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Text
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<a href="http://doi.org/10.1016/j.msec.2014.12.062" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.msec.2014.12.062</a>
Pages
663–672
Volume
48
Dublin Core
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Title
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Dewetting based fabrication of fibrous micro-scaffolds as potential injectable cell carriers.
Publisher
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Materials science & engineering. C, Materials for biological applications
Date
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2015
2015-03
Subject
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Animals; Cell retention; Cells; Dewetting; Fibrous micro-constructs; Immobilized/metabolism/transplantation; Injectable constructs; Myocardial Infarction/metabolism/pathology/*therapy; Rats; Sprague-Dawley; Stem Cell Transplantation/*methods; Stem Cells/*metabolism; Tissue engineering and regeneration; Tissue Scaffolds/*chemistry
Creator
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Song Hokyung; Yin Liya; Chilian William M; Newby Bi-Min Zhang
Description
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Although regenerative medicine utilizing tissue scaffolds has made enormous strides in recent years, many constraints still hamper their effectiveness. A limitation of many scaffolds is that they form surface patches, which are not particularly effective for some types of "wounds" that are deep within tissues, e.g., stroke and myocardial infarction. In this study, we reported the generation of fibrous micro-scaffolds feasible for delivering cells by injection into the tissue parenchyma. The micro-scaffolds (widths\textless100mum) were made by dewetting of poly(lactic-co-glycolic acid) thin films containing parallel strips, and cells were seeded to form cell/polymer micro-constructs during or post the micro-scaffold fabrication process. Five types of cells including rat induced vascular progenitor cells were assessed for the formation of the micro-constructs. Critical factors in forming fibrous micro-scaffolds via dewetting of polymer thin films were found to be properties of polymers and supporting substrates, temperature, and proteins in the culture medium. Also, the ability of cells to attach to the micro-scaffolds was essential in forming cell/polymer micro-constructs. Both in vitro and in vivo assessments of injecting these micro-scaffolding constructs showed, as compared to free cells, enhanced cell retention at the injected site, which could lead to improved tissue engineering and regeneration.
Identifier
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<a href="http://doi.org/10.1016/j.msec.2014.12.062" target="_blank" rel="noreferrer noopener">10.1016/j.msec.2014.12.062</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2015
Animals
Cell retention
Cells
Chilian William M
Department of Integrative Medical Sciences
Dewetting
Fibrous micro-constructs
Immobilized/metabolism/transplantation
Injectable constructs
Materials science & engineering. C, Materials for biological applications
Myocardial Infarction/metabolism/pathology/*therapy
NEOMED College of Medicine
Newby Bi-Min Zhang
Rats
Song Hokyung
Sprague-Dawley
Stem Cell Transplantation/*methods
Stem Cells/*metabolism
Tissue engineering and regeneration
Tissue Scaffolds/*chemistry
Yin Liya