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40
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<a href="http://doi.org/" target="_blank" rel="noreferrer noopener">http://doi.org/</a>
Pages
E274-E275
Issue
12
Volume
127
ISSN
0009-7330
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January 2021 List
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Department of Integrative Medical Sciences
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Dublin Core
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Title
A name given to the resource
Endothelial Trpv4 contributes to pressure overload-induced pathological hypertrophy via modulation of coronary angiogenesis
Publisher
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Circulation Research
Date
A point or period of time associated with an event in the lifecycle of the resource
2020
2020-12-04
Subject
The topic of the resource
Angiogenesis; Fibrosis; Ion channels; Cardiac hypertrophy;
Creator
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Adapala RK; Kanugula AK; Ohanyan VA; Paruchuri SM; Chilian WM; Thodeti CK
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<a href="http://doi.org/" target="_blank" rel="noreferrer noopener"></a>
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journalArticle
2020
Adapala RK
angiogenesis
Cardiac hypertrophy
Chilian WM
Circulation research
Department of Integrative Medical Sciences
Fibrosis
Ion Channels
January 2021 List
journalArticle
Kanugula AK
NEOMED College of Graduate Studies
NEOMED College of Medicine
NEOMED Student Publications
Ohanyan VA
Paruchuri SM
Thodeti CK
-
Text
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<a href="http://doi.org/10.1038/s41598-020-66617-2" target="_blank" rel="noreferrer noopener">http://doi.org/10.1038/s41598-020-66617-2</a>
Pages
9827
Issue
1
Volume
10
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July 2020 List
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Title
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Transient receptor potential vanilloid channel regulates fibroblast differentiation and airway remodeling by modulating redox signals through NADPH oxidase 4.
Publisher
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Scientific Reports
Date
A point or period of time associated with an event in the lifecycle of the resource
2020
2020-06
Subject
The topic of the resource
ASTHMA; CAPSAICIN receptors; GROWTH factors; NICOTINAMIDE adenine dinucleotide phosphate; OXIDATION-reduction reaction; TRP channels
Creator
An entity primarily responsible for making the resource
Al-Azzam N; Teegala LR; Pokhrel S; Ghebreigziabher S; Chachkovskyy T; Thodeti S; Gavilanes I; Covington K; Thodeti CK; Paruchuri S
Description
An account of the resource
Asthma is characterized by pathological airway remodeling resulting from persistent myofibroblast activation. Although transforming growth factor beta 1 (TGFβ1), mechanical signals, and reactive oxygen species (ROS) are implicated in fibroblast differentiation, their integration is still elusive. We identified that Transient Receptor Potential Vanilloid 4 (TRPV4), a mechanosensitive ion channel mediates lung fibroblast (LF) differentiation and D. farinae-induced airway remodeling via a novel
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1038/s41598-020-66617-2" target="_blank" rel="noreferrer noopener">10.1038/s41598-020-66617-2</a>
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journalArticle
2020
Al-Azzam N
asthma
CAPSAICIN receptors
Chachkovskyy T
Covington K
Department of Integrative Medical Sciences
Gavilanes I
Ghebreigziabher S
growth factors
journalArticle
July 2020 List
NEOMED College of Medicine
NEOMED College of Medicine Student
NEOMED Student Publications
NICOTINAMIDE adenine dinucleotide phosphate
OXIDATION-reduction reaction
Paruchuri S
Pokhrel S
Scientific reports
Teegala LR
Thodeti CK
Thodeti S
TRP channels
-
Text
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<a href="http://doi.org/10.1002/jcp.30116" target="_blank" rel="noreferrer noopener">http://doi.org/10.1002/jcp.30116</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
ISSN
1097-4652 0021-9541
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Title
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Transient receptor potential vanilloid 4 channel deletion regulates pathological but not developmental retinal angiogenesis.
Publisher
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Journal of Cellular Physiology
Date
A point or period of time associated with an event in the lifecycle of the resource
2020
2020-10-20
Subject
The topic of the resource
neovascularization; TRPV4; mechanotransduction; ECM stiffness; human retinal endothelial cells
Creator
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Cappelli HC;Guarino BD;Kanugula AK;Adapala R K;Perera V;Smith MA;Paruchuri S;Thodeti CK
Description
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Transient receptor potential vanilloid 4 (TRPV4) channels are mechanosensitive ion channels that regulate systemic endothelial cell (EC) functions such as vasodilation, permeability, and angiogenesis. TRPV4 is expressed in retinal ganglion cells, Müller glia, pigment epithelium, microvascular ECs, and modulates cell volume regulation, calcium homeostasis, and survival. TRPV4-mediated physiological or pathological retinal angiogenesis remains poorly understood. Here, we demonstrate that TRPV4 is expressed, functional, and mechanosensitive in retinal ECs. The genetic deletion of TRPV4 did not affect postnatal developmental angiogenesis but increased pathological neovascularization in response to oxygen-induced retinopathy (OIR). Retinal vessels from TRPV4 knockout mice subjected to OIR exhibited neovascular tufts that projected into the vitreous humor and displayed reduced pericyte coverage compared with wild-type mice. These results suggest that TRPV4 is a regulator of retinal angiogenesis, its deletion augments pathological retinal angiogenesis, and that TRPV4 could be a novel target for the development of therapies against neovascular ocular diseases.
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<a href="http://doi.org/10.1002/jcp.30116" target="_blank" rel="noreferrer noopener">10.1002/jcp.30116</a>
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journalArticle
2020
Adapala R K
Cappelli HC
Department of Integrative Medical Sciences
Department of Pharmaceutical Sciences
ECM stiffness
Guarino BD
human retinal endothelial cells
Journal of cellular physiology
journalArticle
Kanugula AK
Mechanotransduction
NEOMED College of Medicine
NEOMED College of Medicine Postdoc
NEOMED College of Medicine Student
NEOMED College of Pharmacy
NEOMED Postdoc Publications
NEOMED Student Publications
Neovascularization
October 2020 List
Paruchuri S
Perera V
Smith MA
Thodeti CK
TRPV4
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Text
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<a href="http://doi.org/10.1096/fasebj.2020.34.s1.05946" target="_blank" rel="noreferrer noopener">http://doi.org/10.1096/fasebj.2020.34.s1.05946</a>
Issue
1
Volume
34
ISSN
0892-6638
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Department of Integrative Medical Sciences
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Title
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Extracellular vesicles from tumor microenvironment transforms endothelial cell phenotype via downregulation of TRPV4 channels
Publisher
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Faseb Journal
Date
A point or period of time associated with an event in the lifecycle of the resource
2020
2020-04
Creator
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Guarino B;Adapala R;Kanugula A;Dougherty J;Paruchuri S;Mahmood K;Thodeti CK
Description
An account of the resource
Angiogenesis, the formation of new blood vessels from existing ones, is a normal physiological process. However, deregulation of angiogenesis can lead to pathological states such as cancer, that is characterized by hyper‐permeable and tortuous vessels. We have recently shown a significant decrease in functional expression of the mechanosensitive ion channel, transient potential receptor vanilloid 4 (TRPV4), in tumor endothelial cells (TEC). Further, pharmacological activation of TRPV4 induced normalization of tumor vasculature and improved cancer therapy. However, the molecular mechanisms by which TRPV4 is downregulated in TEC is not yet known. To determine this mechanism, we focused on extracellular vesicles (EVs) derived from tumor cells. We first collected conditioned media (TCM) from tumor cells with and without pre‐treatment of an exosome inhibitor, GW4869. We found that treatment of human normal endothelial cells (hNEC) with TCM transformed them into tumor‐endothelial like (hTEC) phenotype as revealed by expression of TEM8, VEGFR2 membrane translocation, and abnormal tube formation. However, TCM from exosome inhibitor‐treated cells, failed to induce endothelial transformation. Further, we found that EVs isolated from TCM induced hNEC transformation to hTEC. Mechanistically, we found that tumor derived EVs induced functional downregulation of TRPV4 in hNEC as assessed by calcium imaging. Taken together, our results suggest that tumor derived EVs transforms normal endothelial cells via downregulation of TRPV4 channels.
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<a href="http://doi.org/10.1096/fasebj.2020.34.s1.05946" target="_blank" rel="noreferrer noopener">10.1096/fasebj.2020.34.s1.05946</a>
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journalArticle
2020
Adapala R
Department of Integrative Medical Sciences
Dougherty J
Faseb Journal
Guarino B
journalArticle
Kanugula A
Mahmood K
NEOMED College of Medicine Postdoc
NEOMED College of Medicine Student
NEOMED Postdoc Publications
NEOMED Student Publications
Paruchuri S
September 2020 List
Thodeti CK
-
Text
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<a href="http://doi.org/10.1016/j.exer.2020.108257" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.exer.2020.108257</a>
Pages
108257
Volume
201
ISSN
1096-0007
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September 2020 List
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NEOMED College of Medicine
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Department of Integrative Medical Sciences
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Title
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The role of TRPV4 channels in ocular function and pathologies.
Publisher
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Experimental Eye Research
Date
A point or period of time associated with an event in the lifecycle of the resource
2020
2020-09-29
Subject
The topic of the resource
Glaucoma; TRPV4; Angiogenesis; Retina; Calcium channel; Cornea; Diabetic retinopathy; Lens; Osmolarity
Creator
An entity primarily responsible for making the resource
Guarino BD;Paruchuri S;Thodeti CK
Description
An account of the resource
Transient potential receptor vanilloid 4 (TRPV4) is an ion channel responsible for sensing osmotic and mechanical signals, which in turn regulates calcium signaling across cell membranes. TRPV4 is widely expressed throughout the body, and plays an important role in normal physiological function, as well as different pathologies, however, its role in the eye is not well known. In the eye, TRPV4 is expressed in various tissues, such as the retina, corneal epithelium, ciliary body, and the lens. In this review, we provide an overview on TRPV4 structure, activation, mutations, and summarize the current knowledge of TRPV4 function and signaling mechanisms in various locations throughout the eye, as well as its role in ocular diseases, such as glaucoma and diabetic retinopathy. Based on the available data, we highlight the therapeutic potential of TRPV4 as well as the shortcomings of current research. Finally, we provide future perspectives on the implications of targeting TRPV4 to treat various ocular pathologies. (Copyright © 2020 Elsevier Ltd. All rights reserved.)
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<a href="http://doi.org/10.1016/j.exer.2020.108257" target="_blank" rel="noreferrer noopener">10.1016/j.exer.2020.108257</a>
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journalArticle
2020
angiogenesis
calcium channel
Cornea
Department of Integrative Medical Sciences
diabetic retinopathy
Experimental eye research
Glaucoma
Guarino BD
journalArticle
Lens
NEOMED College of Medicine
NEOMED College of Medicine Student
NEOMED Student Publications
Osmolarity
Paruchuri S
retina
September 2020 List
Thodeti CK
TRPV4
-
Text
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URL Address
<a href="http://doi.org/10.1007/s10456-021-09775-9" target="_blank" rel="noreferrer noopener">http://doi.org/10.1007/s10456-021-09775-9</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
ISSN
1573-7209 0969-6970
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Update Year & Number
March 2021 List
NEOMED College
NEOMED College of Medicine
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Department of Integrative Medical Sciences
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Title
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Endothelial TRPV4 channels prevent tumor growth and metastasis via modulation of tumor angiogenesis and vascular integrity.
Publisher
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Angiogenesis
Date
A point or period of time associated with an event in the lifecycle of the resource
2021
2021-03-03
Subject
The topic of the resource
Endothelial cell; Metastasis; Transient receptor potential vanilloid 4; Tumor angiogenesis; Vascular endothelial growth factor receptor 2
Creator
An entity primarily responsible for making the resource
Kanugula AK; Adapala RK; Jamaiyar A; Lenkey N; Guarino BD; Liedtke W; Yin L; Paruchuri S; Thodeti CK
Description
An account of the resource
Transient receptor potential vanilloid 4 (TRPV4) is a ubiquitously expressed polymodally activated ion channel. TRPV4 has been implicated in tumor progression; however, the cell-specific role of TRPV4 in tumor growth, angiogenesis, and metastasis is unknown. Here, we generated endothelial-specific TRPV4 knockout (TRPV4(ECKO)) mice by crossing TRPV4(lox/lox) mice with Tie2-Cre mice. Tumor growth and metastasis were significantly increased in a syngeneic Lewis lung carcinoma tumor model of TRPV4(ECKO) mice compared to TRPV4(l)(ox/lox) mice. Multiphoton microscopy, dextran leakage, and immunohistochemical analysis revealed increased tumor angiogenesis and metastasis that were correlated with aberrant leaky vessels (increased width and reduced pericyte and VE-cadherin coverage). Mechanistically, increases in VEGFR2, p-ERK, and MMP-9 expression and DQ gelatinase activity were observed in the TRPV4(ECKO) mouse tumors. Our results demonstrated that endothelial TRPV4 is a critical modulator of vascular integrity and tumor angiogenesis and that deletion of TRPV4 promotes tumor angiogenesis, growth, and metastasis.
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<a href="http://doi.org/10.1007/s10456-021-09775-9" target="_blank" rel="noreferrer noopener">10.1007/s10456-021-09775-9</a>
Format
The file format, physical medium, or dimensions of the resource
journalArticle
2021
Adapala RK
angiogenesis
Department of Integrative Medical Sciences
endothelial cell
Guarino BD
Jamaiyar A
journalArticle
Kanugula AK
Lenkey N
Liedtke W
March 2021 List
Metastasis
NEOMED College of Medicine
NEOMED Postdoc Publications
NEOMED Student Publications
Paruchuri S
Thodeti CK
Transient receptor potential vanilloid 4
tumor angiogenesis
Vascular endothelial growth factor receptor 2
Yin L