1
40
3
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1369/jhc.4A6455.2004" target="_blank" rel="noreferrer noopener">http://doi.org/10.1369/jhc.4A6455.2004</a>
Pages
1665–1674
Issue
12
Volume
52
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Characterization of vascular endothelial growth factor (VEGF) in the uterine cervix over pregnancy: effects of denervation and implications for cervical ripening.
Publisher
An entity responsible for making the resource available
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society
Date
A point or period of time associated with an event in the lifecycle of the resource
2004
2004-12
Subject
The topic of the resource
Female; Animals; Immunohistochemistry; Pregnancy; Rats; Microcirculation; Phosphorylation; Down-Regulation; Enzyme-Linked Immunosorbent Assay; Reverse Transcriptase Polymerase Chain Reaction; Cervical Ripening/*metabolism; Cervix Uteri/blood supply/innervation/*metabolism; Denervation; Nitric Oxide Synthase Type III; Nitric Oxide Synthase/biosynthesis; Protein Isoforms/biosynthesis/metabolism; Protein-Serine-Threonine Kinases/biosynthesis; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins/biosynthesis; Vascular Endothelial Growth Factor A/biosynthesis/*metabolism; Vascular Endothelial Growth Factor Receptor-2/biosynthesis; Wistar; Animal/*metabolism
Creator
An entity primarily responsible for making the resource
Mowa C N; Jesmin S; Sakuma I; Usip S; Togashi H; Yoshioka M; Hattori Y; Papka R
Description
An account of the resource
Bilateral neurectomy of the pelvic nerve (BLPN) that carries uterine cervix-related sensory nerves induces dystocia, and administration of its vasoactive neuropeptides induces changes in the cervical microvasculature, resembling those that occur in the ripening cervix. This study was designed to test the hypothesis that (a) the cervix of pregnant rats expresses vascular endothelial growth factor (VEGF) and components of the angiogenic signaling pathway [VEGF receptors (Flt-1, KDR), activity of protein kinase B, Akt (phosphorylated Akt), and endothelial nitric oxide synthase (eNOS)] and von Willebrand Factor (vWF) and that these molecules undergo changes with pregnancy, and (b) bilateral pelvic neurectomy (BLPN) alters levels of VEGF concentration in the cervix. Using RT-PCR and sequencing, two VEGF isoforms, 120 and 164, were identified in the rat cervix. VEGF, VEGF receptor-1 (Flt-1), eNOS, and vWF immunoreactivities (ir) were localized in the microvasculature of cervical stroma. Their protein levels increased during pregnancy but decreased to control levels by 2 days postpartum. VEGF receptor-2 (KDR)-ir was confined to the epithelium of the endocervix. BLPN downregulated levels of VEGF by a third. Therefore, the components of the angiogenic signaling pathway are expressed in the cervix and change over pregnancy. Furthermore, angiogenic and sensory neuronal factors may be important in regulating the dynamic microvasculature in the ripening cervix and may subsequently play a role in cervical ripening and the birth process.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1369/jhc.4A6455.2004" target="_blank" rel="noreferrer noopener">10.1369/jhc.4A6455.2004</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2004
Animal/*metabolism
Animals
Cervical Ripening/*metabolism
Cervix Uteri/blood supply/innervation/*metabolism
Denervation
Department of Anatomy & Neurobiology
Down-Regulation
Enzyme-Linked Immunosorbent Assay
Female
Hattori Y
Immunohistochemistry
Jesmin S
Microcirculation
Mowa C N
NEOMED College of Medicine
Nitric Oxide Synthase Type III
Nitric Oxide Synthase/biosynthesis
Papka R
Phosphorylation
Pregnancy
Protein Isoforms/biosynthesis/metabolism
Protein-Serine-Threonine Kinases/biosynthesis
Proto-Oncogene Proteins c-akt
Proto-Oncogene Proteins/biosynthesis
Rats
Reverse Transcriptase Polymerase Chain Reaction
Sakuma I
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society
Togashi H
Usip S
Vascular Endothelial Growth Factor A/biosynthesis/*metabolism
Vascular Endothelial Growth Factor Receptor-2/biosynthesis
Wistar
Yoshioka M
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1369/jhc.2009.953893" target="_blank" rel="noreferrer noopener">http://doi.org/10.1369/jhc.2009.953893</a>
Pages
923–931
Issue
10
Volume
57
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Advanced osteoarthritis in humans is associated with altered collagen VI expression and upregulation of ER-stress markers Grp78 and bag-1.
Publisher
An entity responsible for making the resource available
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society
Date
A point or period of time associated with an event in the lifecycle of the resource
2009
2009-10
Subject
The topic of the resource
Adult; Humans; Middle Aged; Osteoarthritis; Biomarkers/metabolism; Proteoglycans/biosynthesis; Down-Regulation; Up-Regulation; Cartilage; Antigens/biosynthesis; Bone Neoplasms/metabolism; Chondrosarcoma/metabolism; Collagen Type VI/*biosynthesis; DNA-Binding Proteins/*biosynthesis; Endoplasmic Reticulum/*metabolism; Heat-Shock Proteins/*biosynthesis; Osteosarcoma/metabolism; Transcription Factors/*biosynthesis; Articular/metabolism; Knee/*metabolism/physiopathology
Creator
An entity primarily responsible for making the resource
Nugent Ashleigh E; Speicher Danielle M; Gradisar Ian; McBurney Denise L; Baraga Anthony; Doane Kathleen J; Horton Walter E Jr
Description
An account of the resource
To test the hypothesis that a perturbation of endoplasmic reticulum (ER) function is involved in the pathogenesis of osteoarthritis (OA), articular cartilage was isolated from non-OA patients secondary to resection of osteo- or chondrosarcomas. Intra-joint samples of minimal and advanced osteoarthritic cartilage were isolated from patients undergoing total knee arthroplasty and scored for disease severity. Glucose-regulated protein-78 (grp78) and bcl-2-associated athanogene-1 (bag-1) were detected via immunofluorescence as markers of non-homeostatic ER function. Additionally, the expression of type VI collagen and its integrin receptor, NG2, was determined to examine cartilage matrix health and turnover. There was an upregulation of grp78 in advanced OA, and variable expression in minimal OA. Non-OA cartilage was consistently grp78 negative. The downstream regulator bag-1 was also upregulated in OA compared with normal cartilage. Collagen VI was mainly cell-associated in non-OA cartilage, with a more widespread distribution observed in OA cartilage along with increased intracellular staining intensity. The collagen VI integral membrane proteoglycan receptor NG2 was downregulated in advanced OA compared with its patient-matched minimally involved cartilage sample. These results suggest that chondrocytes exhibit ER stress during OA, in association with upregulation of a large secreted molecule, type VI collagen.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1369/jhc.2009.953893" target="_blank" rel="noreferrer noopener">10.1369/jhc.2009.953893</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2009
Adult
Antigens/biosynthesis
Articular/metabolism
Baraga Anthony
Biomarkers/metabolism
Bone Neoplasms/metabolism
Cartilage
Chondrosarcoma/metabolism
Collagen Type VI/*biosynthesis
Department of Anatomy & Neurobiology
DNA-Binding Proteins/*biosynthesis
Doane Kathleen J
Down-Regulation
Endoplasmic Reticulum/*metabolism
Gradisar Ian
Heat-Shock Proteins/*biosynthesis
Horton Walter E Jr
Humans
Knee/*metabolism/physiopathology
McBurney Denise L
Middle Aged
NEOMED College of Medicine
Nugent Ashleigh E
Osteoarthritis
Osteosarcoma/metabolism
Proteoglycans/biosynthesis
Speicher Danielle M
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society
Transcription Factors/*biosynthesis
Up-Regulation
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1177/002215540405201001" target="_blank" rel="noreferrer noopener">http://doi.org/10.1177/002215540405201001</a>
Pages
1249–1258
Issue
10
Volume
52
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
The role of sensory neurons in cervical ripening: effects of estrogen and neuropeptides.
Publisher
An entity responsible for making the resource available
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society
Date
A point or period of time associated with an event in the lifecycle of the resource
2004
2004-10
Subject
The topic of the resource
Afferent/metabolism/*physiology; Cervical Ripening/*physiology; Cervix Uteri/innervation; Estrogen/physiology; Estrogens/*physiology; Female; Ganglia; Humans; Neurons; Neuropeptides/biosynthesis/*physiology; Pregnancy; Receptors; Spinal/physiology
Creator
An entity primarily responsible for making the resource
Mowa C N; Papka R E
Description
An account of the resource
Central nervous system nuclei and circuits, such as the medial preoptic, ventromedial and paraventricular nuclei of the hypothalamus, play important roles in reproduction and parturition, and are influenced by estrogen. Peripheral autonomic and sensory neurons also play important roles in pregnancy and parturition. Moreover, the steroid hormone estrogen acts directly, not only on the reproductive tract organs (uterus and cervix), but also on the central and peripheral nerves by regulating expression of various neuronal genes. The peripheral primary afferent neurons innervating the uterine cervix relay mechanical and biochemical sensory information induced by local cervical events and by passage of fetuses, to the spinal cord and supraspinal centers. Consequently, the birth process in mammals is influenced by the combined action of neurons and hormones. Peripheral sensory stimuli, induced physiologically by fetal expulsion or mechanically by vaginocervical stimulation, alter behavior, as well as autonomic and neuroendocrine systems. Recent evidence indicates that primary afferent neurons innervating the cervix, in addition to their sensory effects, likely exert local "efferent" actions on the ripening cervix near term. These efferent effects may involve estrogen-regulated production of such neuropeptides as substance P and calcitonin gene-related peptide in lumbosacral dorsal root ganglia, and their release in the cervix. Collectively, these findings suggest an interrelationship among estrogen, cervix-related sensory neurons, and local cervical events near term.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1177/002215540405201001" target="_blank" rel="noreferrer noopener">10.1177/002215540405201001</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2004
Afferent/metabolism/*physiology
Cervical Ripening/*physiology
Cervix Uteri/innervation
Estrogen/physiology
Estrogens/*physiology
Female
Ganglia
Humans
Mowa C N
Neurons
Neuropeptides/biosynthesis/*physiology
Papka R E
Pregnancy
Receptors
Spinal/physiology
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society