1
40
3
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0091-3057(88)90145-1" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0091-3057(88)90145-1</a>
Pages
1089–1092
Issue
4
Volume
30
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
CGS 10746B is able to attenuate the effects of amphetamine: further evidence for dopaminergic mediation.
Publisher
An entity responsible for making the resource available
Pharmacology, biochemistry, and behavior
Date
A point or period of time associated with an event in the lifecycle of the resource
1988
1988-08
Subject
The topic of the resource
Male; Animals; Rats; Dopamine/*physiology; Discrimination (Psychology)/*drug effects; Antipsychotic Agents/*pharmacology; Thiazepines/*pharmacology; Apomorphine/pharmacology; Cocaine/pharmacology; Alkaloids/pharmacology; Dextroamphetamine/antagonists & inhibitors/*pharmacology; Dose-Response Relationship; Drug; Conditioning; Operant/drug effects
Creator
An entity primarily responsible for making the resource
Schechter M D; Boja J W
Description
An account of the resource
Previous results indicate that agents which either decreases synthesis or block postsynaptic dopamine receptors will attenuate the discriminative stimulus produced by d-amphetamine. CGS 10746B has been reported to decrease dopamine release without changing its metabolism or occupying its receptors. In the present study, rats successfully trained to discriminate intraperitoneally administered (0.8 mg/kg) d-amphetamine in a two-lever, food-motivated operant task were observed to be unable to discriminate amphetamine when pretreated with 30 mg/kg CGS 10746B. This antagonism was shown to be dose-responsive and constitutes a third mechanism, i.e., dopamine release inhibition, that evidences the dopaminergic mediation of amphetamine in the discriminative paradigm. When both cathinone (0.8 mg/kg) and cocaine (10.0 mg/kg) were administered to the amphetamine-trained rats they each were recognized as amphetamine and are, thus, considered to generalize to the amphetamine discriminative stimulus. Coadministration of CGS 10746B and cathinone totally antagonized this generalization, whereas pretreatment with CGS 10746B prior to cocaine significantly reduced cocaine's effects. These results implicate dopamine mechanisms in the discriminative stimulus properties of the psychostimulants amphetamine, cathinone and cocaine.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0091-3057(88)90145-1" target="_blank" rel="noreferrer noopener">10.1016/0091-3057(88)90145-1</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1988
Alkaloids/pharmacology
Animals
Antipsychotic Agents/*pharmacology
Apomorphine/pharmacology
Boja J W
Cocaine/pharmacology
Conditioning
Dextroamphetamine/antagonists & inhibitors/*pharmacology
Discrimination (Psychology)/*drug effects
Dopamine/*physiology
Dose-Response Relationship
Drug
Male
Operant/drug effects
Pharmacology, biochemistry, and behavior
Rats
Schechter M D
Thiazepines/*pharmacology
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0091-3057(93)90183-t" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0091-3057(93)90183-t</a>
Pages
661–664
Issue
3
Volume
44
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Cocaine discrimination is attenuated by isradipine and CGS 10746B.
Publisher
An entity responsible for making the resource available
Pharmacology, biochemistry, and behavior
Date
A point or period of time associated with an event in the lifecycle of the resource
1993
1993-03
Subject
The topic of the resource
Animals; Antipsychotic Agents/*pharmacology; Calcium Channel Blockers/*pharmacology; Cocaine/antagonists & inhibitors/*pharmacology; Conditioning; Discrimination (Psychology)/*drug effects; Dose-Response Relationship; Drug; Ibogaine/pharmacology; Isradipine/*pharmacology; Male; Operant/drug effects; Rats; Serotonin Antagonists/pharmacology; Sprague-Dawley; Thiazepines/*pharmacology; Tropanes/pharmacology
Creator
An entity primarily responsible for making the resource
Schechter M D
Description
An account of the resource
The discriminative stimulus properties of cocaine are thought to be mediated by dopaminergic mechanisms that may be modulated by calcium ion influx and/or interact with 5-hydroxytryptamine3 (5-HT3) receptors. To test these possibilities, rats were trained to discriminate between the stimulus properties of 10.0 mg/kg cocaine and its vehicle in a two-lever, food-motivated operant task. Once trained, rats showed a dose-related decrease in discriminative performance when tested with lower cocaine doses. An analysis of the dose-response curve indicated an ED50 value of 3.04 mg/kg. Pretreatment with the presynaptic dopamine release-inhibiting agent CGS 10746B (20-40 mg/kg) resulted in a dose-related decrease in cocaine discrimination with the highest dose significantly attenuating cocaine discrimination. Pretreatment with 10-30 mg/kg isradipine, a calcium channel blocker, also resulted in a dose-related decrease in cocaine discriminative performance. In contrast to these positive results, pretreatment with the 5-HT3 receptor antagonist MDL 72222 (3.5-7.0 mg/kg), or the same doses of ibogaine, did not significantly affect cocaine discrimination. The results suggest that cocaine controls differential responding in a discriminative stimulus task by mechanisms that involve presynaptic release of dopamine, which may be regulated by neuronal calcium influx through L-type calcium channels.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0091-3057(93)90183-t" target="_blank" rel="noreferrer noopener">10.1016/0091-3057(93)90183-t</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1993
Animals
Antipsychotic Agents/*pharmacology
Calcium Channel Blockers/*pharmacology
Cocaine/antagonists & inhibitors/*pharmacology
Conditioning
Discrimination (Psychology)/*drug effects
Dose-Response Relationship
Drug
Ibogaine/pharmacology
Isradipine/*pharmacology
Male
Operant/drug effects
Pharmacology, biochemistry, and behavior
Rats
Schechter M D
Serotonin Antagonists/pharmacology
Sprague-Dawley
Thiazepines/*pharmacology
Tropanes/pharmacology
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0166-4328(95)00167-0" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0166-4328(95)00167-0</a>
Pages
199–205
Issue
1
Volume
74
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Discriminative stimulus properties of CGS 10746B: similarity to dopamine D1 receptor antagonists.
Publisher
An entity responsible for making the resource available
Behavioural brain research
Date
A point or period of time associated with an event in the lifecycle of the resource
1996
1996-01
Subject
The topic of the resource
Amphetamines/pharmacology; Animals; Antipsychotic Agents/*pharmacology; Cholinergic Agents/pharmacology; Clozapine/pharmacology; Cues; Discrimination (Psychology)/*drug effects; Discrimination Learning/drug effects; Dopamine D1/*antagonists & inhibitors; Dose-Response Relationship; Drug; Generalization; Male; Rats; Receptors; Response/drug effects; Serotonin Agents/pharmacology; Serotonin Receptor Agonists/pharmacology; Sprague-Dawley; Thiazepines/*pharmacology
Creator
An entity primarily responsible for making the resource
Meehan S M; Schechter M D
Description
An account of the resource
CGS 10746B is an imidazole-derivative related to the atypical antipsychotic clozapine which produces a decrease in dopamine release without altering dopamine metabolism or occupying D2 receptors. Rats were trained on an appetitively-motivated, two-choice, operant task to discriminate 20.0 mg/kg CGS 10746B from its vehicle. CGS 10746B was highly discriminable, producing rapid acquisition of the discrimination, and its effects were dose-responsive allowing generation of an ED50 value of 6.16 mg/kg. Substitution tests were conducted with other typical and atypical antipsychotic compounds: haloperidol, chlorpromazine, clozapine and SCH 23390. Additional tests examined generalization from the CGS 10746B stimulus properties to the calcium channel blocker isradipine, as well as to the anticholinergics atropine, scopolamine and methylscopolamine, as well as to the serotonergic agonist DOI. Clozapine and SCH 23390 were the only substances to substitute for the CGS 10746B stimulus cue. Results are discussed in terms of potential D1 receptor selectivity of CGS 10746B.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0166-4328(95)00167-0" target="_blank" rel="noreferrer noopener">10.1016/0166-4328(95)00167-0</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1996
Amphetamines/pharmacology
Animals
Antipsychotic Agents/*pharmacology
Behavioural brain research
Cholinergic Agents/pharmacology
Clozapine/pharmacology
Cues
Discrimination (Psychology)/*drug effects
Discrimination Learning/drug effects
Dopamine D1/*antagonists & inhibitors
Dose-Response Relationship
Drug
Generalization
Male
Meehan S M
Rats
Receptors
Response/drug effects
Schechter M D
Serotonin Agents/pharmacology
Serotonin Receptor Agonists/pharmacology
Sprague-Dawley
Thiazepines/*pharmacology