1
40
1
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.ygcen.2020.113492" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.ygcen.2020.113492</a>
Pages
113492
Volume
293
ISSN
0016-6480
Search for Full-text
Locate full-text within NEOMED Library's e-journal collections
<a href="http://neomed.idm.oclc.org/login?url=http://doi.org/10.1016/j.ygcen.2020.113492" target="_blank" rel="noreferrer noopener">NEOMED Full-text Holding (if available) - Proxy DOI: 10.1016/j.ygcen.2020.113492</a>
<p>Users with a NEOMED Library login can search for full-text journal articles at the following url: <a href="https://libraryguides.neomed.edu/home">https://libraryguides.neomed.edu/home</a></p>
Update Year & Number
June 2020 Update II
NEOMED College
NEOMED College of Medicine
NEOMED Department
NEOMED Student Publications
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Intramuscular antagonism of the G-protein coupled estrogen receptor 1 partially affects dimorphic characteristics of the syrinx, but is ineffective within the neural song circuit of zebra finches
Publisher
An entity responsible for making the resource available
General and Comparative Endocrinology
Date
A point or period of time associated with an event in the lifecycle of the resource
2020
2020-07-01
Subject
The topic of the resource
androgen receptor; behavior; brain; control nuclei; Drug delivery; estradiol; Estrogen receptor; expression; GPER1 antagonist; gpr30; growth; Sexual dimorphism; sexual-differentiation; Songbird; Syrinx; system
Creator
An entity primarily responsible for making the resource
Tehrani Mahtab Attarhaie; Veney Sean L
Description
An account of the resource
Within the zebra finch song system, robust sex differences exist that enable singing behavior in males, but not females. Estradiol is a potent contributor to this process, but how and through which receptor(s) it acts is not clear. Historically, pharmacological manipulations of nuclear estrogen receptors have yielded conflicting results possibly due to method of drug delivery. More recently, the membrane bound G-protein coupled estrogen receptor 1 (GPER1) has also been identified as a potential candidate, but its function has not been fully described. To further investigate the role of GPER1, and the importance of the route of drug administration, a specific antagonist (G-15) was intramuscularly administered to zebra finches for 25 days, starting on the day of hatching. G-15 significantly decreased muscle fiber sizes of ventralis and dorsalis in the syrinx of males only. Dimorphic characteristics of the neural song system were unaffected by this manipulation in either sex. These results contrast with a study in which G-15 was intracranially delivered. In males, select song nuclei were decreased in volume, and in females, syrinx muscle fiber size was increased. Together, these results support the hypothesis that estrogens acting through GPER1 influence dimorphic development of the song system, and that method of drug administration is important in this species.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/j.ygcen.2020.113492" target="_blank" rel="noreferrer noopener">10.1016/j.ygcen.2020.113492</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Format
The file format, physical medium, or dimensions of the resource
journalArticle
2020
androgen receptor
Behavior
Brain
control nuclei
Drug delivery
estradiol
estrogen receptor
expression
General and Comparative Endocrinology
GPER1 antagonist
gpr30
growth
journalArticle
June 2020 Update II
NEOMED Postdoc Publications
sexual dimorphism
sexual-differentiation
Songbird
Syrinx
system
Tehrani Mahtab Attarhaie
Veney Sean L