1
40
4
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Pages
34–39
Issue
1
Volume
277
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Testosterone causes direct relaxation of rat thoracic aorta.
Publisher
An entity responsible for making the resource available
The Journal of pharmacology and experimental therapeutics
Date
A point or period of time associated with an event in the lifecycle of the resource
1996
1996-04
Subject
The topic of the resource
Female; Male; Animals; Rats; In Vitro Techniques; Vasodilation/*drug effects; Testosterone/*pharmacology; Phenylephrine/pharmacology; Calcium Channels/drug effects; Dose-Response Relationship; Drug; Sprague-Dawley; Aorta; Endothelium; Thoracic/*drug effects/physiology; Vascular/physiology
Creator
An entity primarily responsible for making the resource
Costarella C E; Stallone J N; Rutecki G W; Whittier F C
Description
An account of the resource
Several recent studies have provided evidence that gonadal steroid hormones can exert acute (nongenomic) effects on both neural and vascular tissues. This study examines the acute effects of testosterone (T) on vascular reactivity of the rat thoracic aorta. Aortic rings from male Sprague-Dawley (SD) rats with (+ENDO) and without (-ENDO) endothelium were prepared for isometric tension recording. In (+ENDO) male aortae precontracted with phenylephrine (PE), T produced dose-dependent relaxation from 25 microM (30.3 +/- 7.1%) to 300 microM (99.4 +/- 0.4%), whereas T vehicle (\textless or = 0.5% ethanol) had no effect. Pretreatment of (+ENDO) aortae with T (50 microM; 10 min) attenuated subsequent contractile responses to PE. Both maximal contraction and sensitivity to PE were reduced by T. Pretreatment of (+ENDO) aortae with both T and N omega-nitro-L-arginine methyl ester (250 microM) reversed in part the attenuating effects of T alone; however, both maximal response and sensitivity to PE were still reduced compared to control rings (without T or N omega-nitro-L-arginine methyl ester). Pretreatment of (-ENDO) aortae with T reduced sensitivity to PE, but had no effect on maximal contraction. T pretreatment (50 microM; 10 min) of both (+ENDO) female SD aortae and (+ENDO) male testicular-feminized rat aortae reduced maximal contraction and sensitivity to PE in both groups to a similar extent as in (+ENDO) male SD aortae. These data suggest that T has a direct vasodilating effect on the rat aorta, which involves endothelium-dependent (enhanced NO release) and -independent mechanisms and is gender- and intracellular androgen receptor-independent.
Rights
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1996
Animals
Aorta
Calcium Channels/drug effects
Costarella C E
Department of Internal Medicine
Dose-Response Relationship
Drug
Endothelium
Female
In Vitro Techniques
Male
NEOMED College of Medicine
Phenylephrine/pharmacology
Rats
Rutecki G W
Sprague-Dawley
Stallone J N
Testosterone/*pharmacology
The Journal of pharmacology and experimental therapeutics
Thoracic/*drug effects/physiology
Vascular/physiology
Vasodilation/*drug effects
Whittier F C
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1196/annals.1369.025" target="_blank" rel="noreferrer noopener">http://doi.org/10.1196/annals.1369.025</a>
Pages
282–294
Volume
1074
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Estrogen, testosterone, and methamphetamine toxicity.
Publisher
An entity responsible for making the resource available
Annals of the New York Academy of Sciences
Date
A point or period of time associated with an event in the lifecycle of the resource
2006
2006-08
Subject
The topic of the resource
Animals; Corpus Striatum/drug effects/metabolism; Dopamine Agents/*administration & dosage/toxicity; Drug Interactions; Estrogens/*pharmacology; Female; Male; Methamphetamine/*administration & dosage/toxicity; Mice; Testosterone/*pharmacology
Creator
An entity primarily responsible for making the resource
Dluzen Dean E; McDermott Janet L
Description
An account of the resource
The gonadal steroid hormone, estrogen, can diminish the degree of striatal dopamine depletion resulting from methamphetamine. In this article, we describe the conditions of this estrogen neuroprotection as well as the potential for estrogen and testosterone to enhance methamphetamine-induced neurodegeneration of the nigrostriatal dopaminergic system. When administered prior to a neurotoxic regimen of methamphetamine, estrogen significantly decreases the amount of striatal dopamine depletion in intact or gonadectomized female, but not male, mice. This capacity for estrogen to function as a neuroprotectant can occur quite rapidly, at 30 min prior to methamphetamine administration, and with relatively low doses of estrogen (1 microg estradiol benzoate). Estrogen remains an effective neuroprotectant in neonatally gonadectomized female mice treated with testosterone, but not in female mice that were gonadectomized prior to puberty. Nor does estrogen demonstrate any beneficial effects when administered after methamphetamine. Recent data have indicated some conditions where gonadal steroids can increase the extent of striatal neurodegeneration in response to methamphetamine. Specifically, when some existing perturbation is present in the nigrostriatal dopaminergic system, treatment with estrogen enhances the extent of striatal dopamine depletion to methamphetamine. Similarly, increased striatal dopamine depletion to methamphetamine is observed in gonadectomized male mice treated with testosterone.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1196/annals.1369.025" target="_blank" rel="noreferrer noopener">10.1196/annals.1369.025</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2006
Animals
Annals of the New York Academy of Sciences
Corpus Striatum/drug effects/metabolism
Dluzen Dean E
Dopamine Agents/*administration & dosage/toxicity
Drug Interactions
Estrogens/*pharmacology
Female
Male
McDermott Janet L
Methamphetamine/*administration & dosage/toxicity
Mice
Testosterone/*pharmacology
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0006-8993(95)01566-3" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0006-8993(95)01566-3</a>
Pages
113–118
Issue
1
Volume
715
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Effects of testosterone upon MPTP-induced neurotoxicity of the nigrostriatal dopaminergic system of C57/B1 mice.
Publisher
An entity responsible for making the resource available
Brain research
Date
A point or period of time associated with an event in the lifecycle of the resource
1996
1996-04
Subject
The topic of the resource
*MPTP Poisoning; 1-Methyl-4-phenyl-1; 2; 3; 4-Dihydroxyphenylacetic Acid/metabolism; 6-tetrahydropyridine/*antagonists & inhibitors; Animals; Catecholamines/metabolism; Dopamine Agents/*toxicity; Dopamine/metabolism/*physiology; Female; Inbred C57BL; Male; Mice; Neostriatum/drug effects/metabolism/*pathology; Nervous System Diseases/chemically induced/*pathology/*prevention & control; Olfactory Bulb/drug effects/metabolism; Orchiectomy; Substantia Nigra/drug effects/metabolism/*pathology; Testosterone/*pharmacology
Creator
An entity primarily responsible for making the resource
Dluzen D E
Description
An account of the resource
We have recently reported that treatment of gonadectomized female and male C57/B1 mice with the gonadal steroid hormone, estrogen, reduced nigrostriatal dopaminergic neurotoxicity resulting from the Parkinson's-like inducing agent
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0006-8993(95)01566-3" target="_blank" rel="noreferrer noopener">10.1016/0006-8993(95)01566-3</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*MPTP Poisoning
1-Methyl-4-phenyl-1
1996
2
3
4-Dihydroxyphenylacetic Acid/metabolism
6-tetrahydropyridine/*antagonists & inhibitors
Animals
Brain research
Catecholamines/metabolism
Dluzen D E
Dopamine Agents/*toxicity
Dopamine/metabolism/*physiology
Female
Inbred C57BL
Male
Mice
Neostriatum/drug effects/metabolism/*pathology
Nervous System Diseases/chemically induced/*pathology/*prevention & control
Olfactory Bulb/drug effects/metabolism
Orchiectomy
Substantia Nigra/drug effects/metabolism/*pathology
Testosterone/*pharmacology
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0006-8993(91)91390-m" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0006-8993(91)91390-m</a>
Pages
147–151
Issue
1
Volume
568
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Castration reduces potassium-stimulated norepinephrine release from superfused olfactory bulbs of male rats.
Publisher
An entity responsible for making the resource available
Brain research
Date
A point or period of time associated with an event in the lifecycle of the resource
1991
1991-12
Subject
The topic of the resource
*Orchiectomy; Animals; Inbred Strains; Kinetics; Male; Norepinephrine/*metabolism; Olfactory Bulb/drug effects/*physiology; Potassium/*pharmacology; Rats; Reference Values; Testosterone/*pharmacology
Creator
An entity primarily responsible for making the resource
Guan X B; Dluzen D
Description
An account of the resource
In order to investigate the possible relationship among the olfactory bulb (OB), norepinephrine (NE) and gonadal steroids, we measured NE release from superfused anterior and posterior OB in intact and castrated male rats (Expt. I) as well as in castrated male rats implanted with either empty or testosterone filled silastic capsules (Expt. II). Both basal and potassium (K+ 30 mM)-stimulated release of NE was greater in posterior compared to anterior OB. All groups were responsive to the K+ stimuli showing increases in NE release. The degree of K(+)-stimulated release was significantly greater in intact compared to that of castrated rats. No differences in K(+)-stimulated release were observed between castrated and castrated plus testosterone-treated groups. These results demonstrate that castration of male rats significantly reduces OB noradrenergic responsiveness to K+ stimulation, an effect which was not restored following administration of silastic capsules containing testosterone.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0006-8993(91)91390-m" target="_blank" rel="noreferrer noopener">10.1016/0006-8993(91)91390-m</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Orchiectomy
1991
Animals
Brain research
Dluzen D
Guan X B
Inbred Strains
Kinetics
Male
Norepinephrine/*metabolism
Olfactory Bulb/drug effects/*physiology
Potassium/*pharmacology
Rats
Reference Values
Testosterone/*pharmacology