Browse Items · NEOMED Bibliography Database

PKCalpha mediates acetylcholine-induced activation of TRPV4-dependent calcium influx in endothelial cells.

Transient receptor potential vanilloid channel 4 (TRPV4) is a polymodally activated nonselective cationic channel implicated in the regulation of vasodilation and hypertension. We and others have recently shown that cyclic stretch and shear stress…

Tags: 2011, Acetylcholine/*pharmacology, Adapala Ravi K, American journal of physiology. Heart and circulatory physiology, Animals, Bratz Ian N, Calcium Signaling/*drug effects, Carbazoles/pharmacology, Cells, Cultured, Department of Integrative Medical Sciences, Endothelial Cells/*drug effects/enzymology, Enzyme Activation, Inbred C57BL, Knockout, Male, Mesenteric Arteries/drug effects/enzymology, Meszaros J Gary, Mice, Mutation, NEOMED College of Medicine, Nitric Oxide Synthase Type III/metabolism, Phosphorylation, Protein Kinase C-alpha/genetics/*metabolism, Protein Kinase Inhibitors/pharmacology, Suzuki Makoto, Talasila Phani K, Tetradecanoylphorbol Acetate/pharmacology, Thodeti Charles K, Time Factors, Transfection, TRPV Cation Channels/*agonists/deficiency/genetics/metabolism, Vasodilation/*drug effects, Vasodilator Agents/*pharmacology, Zhang David X

The role of NMDA receptors in long-term potentiation (LTP) and depression (LTD) in rat visual cortex.

The purpose of the present study was to improve our understanding of the role of NMDA receptors in neocortical synaptic plasticity. In slices of rat visual cortex the field potential elicited in layer III in response to white matter stimulation…

Osteoactivin Promotes Migration of Oral Squamous Cell Carcinomas.

Nearly 50% of patients with oral squamous cell carcinoma (OSCC) die of metastases or locoregional recurrence. Metastasis is mediated by cancer cell adhesion, migration, and invasion. Osteoactivin (OA) overexpression plays a role in metastases in…

Effectiveness of a group exercise program in a long-term care facility: a randomized pilot trial.

OBJECTIVE: The purpose of this pilot was to determine whether a strength and flexibility program in frail long-term care facility (LTC) residents would result in improved function. DESIGN: A prospective, randomized, controlled, semicrossover trial…

Alternative microglial activation is associated with cessation of progressive dopamine neuron loss in mice systemically administered lipopolysaccharide.

Inflammation arising from central and/or peripheral sources contributes to the pathogenesis of multiple neurodegenerative diseases including Parkinson's disease (PD). Emerging data suggest that differential activation of glia could lead to the…

Outcomes of non-STEMI patients transported by emergency medical services vs private vehicle.

BACKGROUND: Non-ST-segment elevation myocardial infarctions (NSTEMIs) are more common but less studied than ST-segment elevation myocardial infarctions (STEMIs) treated by emergency medical services (EMS). OBJECTIVE: The purpose of this study was to…

Tags: *Electrocardiography, 2016, 80 and over, Adult, Age Distribution, Aged, Baughman Kristin, Bhalla Mary Colleen, Comparative Studies, Demography, Department of Family & Community Medicine, Dials Sarah, Electrocardiography, Emergency Medical Services – Methods, Emergency Medical Services – Statistics and Numerical Data, Emergency Medical Services/methods/*statistics & numerical data, Evaluation Research, Female, Frey Jennifer, Hospital Mortality, Human, Humans, Length of Stay – Statistics and Numerical Data, Length of Stay/statistics & numerical data, Male, Medical Records – Statistics and Numerical Data, Medical Records/statistics & numerical data, Middle Age, Middle Aged, Multicenter Studies, Myocardial Infarction – Diagnosis, Myocardial Infarction – Mortality, Myocardial Infarction – Therapy, Myocardial Infarction/diagnosis/*mortality/therapy, NEOMED College of Medicine, Ohio, Ohio/epidemiology, Outcome Assessment – Statistics and Numerical Data, Outcome Assessment (Health Care)/*statistics & numerical data, Retrospective Design, Retrospective Studies, Severity of Illness Index, Severity of Illness Indices, The American journal of emergency medicine, Time Factors, Transportation of Patients – Methods, Transportation of Patients – Statistics and Numerical Data, Transportation of Patients/*methods/*statistics & numerical data, Trauma Centers – Statistics and Numerical Data, Trauma Centers/statistics & numerical data, Validation Studies

Understanding residents' work: moving beyond counting hours to assessing educational value.

PURPOSE: To begin to understand how residents' work affects their own educations and the hospitals in which most of their training takes place, the authors undertook a systematic review of the literature analyzing residents' activities. This review…

Tags: *Workload, 2003, Academic medicine : journal of the Association of American Medical Colleges, Boex James R, Department of Family & Community Medicine, Education, Graduate/*statistics & numerical data, Humans, Internship and Residency/*statistics & numerical data, Leahy Peter J, Medical, Medicine/statistics & numerical data, NEOMED College of Medicine, Specialization, Time Factors

Behavioral effects of N-ethyl-3,4-methylenedioxyamphetamine (MDE; "EVE").

Eight male rats were trained to discriminate 2.0 mg/kg

Tags: 1987, 3, 4-methylenedioxyamphetamine, 4-Methylenedioxyamphetamine/analogs & derivatives/*pharmacology, Amphetamines/*pharmacology, Animals, Boja J W, Discrimination (Psychology), Dose-Response Relationship, Drug, Inbred Strains, Legislation, Male, N-Methyl-3, Pharmacology, biochemistry, and behavior, Rats, Schechter M D, Time Factors, United States

Norfenfluramine, the fenfluramine metabolite, provides stimulus control: evidence for serotonergic mediation.

Nine male rats were trained to discriminate 1.4 mg/kg norfenfluramine (NF) from its vehicle using a two-lever, food-motivated, operant discrimination task. Once trained, the rats showed a dose-dependent decrease in responding on the

Tags: 1988, Animal/*drug effects, Animals, Behavior, Boja J W, Discrimination (Psychology)/*drug effects, Dose-Response Relationship, Drug, Fenfluramine/*analogs & derivatives/*pharmacology, Inbred Strains, Male, Norfenfluramine/*pharmacology, Pharmacology, biochemistry, and behavior, Rats, Receptors, Schechter M D, Serotonin/pharmacology, Serotonin/physiology, Time Factors

Myocardial work load is a major determinant of norepinephrine-induced left ventricular dysfunction.

This study was conducted to determine whether increased myocardial energy demand plays a role in norepinephrine (NE)-induced left ventricular (LV) dysfunction. A range of arterial pressure-heart rate (P-R) products (myocardial energy demand) was…

Mechanical Thrombectomy for Patients with In-Hospital Ischemic Stroke: A Case-Control Study.

BACKGROUND AND AIM: Patients with in-hospital acute ischemic stroke (AIS) have, in general, worse outcomes compared to those presenting from the community, partly attributed to the numerous contraindications to intravenous thrombolysis. We aimed …

Ablation of the hypothalamic arcuate-median eminence region reduces the concentration of vasoactive intestinal peptide in the anterior pituitary gland of male rats.

This study was designed to determine the influence of the hypothalamus on the content of vasoactive intestinal peptide (VIP) in the anterior pituitary. Disruption of the hypothalamic-pituitary connection was performed by ablating the arcuate-median…

Simulation of breast cancer screening: quality assessment of two protocols.

Healthcare professionals must make breast cancer screening decisions without the help of clear answers in current medical knowledge. This study used computer simulation to evaluate two screening protocols. The American Cancer Society (ACS) protocol…

Inhibition of long-term potentiation development in rat hippocampal slice by alpha 2-macroglobulin, an acute-phase protein in the brain.

Alpha-2-macroglobulin (alpha 2M) in the rat and human brain is an acute-phase protein synthesized primarily by astrocytes, and it has been implicated in Alzheimer's disease and other neuropathological processes. The activated forms of alpha 2M, but…

Tags: 1996, alpha-Macroglobulins/*pharmacology, Animals, Cavus I, Electric Stimulation, Hippocampus/drug effects/*physiology, Humans, In Vitro Techniques, Journal of neuroscience research, Koo P H, Long-Term Potentiation/*drug effects, Methylamines/pharmacology, Neurites/drug effects/*physiology, Pyramidal Cells/drug effects/physiology, Rats, Synapses/drug effects/physiology, Synaptic Transmission/drug effects, Teyler T J, Time Factors

Effect of epinephrine on alveolar liquid clearance in the rat.

Endogenous epinephrine has been found to increase alveolar liquid clearance (ALC) in several pulmonary edema models. In this study, we infused epinephrine intravenously for 1 h in anesthetized rats to produce plasma epinephrine concentrations…

Acute exercise attenuates cardiac autonomic regulation in hypertensive rats.

Dynamic exercise may be used as a safe, therapeutic approach to reduce sympathetic nerve activity at rest and thus may be beneficial for individuals with hypertension. Therefore, we tested the hypothesis that a single bout of mild to moderate dynamic…

Long-term results of percutaneous lumbar decompression for LSS: two-year outcomes.

OBJECTIVE: The aim of this report was to evaluate the long-term effectiveness and safety of mild lumbar decompression for the treatment of neurogenic claudication associated with lumbar spinal stenosis. This technique uses a percutaneous dorsal…

Impact of reirradiation of painful osseous metastases on quality of life and function: a secondary analysis of the NCIC CTG SC.20 randomized trial.

PURPOSE: We previously demonstrated that 48% of patients with pain at sites of previously irradiated bone metastases benefit from reirradiation. It is unknown whether alleviating pain also improves patient perception of quality of life (QOL).…

Single versus multiple fractions of repeat radiation for painful bone metastases: a randomised, controlled, non-inferiority trial.

BACKGROUND: Although repeat radiation treatment has been shown to palliate pain in patients with bone metastases from multiple primary origin sites, data for the best possible dose fractionation schedules are lacking. We aimed to assess two dose…

Tags: *Dose Fractionation, *Radiotherapy, 2014, Aged, Analgesics – Therapeutic Use, Analgesics/therapeutic use, Australia, Babington Scott, Bone Neoplasms, Bone Neoplasms – Complications, Bone Neoplasms – Radiotherapy, Bone Neoplasms/complications/*radiotherapy/*secondary, Brief pain inventory, Brundage Michael D, Canada, Cauda Equina, Chen Bingshu E, Chi Square Test, Chi-Square Distribution, Chow Edward, Clinical Assessment Tools, Clinical Trials, Computer-Assisted, Computer-Assisted – Adverse Effects, Computer-Assisted/adverse effects, Demas William F, Europe, Female, Fractures, Funding Source, Hartsell William F, Hoskin Peter, Human, Humans, Intention to Treat Analysis, Israel, Logistic Models, Logistic Regression, Male, Meyer Ralph M, Middle Age, Middle Aged, Nabid Abdenour, New Zealand, Odds Ratio, Oei Bing, Pain – Diagnosis, Pain – Drug Therapy, Pain – Etiology, Pain – Radiotherapy, Pain Measurement, Pain/diagnosis/drug therapy/*etiology/*radiotherapy, Questionnaires, Radiation, Radiation Dosage, Radiotherapy, Radiotherapy Planning, Risk Factors, Roos Daniel, Scales, Spinal Cord Compression – Etiology, Spinal Cord Compression/etiology, Spontaneous – Etiology, Spontaneous/etiology, Surveys and Questionnaires, The Lancet. Oncology, Time Factors, Tissing-Tan Caroline J A, Treatment Outcome, Treatment Outcomes, van der Linden Yvette M, Wilson Carolyn F, Wong Rebecca K S, Wu Jackson S Y

Temperature-sensitive Medications in Interfacility Transport: The Ice Pack Myth.

INTRODUCTION: Critical Care Transport teams use various strategies to maintain temperature sensitive drugs and equipment at optimal temperature. The purpose of this study was to examine the effectiveness of current passive refrigeration of…

Lifestyle factors and primary care specialty selection: comparing 2012-2013 graduating and matriculating medical students' thoughts on specialty lifestyle.

PURPOSE: To compare how first-year (MS1) and fourth-year students (MS4) ascribe importance to lifestyle domains and specialty characteristics in specialty selection, and compare students' ratings with their primary care (PC) interest. METHOD: In…

Early astrocyte redistribution in the optic nerve precedes axonopathy in the DBA/2J mouse model of glaucoma.

Glaucoma challenges the survival of retinal ganglion cell axons in the optic nerve through processes dependent on both aging and ocular pressure. Relevant stressors likely include complex interplay between axons and astrocytes, both in the retina and…

Final Two-Year Outcomes for the Sentry Bioconvertible Inferior Vena Cava Filter in Patients Requiring Temporary Protection from Pulmonary Embolism.

PURPOSE: To report final 2-year outcomes with the Sentry bioconvertible inferior vena cava (IVC) filter in patients requiring temporary protection against pulmonary embolism (PE). MATERIALS AND METHODS: In a prospective multicenter trial, the…

Neuroprotective role of estrogen upon methamphetamine and related neurotoxins within the nigrostriatal dopaminergic system.

In this report we describe some of the data on the capacity for estrogen to function as a neuroprotectant of the nigrostriatal dopaminergic (NSDA) system. The data show that estrogen (E) can alter two different response characteristics to NSDA…

Tags: 2000, Animals, Annals of the New York Academy of Sciences, Corpus Striatum/*drug effects/metabolism, Dluzen D E, Dopamine/*metabolism, Drug Interactions, Estrogens/*administration & dosage, McDermott J L, Methamphetamine/antagonists & inhibitors/*toxicity, Neurotoxins/antagonists & inhibitors/*toxicity, Substantia Nigra/*drug effects/metabolism, Time Factors

Relationships among gender, age, time, and temperature in methamphetamine-induced striatal dopaminergic neurotoxicity.

A neurotoxic regimen of methamphetamine (MA-40 mg/kg ip) administered at 0 (control-MA vehicle), 0.5 and 72 h prior to determinations of striatal dopamine (DA) and DOPAC (3,4-dihydroxyphenylacetic acid)/DA ratios were compared among juvenile and…

Olfactory bulb norepinephrine depletion abolishes vasopressin and oxytocin preservation of social recognition responses in rats.

Male rats were implanted bilaterally with cannulae directed at the olfactory bulbs and infused with either vehicle or 6-OHDA to selectively deplete norepinephrine concentrations at this site. At 5-7 days following this treatment, these animals…

Tags: *Social Behavior, 1998, Animals, Arginine Vasopressin/administration & dosage/*pharmacology, Dluzen D E, Infusions, Landgraf R, Male, Muraoka S, Neuroscience letters, Norepinephrine/*physiology, Olfactory Bulb/drug effects/*physiology, Oxidopamine/administration & dosage/pharmacology, Oxytocin/administration & dosage/*pharmacology, Parenteral, Rats, Time Factors, Wistar

The effect of freezing and extraction upon striatal dopaminergic function.

Determinations of striatal dopamine (DA) and 3,4-dihydroxyphenylacetic acid (DOPAC) concentrations were compared under conditions where tissue was either frozen followed by extraction (FE) or extracted followed by freezing (EF). In Experiment 1,…

Tags: *Freezing, 2011, 3, 4-Dihydroxyphenylacetic Acid/metabolism, Analysis of Variance, Animals, Chemical Fractionation/methods, Corpus Striatum/*metabolism, Cryopreservation/methods, Dluzen Dean E, Dopamine/*metabolism, Journal of neuroscience methods, Male, Mice, Time Factors

Spatial and temporal variations in extracellular matrix of periocular and corneal regions during corneal stromal development.

The development of the avian corneal stroma occurs in discrete developmental stages. During this sequence of events, the neural crest-derived corneal fibroblast precursor cells are surrounded by distinct extracellular matrices which change both…

Tags: *Extracellular Matrix, 1996, Animals, Birk D E, Cell Differentiation, Chick Embryo, Collagen/biosynthesis, Cornea/chemistry/*embryology/metabolism, Doane K J, Experimental eye research, Eye Proteins/analysis, Fibroblasts/cytology, Glycoproteins/analysis, McLaughlin J S, Neural Crest/cytology, Proteoglycans/biosynthesis, Time Factors, Ting W H

Characterization of the early events in vitamin C and K3-induced death of human bladder tumor cells.

Timing and type of surgical treatment of Clostridium difficile-associated disease: a practice management guideline from the Eastern Association for the Surgery of Trauma.

BACKGROUND: Clostridium difficile infection is the leading cause of nosocomial diarrhea in the United States; however, few patients will develop fulminant C. difficile-associated disease (CDAD), necessitating an urgent operative intervention.…

Tags: *Clostridium difficile, *Practice Guidelines as Topic, *Societies, *Traumatology, 2014, Bosarge Patrick, Clostridium difficile, Clostridium Infections – Epidemiology, Clostridium Infections – Microbiology, Clostridium Infections – Surgery, Clostridium Infections/epidemiology/microbiology/*surgery, Cross Infection – Epidemiology, Cross Infection – Microbiology, Cross Infection – Surgery, Cross Infection/epidemiology/microbiology/*surgery, Dorion Heath, Duane Therese M, Enniss Toby, Ferrada Paula, Haut Elliott R, Human, Humans, Incidence, Johnson Emily, Martin Niels D, Medical, Medical Organizations, Meta Analysis, Operative Time, Praba-Egge Anita, Practice Guidelines, Rushing Amy, Sultan Shahnaz, Survival – Trends, Survival Rate/trends, systematic review, The journal of trauma and acute care surgery, Time Factors, Traumatology, United States, United States/epidemiology, Velopulos Catherine G

A new dosing paradigm: high-dose, short-course fluoroquinolone therapy for community-acquired pneumonia.

The goals of optimal antimicrobial therapy are to treat infection effectively, to improve the clinical condition of the patient, and to prevent the emergence of resistant bacterial strains. For ideal drug usage the World Health Organization…

Tags: 2003, Clinical cornerstone, Community-Acquired Infections/*drug therapy, Department of Internal Medicine, File Thomas M Jr, Fluoroquinolones/*administration & dosage/pharmacology/therapeutic use, Humans, NEOMED College of Medicine, Ofloxacin/administration & dosage/pharmacology/therapeutic use, Pneumococcal/*drug therapy, Pneumonia, Safety, Time Factors, Treatment Outcome

Recommendations for treatment of hospital-acquired and ventilator-associated pneumonia: review of recent international guidelines.

Recently published guidelines for the management of hospital-acquired pneumonia and ventilator-associated pneumonia are reviewed for recommendations regarding diagnosis and antimicrobial therapy to assess the implications for development of future…

Tags: *Practice Guidelines as Topic, 2010, Anti-Bacterial Agents/*therapeutic use, Bacteria/drug effects/isolation & purification, Bacterial/diagnosis/*drug therapy, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, Clinical Trials as Topic, Cross Infection/diagnosis/*drug therapy, Department of Internal Medicine, File Thomas M Jr, Hospitals, Humans, Microbial Sensitivity Tests, NEOMED College of Medicine, Pneumonia, Time Factors, Ventilator-Associated/diagnosis/*drug therapy

Macrolide therapy for community-acquired pneumonia due to atypical pathogens: outcome assessment at an early time point.

BACKGROUND: Therapy directed against atypical pathogens in patients with community-acquired pneumonia (CAP) is often recommended. This post-hoc analysis evaluated the effect of addition of a macrolide to ceftaroline fosamil or ceftriaxone treatment…

Tags: 2017, 80 and over, Adult, Aged, Anti-Bacterial Agents/adverse effects/*therapeutic use, Atypical pathogen, Bacterial/*drug therapy, Ceftaroline fosamil, Ceftriaxone/adverse effects/*therapeutic use, Cephalosporins/adverse effects/*therapeutic use, Chlamydial Pneumonia, Chlamydophila pneumoniae, Clinical Trials, Combination/adverse effects/methods, Community-Acquired Infections/*drug therapy, Community-acquired pneumonia, Department of Internal Medicine, Double-Blind Method, Drug Therapy, Eckburg Paul B, Female, File Thomas M Jr, Friedland H David, Humans, International journal of antimicrobial agents, Legionella pneumophila, Llorens Lily, Macrolide, Macrolides/adverse effects/*therapeutic use, Male, Middle Aged, Mycoplasma, Mycoplasma pneumoniae, NEOMED College of Medicine, Phase III as Topic, Pneumonia, Randomized Controlled Trials as Topic, Talbot George H, Time Factors, Treatment Outcome

What can we learn from the time course of untreated and partially treated community-onset Streptococcus pneumoniae pneumonia? A clinical perspective on superiority and noninferiority trial designs for mild community-acquired pneumonia.

There are no well-designed placebo-controlled clinical trials in the recent era that precisely define the magnitude of the drug effect of antimicrobial therapy for mild community-acquired pneumonia (CAP). However, there is evidence that ineffective…

Tags: *Research Design, 2008, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, Community-Acquired Infections/*drug therapy/microbiology, Department of Internal Medicine, Disease Progression, File Thomas M Jr, Humans, NEOMED College of Medicine, Pneumococcal/*drug therapy/microbiology, Pneumonia, Randomized Controlled Trials as Topic/*methods, Schentag Jerome J, Streptococcus pneumoniae/*isolation & purification, Time Factors, Treatment Outcome

Distal air space epithelial fluid clearance in near-term rat fetuses is fast and requires endogenous catecholamines.

Knowledge about the conversion of the epithelium in the distal air spaces of the lung from secretion to absorption is imperative to the understanding of postnatal lung development; little such information is available in rats. Distal air space fluid…

A comparison of implanted cardioverter/defibrillator interrogation protocol effectiveness between 2 patients in the ED.

Aspartame exposure and in vitro hippocampal slice excitability and plasticity.

Aspartame (APM) is a low-calorie sweetener recently approved and released for widespread use in the United States. However, concerns still exist that APM consumption may be responsible for adverse neurological and psychological effects in some…

Tags: 1988, Animals, Aspartame/*toxicity, Dipeptides/*toxicity, Electric Stimulation, Electrophysiology, Female, Fountain S B, Fundamental and applied toxicology : official journal of the Society of Toxicology, Hennes S K, Hippocampus/*drug effects/physiopathology, Neuronal Plasticity/*drug effects, Neurons/drug effects, Rats, Teyler T J, Time Factors

A novel coding mechanism for social vocalizations in the lateral amygdala.

The amygdala plays a central role in evaluating the significance of acoustic signals and coordinating the appropriate behavioral responses. To understand how amygdalar responses modulate auditory processing and drive emotional expression, we assessed…

Leading inhibition to neural oscillation is important for time-domain processing in the auditory midbrain.

A number of central auditory neurons exhibit paradoxical latency shift (PLS), a response characterized by longer response latencies at higher sound levels. PLS neurons are known to play a role in target ranging for echolocating bats that emit…

Temporal features of spectral integration in the inferior colliculus: effects of stimulus duration and rise time.

This report examines temporal features of facilitation and suppression that underlie spectrally integrative responses to complex vocal signals. Auditory responses were recorded from 160 neurons in the inferior colliculus (IC) of awake mustached bats.…

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