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URL Address
<a href="http://doi.org/10.1080/01635581.2013.767367" target="_blank" rel="noreferrer noopener">http://doi.org/10.1080/01635581.2013.767367</a>
Pages
329–344
Issue
3
Volume
65
Dublin Core
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Title
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Chemopreventive and therapeutic potential of tea polyphenols in hepatocellular cancer.
Publisher
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Nutrition and cancer
Date
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2013
1905-07
Subject
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*Anticarcinogenic Agents; Animal; Animals; Anti-Inflammatory Agents; Antioxidants; Biological Availability; Biological Markers; Carcinoma; Catechin/administration & dosage/analogs & derivatives; Chemoprevention; Disease Models; Hepatocellular – Physiopathology; Hepatocellular – Prevention and Control; Hepatocellular – Therapy; Human; Humans; In Vitro Studies; In Vivo Studies; Liver Neoplasms/*drug therapy/*prevention & control; Mice; Neoplasms – Prevention and Control; Nutrition; Outcomes (Health Care); Phenols – Therapeutic Use; Polyphenols/*administration & dosage/pharmacology; Tea – Therapeutic Use; Tea/*chemistry; Xenograft Model Antitumor Assays
Creator
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Darvesh Altaf S; Bishayee Anupam
Description
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The prophylactic and therapeutic properties of tea have been attributed to green tea catechins and black tea theaflavins besides several other polyphenolic compounds. Tea polyphenols possess potent antioxidant and antiinflammatory properties and modulate several signaling pathways. These biochemical facets of tea polyphenols are responsible for its anticancer properties. Several lethal cancers, such as liver cancer, develop within a background of oxidative stress and inflammation. Liver cancer, also known as hepatocellular carcinoma (HCC), has been shown to occur throughout the world including Asia, Africa, Western Europe, and the United States. Phytochemicals, such as tea polyphenols, provide an effective and promising alternative for the chemoprevention and treatment of HCC. In this article, we systematically review, for the first time, the effects of tea polyphenols in the preclinical in vitro and in vivo HCC models. The review also examines, in critical detail, the biochemical mechanisms involved in the chemopreventive and antineoplastic effects of tea polyphenols in hepatic cancer. Finally, we highlight the role of synergy, bioavailability and pharmacokinetics of tea polyphenols, current status of clinical trials, discuss future directions, and comment on the future challenges involved in the effective use of tea polyphenols for the prevention and management of liver cancer.
Identifier
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<a href="http://doi.org/10.1080/01635581.2013.767367" target="_blank" rel="noreferrer noopener">10.1080/01635581.2013.767367</a>
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*Anticarcinogenic Agents
2013
Animal
Animals
Anti-Inflammatory Agents
Antioxidants
Biological Availability
Biological Markers
Bishayee Anupam
Carcinoma
Catechin/administration & dosage/analogs & derivatives
Chemoprevention
Darvesh Altaf S
Department of Pharmaceutical Sciences
Disease Models
Hepatocellular – Physiopathology
Hepatocellular – Prevention and Control
Hepatocellular – Therapy
Human
Humans
In Vitro Studies
In Vivo Studies
Liver Neoplasms/*drug therapy/*prevention & control
Mice
NEOMED College of Pharmacy
Neoplasms – Prevention and Control
nutrition
Nutrition and cancer
Outcomes (Health Care)
Phenols – Therapeutic Use
Polyphenols/*administration & dosage/pharmacology
Tea – Therapeutic Use
Tea/*chemistry
Xenograft Model Antitumor Assays