pH, high glutathione, targetable receptors, etc.), tumor cells (receptor overexpression or tumor cell membrane changes) and tumor cell organelles (nuclear and endoplasmic reticular dysregulation) utilizing existing scientific literature. Moreover, we have highlighted the design of some targeted drug delivery systems that can be used as homing tools for these recognition sites. RESULTS AND CONCLUSION: Targeted drug delivery systems are a promising therapeutic approach for tumor chemotherapy. Additional research focused on finding novel recognition sites, and subsequent development of targeting moieties for use with drug delivery systems will aid in the evaluation and clinical application of new and improved chemotherapeutics.
Identifier
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<a href="http://doi.org/10.2174/1389200220666191003161114" target="_blank" rel="noreferrer noopener">10.2174/1389200220666191003161114</a>
PMID: 31580248
Format
The file format, physical medium, or dimensions of the resource
Journal Article
2019
Anhui Medical University
Bao Jianwei
Current Drug Metabolism
Czech Tori
Department of Pharmaceutical Sciences
Guan Siyu
Hu Rongfeng
Journal Article
ligand
Nanoparticles
NEOMED College of Pharmacy
NEOMED College of Pharmacy Student
November 2019 Update
Recognition sites
Tang Jihui
targeted drug delivery system
Tumor
Zhang Qianqian