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Text
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<a href="http://doi.org/10.1016/j.jaad.2019.01.050" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.jaad.2019.01.050</a>
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Pages
1664-1670.e1
Issue
6
Volume
80
Dublin Core
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Title
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Linear morphea: Clinical characteristics, disease course, and treatment of the Morphea in Adults and Children cohort
Publisher
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Journal of the American Academy of Dermatology
Date
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2019
2019-06
Subject
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en coup de sabre; linear morphea; localized scleroderma; MAC cohort; Morphea in Adults and Children cohort; Parry-Romberg syndrome; quality of life
Creator
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Kunzler Elaine; Florez-Pollack Stephanie; Teske Noelle; O'Brien Jack; Prasad Smriti; Jacobe Heidi
Description
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BACKGROUND: Prospective, longitudinal studies examining the features of linear morphea are limited. OBJECTIVE: To utilize the Morphea in Adults and Children cohort to determine clinical characteristics, impact on life quality, and disease course of linear morphea in a prospective, longitudinal manner. METHODS: Characteristics of linear morphea versus other subtypes were compared in a cross-sectional manner. Next, linear morphea participants were examined in depth over a 3-year period. RESULTS: Linear morphea was the most common morphea subtype (50.1%, 291/581) in the cohort. Deep involvement was more common in linear (64.3%, 187/291) than other morphea subtypes. Linear morphea participants with deep involvement were more likely to have a limitation in range of motion (28.6%, 55/192) than those without (11.1%, 11/99, P < .001). Adult-onset disease occurred in 32.6% (95/291) of those with linear morphea. Frequency of deep involvement was similar between pediatric (66.8%, 131/196) and adult-onset linear morphea (58.9%, 56/95, P = .19). Quality of life and disease activity scores improved over time, while damage stabilized with treatment. LIMITATIONS: Results of the study are associative, and the University of Texas Southwestern Medical Center is a tertiary referral center. CONCLUSION: A substantial number of linear morphea patients have adult-onset disease. In all age groups, linear morphea with deep involvement was associated with functional limitations.
Identifier
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<a href="http://doi.org/10.1016/j.jaad.2019.01.050" target="_blank" rel="noreferrer noopener">10.1016/j.jaad.2019.01.050</a>
2019
en coup de sabre
Florez-Pollack Stephanie
Jacobe Heidi
Journal of the American Academy of Dermatology
June 2019 Update
Kunzler Elaine
linear morphea
localized scleroderma
MAC cohort
Morphea in Adults and Children cohort
NEOMED College of Medicine
NEOMED College of Medicine Student
NEOMED Student Publications
O'Brien Jack
Parry-Romberg syndrome
Prasad Smriti
Quality of Life
Teske Noelle