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Text
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URL Address
<a href="http://doi.org/10.1006/exer.1996.0033" target="_blank" rel="noreferrer noopener">http://doi.org/10.1006/exer.1996.0033</a>
Pages
271–283
Issue
3
Volume
62
Dublin Core
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Title
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Spatial and temporal variations in extracellular matrix of periocular and corneal regions during corneal stromal development.
Publisher
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Experimental eye research
Date
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1996
1996-03
Subject
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*Extracellular Matrix; Animals; Cell Differentiation; Chick Embryo; Collagen/biosynthesis; Cornea/chemistry/*embryology/metabolism; Eye Proteins/analysis; Fibroblasts/cytology; Glycoproteins/analysis; Neural Crest/cytology; Proteoglycans/biosynthesis; Time Factors
Creator
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Doane K J; Ting W H; McLaughlin J S; Birk D E
Description
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The development of the avian corneal stroma occurs in discrete developmental stages. During this sequence of events, the neural crest-derived corneal fibroblast precursor cells are surrounded by distinct extracellular matrices which change both spatially and temporally. To elucidate the role of these matrices, extracellular matrix components in the periocular mesenchyme and cornea were analysed prior to and during migration and differentiation of corneal fibroblasts using antibodies against collagens, proteoglycans and glycoproteins. Previous work has concentrated on the matrix of the corneal stroma rather than the matrix of the periocular mesenchyme. Since the precursors of the corneal fibroblasts are present within the must migrate through the periocular mesenchyme prior to entry into the cornea proper, this environment was fully evaluated. The present study documents the matrix composition of both the cornea and periocular mesenchyme at developmental stages that are prior to and after initiation of corneal invasion by the corneal fibroblast precursors. Variations in matrix molecules comprising both the periocular mesenchyme and cornea were demonstrated. These include changes in the distribution of collagen types I, II, III, IV and VI; the proteoglycans decorin and lumican; as well as the adhesive glycoproteins tenascin, fibronectin and laminin. It is hypothesized that the variations in matrix localization are important in the regulation of cell migration and differentiation during normal corneal development. Any regulation is likely to involve a combination of components found in the extracellular matrices and therefore, a consideration of the matrix rather than isolated components is required.
Identifier
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<a href="http://doi.org/10.1006/exer.1996.0033" target="_blank" rel="noreferrer noopener">10.1006/exer.1996.0033</a>
Rights
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Extracellular Matrix
1996
Animals
Birk D E
Cell Differentiation
Chick Embryo
Collagen/biosynthesis
Cornea/chemistry/*embryology/metabolism
Doane K J
Experimental eye research
Eye Proteins/analysis
Fibroblasts/cytology
Glycoproteins/analysis
McLaughlin J S
Neural Crest/cytology
Proteoglycans/biosynthesis
Time Factors
Ting W H