1 40 1 Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. URL Address <a href="http://doi.org/10.1586/eci.12.25" target="_blank" rel="noreferrer noopener">http://doi.org/10.1586/eci.12.25</a> Rights Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s). Pages 383-394 Issue 4 Volume 8 Search for Full-text Locate full-text within NEOMED Library's e-journal collections <p>Users with a NEOMED Library login can search for full-text journal articles at the following url: <a href="https://libraryguides.neomed.edu/home">https://libraryguides.neomed.edu/home</a></p> Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Immune response to CMV in solid organ transplant recipients: current concepts and future directions Publisher An entity responsible for making the resource available Expert Review of Clinical Immunology Date A point or period of time associated with an event in the lifecycle of the resource 2012 2012-05 Subject The topic of the resource adaptive immunity; antibody; cd4(+) t-cells; cell-mediated-immunity; CMV; human cytomegalovirus-infection; Immunology; innate immunity; kidney-transplantation; liver-transplantation; long-term; lung transplantation; preemptive therapy; receptor repertoire; recipient; renal-transplant; Toll-like receptor; transplantation; vaccine Creator An entity primarily responsible for making the resource Watkins R R; Lemonovich T L; Razonable R R Description An account of the resource Despite advances in immunosuppression and antiviral therapy, CMV continues to be a significant opportunistic pathogen adversely affecting the outcome of solid organ transplantation (SOT) recipients. While a significant proportion of CMV disease is caused by reactivation of latent virus, the risk is highest among CMV donor+ and recipient- SOT patients. CMV is responsible for both direct (e.g., pneumonitis, colitis) and indirect (e.g., rejection, atherosclerosis) morbidity and mortality. Healthy CMV-seropositive individuals have a high frequency of CMV-specific CD4(+) and CD8(+) T cells that provide immune protection by limiting CMV reactivation and replication. Changes to the innate and adaptive immune system from immunosuppressive therapy following SOT contribute to CMV disease pathogenesis. CMV disease after SOT is associated with poorer outcomes, thus novel strategies to prevent it are an area of active research. In this article, we review the current state of knowledge on the immune response to CMV following SOT. Identifier An unambiguous reference to the resource within a given context <a href="http://doi.org/10.1586/eci.12.25" target="_blank" rel="noreferrer noopener">10.1586/eci.12.25</a> Format The file format, physical medium, or dimensions of the resource Journal Article 2012 Adaptive Immunity antibody cd4(+) t-cells cell-mediated-immunity CMV Department of Internal Medicine Expert Review of Clinical Immunology human cytomegalovirus-infection Immunology Innate immunity Journal Article kidney-transplantation Lemonovich T L liver-transplantation long-term lung transplantation NEOMED College of Medicine preemptive therapy Razonable R R receptor repertoire recipient renal-transplant Toll-like receptor Transplantation Vaccine Watkins R R