1 40 1 Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. URL Address <a href="http://doi.org/10.1002/acm2.12592" target="_blank" rel="noreferrer noopener">http://doi.org/10.1002/acm2.12592</a> Rights Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s). Pages 31-38 Issue 6 Volume 20 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Comparison of multiparametric MRI-based and transrectal ultrasound-based preplans with intraoperative ultrasound-based planning for low dose rate interstitial prostate seed implantation Publisher An entity responsible for making the resource available Journal of Applied Clinical Medical Physics Date A point or period of time associated with an event in the lifecycle of the resource 2019 2019-06 Subject The topic of the resource brachytherapy; LDR; MRI; multiparametric; prostate; TRUS Creator An entity primarily responsible for making the resource Fredman Elisha T; Traughber Bryan J; Gross Andrew; Podder Tarun; Colussi Valdir; Vinkler Robert; Machtay Mitchell; Ellis Rodney J Description An account of the resource PURPOSE: Transrectal ultrasound images are routinely acquired for low dose rate (LDR) prostate brachytherapy dosimetric preplanning (pTRUS), although diagnostic multiparametric magnetic resonance imaging (mpMRI) may serve this purpose as well. We compared the predictive abilities of TRUS vs MRI relative to intraoperative TRUS (iTRUS) to assess the role of mpMRI in brachytherapy preplanning. MATERIALS AND METHODS: Retrospective analysis was performed on 32 patients who underwent iTRUS-guided prostate LDR brachytherapy as either mono- or combination therapy. 56.3% had pTRUS-only volume studies and 43.7% had both 3T-mpMRI and pTRUS preplanning. MRI was used for preplanning and its image fusion with iTRUS was also used for intraoperative guidance of seed placement. Differences in gland volume, seed number, and activity and procedure time were examined, as well as the identification of lesions suspicious for tumor foci. Pearson correlation coefficient and Fisher's Z test were used to estimate associations between continuous measures. RESULTS: There was good correlation of planning volumes between iTRUS and either pTRUS or MRI (r = 0.89, r = 0.77), not impacted by the addition of hormonal therapy (P = 0.65, P = 0.33). Both consistently predicted intraoperative seed number (r = 0.87, r = 0.86). MRI/TRUS fusion did not significantly increase surgical or anesthesia time (P = 0.10, P = 0.46). mpMRI revealed suspicious focal lesions in 11 of 14 cases not visible on pTRUS, that when correlated with histopathology, were incorporated into the plan. CONCLUSIONS: Relative to pTRUS, MRI yielded reliable preplanning measures, supporting the role of MRI-only LDR treatment planning. mpMRI carries numerous diagnostic, staging and preplanning advantages that facilitate better patient selection and delivery of novel dose escalation and targeted therapy, with no additional surgical or anesthesia time. Prospective studies assessing its impact on treatment planning and delivery can serve to establish mpMRI as the standard of care in LDR prostate brachytherapy planning. Identifier An unambiguous reference to the resource within a given context <a href="http://doi.org/10.1002/acm2.12592" target="_blank" rel="noreferrer noopener">10.1002/acm2.12592</a> 2019 brachytherapy Colussi Valdir Ellis Rodney J Fredman Elisha T Gross Andrew Journal of Applied Clinical Medical Physics June 2019 Update LDR Machtay Mitchell MRI multiparametric NEOMED College of Medicine NEOMED College of Medicine Student NEOMED Student Publications Podder Tarun Prostate Traughber Bryan J TRUS Vinkler Robert