1 40 3 Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. URL Address <a href="http://doi.org/10.1532/HSF98.20121103" target="_blank" rel="noreferrer noopener">http://doi.org/10.1532/HSF98.20121103</a> Pages E60–69 Issue 2 Volume 16 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Safety and efficacy of cangrelor, an intravenous, short-acting platelet inhibitor in patients requiring coronary artery bypass surgery. Publisher An entity responsible for making the resource available The heart surgery forum Date A point or period of time associated with an event in the lifecycle of the resource 2013 2013-04 Subject The topic of the resource Adult; Female; Humans; Male; Middle Aged; Aged; Treatment Outcome; Prevalence; United States/epidemiology; Risk Assessment; Adenosine Monophosphate/administration & dosage/*analogs & derivatives; Blood Transfusion/*statistics & numerical data; Coronary Artery Bypass/*statistics & numerical data; Drug-Related Side Effects and Adverse Reactions/epidemiology; Placebo Effect; Platelet Aggregation Inhibitors/administration & dosage; Postoperative Hemorrhage/*epidemiology/*prevention & control; Premedication/*statistics & numerical data; Purinergic P2Y Receptor Antagonists/administration & dosage; Pyridines/*administration & dosage; Injections; 80 and over; Intravenous; Administration; Drug Therapy; Oral; Combination/statistics & numerical data Creator An entity primarily responsible for making the resource Firstenberg Michael S; Dyke Cornelius M; Angiolillo Dominick J; Ramaiahm Chandrashekar; Price Matthew; Brtko Miroslav; Welsby Ian; Chandna Harish; Holmes David R; Voeltz Michele; Tummala Pradyumna; Hutyra Martin; Manoukian Steven V; Prats Jayne; Todd Meredith; Liu Tiepu; Chronos Nicholas; Dietrich Markus; Montalescot Gilles; Cannon Louis A; Topo Eric J Description An account of the resource OBJECTIVE: Oral P2Y(1)(2) platelet receptor inhibitors are a cornerstone of reducing complications in patients with acute coronary syndromes or coronary stents. Guidelines advocate discontinuing treatment with P2Y(1)(2) platelet receptor inhibitors before surgery. Cangrelor, a short-acting, reversible, intravenously administered P2Y(1)(2) platelet inhibitor is effective in achieving appropriate platelet inhibition in patients who are awaiting coronary artery bypass grafting (CABG) and require P2Y(1)(2) inhibition. The objective of this study was to assess the effects of preoperative cangrelor on the incidence of perioperative complications, which are currently unknown. METHODS: Patients (n = 210) requiring preoperative clinical administration of thienopyridine therapy were randomized in a multicenter, double-blinded study to receive cangrelor or placebo while awaiting CABG after discontinuation of the thienopyridine. Optimal platelet reactivity, which was defined as \textless240 P2Y(1)(2) platelet reaction units, was measured with serial point-of-care testing (VerifyNow). Pre- and postoperative outcomes, bleeding values, and transfusion rates were compared. To quantify potential risk factors for bleeding, we developed a multivariate logistic model. RESULTS: The differences between the groups in bleeding and perioperative transfusion rates were not significantly different. The rate of Identifier An unambiguous reference to the resource within a given context <a href="http://doi.org/10.1532/HSF98.20121103" target="_blank" rel="noreferrer noopener">10.1532/HSF98.20121103</a> Rights Information about rights held in and over the resource Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s). 2013 80 and over Adenosine Monophosphate/administration & dosage/*analogs & derivatives Administration Adult Aged Angiolillo Dominick J Blood Transfusion/*statistics & numerical data Brtko Miroslav Cannon Louis A Chandna Harish Chronos Nicholas Combination/statistics & numerical data Coronary Artery Bypass/*statistics & numerical data Dietrich Markus Drug Therapy Drug-Related Side Effects and Adverse Reactions/epidemiology Dyke Cornelius M Female Firstenberg Michael S Holmes David R Humans Hutyra Martin Injections Intravenous Liu Tiepu Male Manoukian Steven V Middle Aged Montalescot Gilles Oral Placebo Effect Platelet Aggregation Inhibitors/administration & dosage Postoperative Hemorrhage/*epidemiology/*prevention & control Prats Jayne Premedication/*statistics & numerical data Prevalence Price Matthew Purinergic P2Y Receptor Antagonists/administration & dosage Pyridines/*administration & dosage Ramaiahm Chandrashekar Risk Assessment The heart surgery forum Todd Meredith Topo Eric J Treatment Outcome Tummala Pradyumna United States/epidemiology Voeltz Michele Welsby Ian Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. URL Address <a href="http://doi.org/10.1532/hsf.2167" target="_blank" rel="noreferrer noopener">http://doi.org/10.1532/hsf.2167</a> Pages E507–E512 Issue 6 Volume 21 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Torsades de Pointes in Intravenous Drug Abuse-Associated Infective Endocarditis. Publisher An entity responsible for making the resource available The heart surgery forum Date A point or period of time associated with an event in the lifecycle of the resource 2018 2018-12 Subject The topic of the resource Adult; Bacteremia/complications; Female; Heart Valve Prosthesis/*adverse effects; Humans; Postoperative Complications; Torsades de Pointes/*etiology; Tricuspid Valve/*surgery; Endocarditis; Bacterial/*complications/*surgery; Intravenous/*complications; Substance Abuse Creator An entity primarily responsible for making the resource Eapen Sarah; Firstenberg Michael Description An account of the resource Intravenous drug abuse rates in the United States have increased exponentially in recent years. Ohio is one of 5 states with the highest age-adjusted drug overdose death rates, with drug overdose causing 39.1 of every 100,000 deaths. In patients who survive, the associated morbidity poses a significant public health burden. Infective endocarditis, defined as an infection of the endocardium of the heart, is a potentially lethal consequence of bacteremia related to intravenous drug abuse. Methicillin-sensitive Staphylococcus aureus (MSSA) is the most commonly implicated organism and may affect the tricuspid valve. Indications for surgery include failure of medical management, worsening embolization, heart failure, and arrhythmias-typically bradyarrhythmias from infectious extension into the conduction system. Vegetation size and type of infection, such as drug-resistance pattern, fungal infection, and presence of prosthetic material, are becoming known risk factors for complications. Studies have demonstrated that early surgery tends to have a better prognosis than delayed intervention. Established guidelines for right-sided surgery are slowly evolving. Tricuspid valve surgery is becoming more common in these cases, but there is known risk for heart block owing to proximity of the conduction system to the tricuspid valve annulus. If patients develop complete heart block postoperatively, pacemaker placement may be indicated. There may be reluctance to implantation because of the risk of device infection with infective endocarditis. In addition, many may recover conduction as infection and edema resolve. Generally, bradyarrhythmias are well tolerated. However, we present 2 cases of torsades de pointes related to post-tricuspid-valve-replacement bradyarrhythmia. Torsades de pointes is a potentially lethal form of polymorphic ventricular arrhythmia associated with QT interval prolongation. Post-tricuspid-valve- replacement mortality may be secondary to induced lethal ventricular arrhythmias. Identifier An unambiguous reference to the resource within a given context <a href="http://doi.org/10.1532/hsf.2167" target="_blank" rel="noreferrer noopener">10.1532/hsf.2167</a> Rights Information about rights held in and over the resource Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s). 2018 Adult Bacteremia/complications Bacterial/*complications/*surgery Eapen Sarah Endocarditis Female Firstenberg Michael Heart Valve Prosthesis/*adverse effects Humans Intravenous/*complications Postoperative Complications Substance Abuse The heart surgery forum Torsades de Pointes/*etiology Tricuspid Valve/*surgery Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. URL Address <a href="http://doi.org/10.1532/hsf.2057" target="_blank" rel="noreferrer noopener">http://doi.org/10.1532/hsf.2057</a> Pages E485–E488 Issue 6 Volume 21 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Extracorporeal Membrane Oxygenation in Extreme Obesity: A Case Report and Review of the Literature. Publisher An entity responsible for making the resource available The heart surgery forum Date A point or period of time associated with an event in the lifecycle of the resource 2018 2018-11 Subject The topic of the resource Adult; Female; Humans; Obesity; *Extracorporeal Membrane Oxygenation; Pneumonia; Respiratory Distress Syndrome; Adult/*complications/etiology/*therapy; Aspiration/complications; Morbid/*complications Creator An entity primarily responsible for making the resource Azouz Vitali; Hill Sarah; Firstenberg Michael Description An account of the resource The use of extracorporeal membrane oxygenation (ECMO) in the treatment of acute respiratory distress syndrome (ARDS) has been described as early as 1972 [Hill 1972]. Though a subsequent randomized trial showed no survival benefit over conventional mechanical ventilation [Zapol 1979], protective ventilation strategies and evolving extracorporeal technology improvements have led to a resurgence in the use of ECMO for patients with ARDS. The most recent randomized clinical trial, Conventional Ventilation or ECMO for Severe Adult Respiratory Failure (CESAR), showed a significant mortality reduction in ARDS patients who were treated with ECMO [Peek 2009]. The results of the trial have led some to believe that the widespread adoption of ECMO as a feasible treatment for severe respiratory failure is forthcoming [MacLaren 2012; Del Sorbo 2014]. As the use of ECMO continues to increase, clinicians must be aware of the extremes in patient characteristics for which therapy might be considered reasonable. For example, many studies focus on the limited benefit of advanced therapies, such as ECMO, in the elderly [Salna 2014]. However, there is a paucity of literature on using veno-venous extracorporeal membrane oxygenation (VV ECMO) to treat ARDS in patients with extremity obesity [Ull 2015; Belliato 2016; Kadakia 2017]-a population that is often inherently discriminated against with regards to advanced medical and surgical therapies because of the practical challenges of treating someone of great size as well as the inherent social (and professional) biases against such patients. This case demonstrates application of ECMO in a patient with an extreme body mass index (BMI) and confirms the successful use of ECMO in this BMI patient population. Identifier An unambiguous reference to the resource within a given context <a href="http://doi.org/10.1532/hsf.2057" target="_blank" rel="noreferrer noopener">10.1532/hsf.2057</a> Rights Information about rights held in and over the resource Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s). *Extracorporeal Membrane Oxygenation 2018 Adult Adult/*complications/etiology/*therapy Aspiration/complications Azouz Vitali Female Firstenberg Michael Hill Sarah Humans Morbid/*complications Obesity Pneumonia Respiratory Distress Syndrome The heart surgery forum