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Text
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<a href="http://doi.org/10.1186/s13024-017-0216-6" target="_blank" rel="noreferrer noopener">http://doi.org/10.1186/s13024-017-0216-6</a>
Pages
74–74
Issue
1
Volume
12
Dublin Core
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Title
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TREM2 deficiency exacerbates tau pathology through dysregulated kinase signaling in a mouse model of tauopathy.
Publisher
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Molecular neurodegeneration
Date
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2017
2017-10
Subject
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*Alzheimers disease; *Immunity; *Inflammation; *Tauopathy; *TREM2; Animal; Animals; Disease Models; Humans; Immunologic/*deficiency; Inbred C57BL; Membrane Glycoproteins/*deficiency; Mice; Microglia/metabolism; Protein Kinases/*metabolism; Receptors; Signal Transduction/physiology; tau Proteins/*metabolism; Tauopathies/metabolism/*pathology; Transgenic
Creator
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Bemiller Shane M; McCray Tyler J; Allan Kevin; Formica Shane V; Xu Guixiang; Wilson Gina; Kokiko-Cochran Olga N; Crish Samuel D; Lasagna-Reeves Cristian A; Ransohoff Richard M; Landreth Gary E; Lamb Bruce T
Description
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BACKGROUND: Genetic variants of the Triggering Receptor Expressed on Myeloid Cells-2 (TREM2) confer increased risk of developing late-onset Alzheimer's Disease (LOAD) and other neurodegenerative disorders. Recent studies provided insight into the multifaceted roles of TREM2 in regulating extracellular beta-amyloid (Abeta) pathology, myeloid cell accumulation, and inflammation observed in AD, yet little is known regarding the role of TREM2 in regulating intracellular microtubule associated protein tau (MAPT; tau) pathology in neurodegenerative diseases and in AD, in particular. RESULTS: Here we report that TREM2 deficiency leads to accelerated and exacerbated hyperphosphorylation and aggregation of tau in a humanized mouse model of tauopathy. TREM2 deficiency also results, indirectly, in dramatic widespread dysregulation of neuronal stress kinase pathways. CONCLUSIONS: Our results suggest that deficiency of microglial TREM2 leads to heightened tau pathology coupled with widespread increases in activated neuronal stress kinases. These findings offer new insight into the complex, multiple roles of TREM2 in regulating Abeta and tau pathologies.
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<a href="http://doi.org/10.1186/s13024-017-0216-6" target="_blank" rel="noreferrer noopener">10.1186/s13024-017-0216-6</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Alzheimers disease
*Immunity
*Inflammation
*Tauopathy
*TREM2
2017
Allan Kevin
Animal
Animals
Bemiller Shane M
Crish Samuel D
Department of Pharmaceutical Sciences
Disease Models
Formica Shane V
Humans
Immunologic/*deficiency
Inbred C57BL
Kokiko-Cochran Olga N
Lamb Bruce T
Landreth Gary E
Lasagna-Reeves Cristian A
McCray Tyler J
Membrane Glycoproteins/*deficiency
Mice
Microglia/metabolism
Molecular neurodegeneration
NEOMED College of Pharmacy
Protein Kinases/*metabolism
Ransohoff Richard M
Receptors
Signal Transduction/physiology
tau Proteins/*metabolism
Tauopathies/metabolism/*pathology
Transgenic
Wilson Gina
Xu Guixiang