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40
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Text
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Pages
34–39
Issue
1
Volume
277
Dublin Core
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Title
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Testosterone causes direct relaxation of rat thoracic aorta.
Publisher
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The Journal of pharmacology and experimental therapeutics
Date
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1996
1996-04
Subject
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Female; Male; Animals; Rats; In Vitro Techniques; Vasodilation/*drug effects; Testosterone/*pharmacology; Phenylephrine/pharmacology; Calcium Channels/drug effects; Dose-Response Relationship; Drug; Sprague-Dawley; Aorta; Endothelium; Thoracic/*drug effects/physiology; Vascular/physiology
Creator
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Costarella C E; Stallone J N; Rutecki G W; Whittier F C
Description
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Several recent studies have provided evidence that gonadal steroid hormones can exert acute (nongenomic) effects on both neural and vascular tissues. This study examines the acute effects of testosterone (T) on vascular reactivity of the rat thoracic aorta. Aortic rings from male Sprague-Dawley (SD) rats with (+ENDO) and without (-ENDO) endothelium were prepared for isometric tension recording. In (+ENDO) male aortae precontracted with phenylephrine (PE), T produced dose-dependent relaxation from 25 microM (30.3 +/- 7.1%) to 300 microM (99.4 +/- 0.4%), whereas T vehicle (\textless or = 0.5% ethanol) had no effect. Pretreatment of (+ENDO) aortae with T (50 microM; 10 min) attenuated subsequent contractile responses to PE. Both maximal contraction and sensitivity to PE were reduced by T. Pretreatment of (+ENDO) aortae with both T and N omega-nitro-L-arginine methyl ester (250 microM) reversed in part the attenuating effects of T alone; however, both maximal response and sensitivity to PE were still reduced compared to control rings (without T or N omega-nitro-L-arginine methyl ester). Pretreatment of (-ENDO) aortae with T reduced sensitivity to PE, but had no effect on maximal contraction. T pretreatment (50 microM; 10 min) of both (+ENDO) female SD aortae and (+ENDO) male testicular-feminized rat aortae reduced maximal contraction and sensitivity to PE in both groups to a similar extent as in (+ENDO) male SD aortae. These data suggest that T has a direct vasodilating effect on the rat aorta, which involves endothelium-dependent (enhanced NO release) and -independent mechanisms and is gender- and intracellular androgen receptor-independent.
Rights
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1996
Animals
Aorta
Calcium Channels/drug effects
Costarella C E
Department of Internal Medicine
Dose-Response Relationship
Drug
Endothelium
Female
In Vitro Techniques
Male
NEOMED College of Medicine
Phenylephrine/pharmacology
Rats
Rutecki G W
Sprague-Dawley
Stallone J N
Testosterone/*pharmacology
The Journal of pharmacology and experimental therapeutics
Thoracic/*drug effects/physiology
Vascular/physiology
Vasodilation/*drug effects
Whittier F C