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<a href="http://doi.org/10.1016/j.neuroscience.2009.02.036" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.neuroscience.2009.02.036</a>
Pages
103–114
Issue
1
Volume
160
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Title
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Sources of cholinergic input to the inferior colliculus.
Publisher
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Neuroscience
Date
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2009
2009-04
Subject
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Acetylcholine/*metabolism; Animals; Choline O-Acetyltransferase/metabolism; Female; Guinea Pigs; Immunohistochemistry; Inferior Colliculi/*anatomy & histology; Male; Neural Pathways/anatomy & histology/metabolism; Pedunculopontine Tegmental Nucleus/anatomy & histology/metabolism; Photomicrography; Tegmentum Mesencephali/*anatomy & histology/*metabolism
Creator
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Motts S D; Schofield B R
Description
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We combined retrograde tracing with immunohistochemistry for choline acetyltransferase to identify the source of cholinergic input to the inferior colliculus (IC) in guinea pigs. Injection of a retrograde tracer into one IC labeled cells in many brainstem nuclei. Retrogradely-labeled cells that were also immunoreactive for choline acetyltransferase were identified in two nuclei in the midbrain tegmentum: the pedunculopontine tegmental nucleus (PPT) and the laterodorsal tegmental nucleus (LDT). More PPT and LDT cells project ipsilaterally than contralaterally to the IC and, on both sides, there are more projecting cells in the PPT than in the LDT. Double-labeled cells were not found in any other brainstem nucleus. A common feature of cholinergic cells in PPT and LDT is collateral projections to multiple targets. We placed different retrograde tracers into each IC to identify cells in PPT and LDT that project to both ICs. In both PPT and LDT, a substantial proportion (up to 57%) of the immunoreactive cells that contained tracer from the contralateral IC also contained tracer from the ipsilateral IC. We conclude that acetylcholine in the IC originates from the midbrain tegmental cholinergic nuclei: PPT and LDT. These nuclei are known to participate in arousal, the sleep/wake cycle and prepulse inhibition of acoustic startle. It is likely that the cholinergic input to the IC is directly associated with these functions.
Identifier
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<a href="http://doi.org/10.1016/j.neuroscience.2009.02.036" target="_blank" rel="noreferrer noopener">10.1016/j.neuroscience.2009.02.036</a>
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2009
Acetylcholine/*metabolism
Animals
Choline O-Acetyltransferase/metabolism
Department of Anatomy & Neurobiology
Female
Guinea Pigs
Immunohistochemistry
Inferior Colliculi/*anatomy & histology
Male
Motts S D
NEOMED College of Medicine
Neural Pathways/anatomy & histology/metabolism
Neuroscience
Pedunculopontine Tegmental Nucleus/anatomy & histology/metabolism
Photomicrography
Schofield B R
Tegmentum Mesencephali/*anatomy & histology/*metabolism