1
40
22
-
Hyperlink
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URL
10.1002/jor.25550
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The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
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The Development of a Trauma Resiliency Scale (tRS-18)
Creator
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Margaret A Sinkler
Andrew Alejo
Julie Agel
Sarah Hendrickson
Mary A Breslin
Heather A Vallier
Date
A point or period of time associated with an event in the lifecycle of the resource
2023
Description
An account of the resource
Resiliency consists of three core components, which include presence of adversity, protective factors to overcome adversity, and positive outcomes or growth. Therefore, resiliency aligns with the trauma recovery process. This paper describes development of the Trauma Resiliency Scale (tRS) to quantify the resiliency of trauma patients upon presentation and during recovery. Scale items were proposed and reviewed by an expert panel. Group construct validity testing was performed using both individual and focus group feedback with item analysis. Reliability was measured with test-retest administered 14-days apart and evaluated with intraclass correlation coefficient. 123-items were initially proposed. Following item categorizing, a preliminary 17-item questionnaire was created. The questionnaire was administered to 40 individual participants and a trauma survivor focus group to evaluate construct validity. Following group construct testing, an 18-item Trauma Resiliency Scale (tRS-18) was proposed. 24 participants were given the tRS-18 twice, 14 days apart to establish test-retest. Sixteen of the eighteen questions had an intraclass correlation > 0.7 (0.793-0.949). The remaining two questions underperformed based on the ICC (0.592 and 0.493) and were manually evaluated for inclusion. The final tRS-18 is a brief, self-administered measure of resiliency designed specifically for trauma patients. Sound psychometric properties including face validity, construct validity, and reliability of the instrument have been demonstrated. The tRS-18 may quantify resiliency at any time point with potential to be predictive of progress during recovery. Level of Evidence III, prognostic This article is protected by copyright. All rights reserved.
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J Orthop Res
. 2023 Mar 14. doi: 10.1002/jor.25550. Online ahead of print.
Language
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English
2023
Clinical
Rehabilitation
trauma
Treatment
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.ymgme.2020.09.006" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.ymgme.2020.09.006</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
ISSN
1096-7206 1096-7192
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<a href="http://neomed.idm.oclc.org/login?url=http://doi.org/10.1016/j.ymgme.2020.09.006" target="_blank" rel="noreferrer noopener">NEOMED Full-text Holding (if available) - Proxy DOI: 10.1016/j.ymgme.2020.09.006</a>
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Update Year & Number
October 2020 List
NEOMED College
NEOMED College of Medicine
NEOMED Department
Department of Pediatrics
Department of General Surgery
NEOMED Student Publications
Affiliated Hospital
Akron Children's Hospital
Summa Health System Akron City Hospital
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
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Biochemical phenotype and its relationship to treatment in 16 individuals with PCCB c.1606A > G (p.Asn536Asp) variant propionic acidemia.
Publisher
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Molecular Genetics and Metabolism
Date
A point or period of time associated with an event in the lifecycle of the resource
2020
2020-10-03
Subject
The topic of the resource
Treatment; Phenotype; Biomarker; Propionic acidemia
Creator
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Wenger O;Brown M;Smith B;Chowdhury D;Crosby AH;Baple EL;Yoder M;Laxen W;Tortorelli S;Strauss KA
Description
An account of the resource
Propionic acidemia (PA) is caused by inherited deficiency of mitochondrial propionyl-CoA carboxylase (PCC) and results in significant neurodevelopmental and cardiac morbidity. However, relationships among therapeutic intervention, biochemical markers, and disease progression are poorly understood. Sixteen individuals homozygous for PCCB c.1606A > G (p.Asn536Asp) variant PA participated in a two-week suspension of therapy. Standard metabolic markers (plasma amino acids, blood spot methylcitrate, plasma/urine acylcarnitines, urine organic acids) were obtained before and after stopping treatment. These same markers were obtained in sixteen unaffected siblings. Echocardiography and electrocardiography were obtained from all subjects. We characterized the baseline biochemical phenotype of untreated PCCB c.1606A > G homozygotes and impact of treatment on PCC deficiency biomarkers. Therapeutic regimens varied widely. Suspension of therapy did not significantly alter branched chain amino acid levels, their alpha-ketoacid derivatives, or urine ketones. Carnitine supplementation significantly increased urine propionylcarnitine and its ratio to total carnitine. Methylcitrate blood spot and urine levels did not correlate with other biochemical measures or cardiac outcomes. Treatment of PCCB c.1606A > G homozygotes with protein restriction, prescription formula, and/or various dietary supplements has a limited effect on core biomarkers of PCC deficiency. These patients require further longitudinal study with standardized approaches to better understand the relationship between biomarkers and disease burden.
Identifier
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<a href="http://doi.org/10.1016/j.ymgme.2020.09.006" target="_blank" rel="noreferrer noopener">10.1016/j.ymgme.2020.09.006</a>
Format
The file format, physical medium, or dimensions of the resource
journalArticle
2020
Baple EL
Biomarker
Brown M
Chowdhury D
Crosby AH
Department of General Surgery
Department of Pediatrics
journalArticle
Laxen W
Molecular Genetics and Metabolism
NEOMED College of Medicine
NEOMED Student Publications
October 2020 List
Phenotype
Propionic acidemia
Smith B
Strauss KA
Tortorelli S
Treatment
Wenger O
Yoder M
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.jor.2020.01.021" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.jor.2020.01.021</a>
Pages
144-146
Volume
20
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<a href="http://ezproxy.neomed.idm.oclc.org/login?url=http://doi.org/10.1016/j.jor.2020.01.021" target="_blank" rel="noreferrer noopener">NEOMED Full-text Holding (if available) - Proxy DOI: 10.1016/j.jor.2020.01.021</a>
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Update Year & Number
March 2020 Update
NEOMED College
NEOMED College of Medicine
NEOMED Department
NEOMED Student Publications
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The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
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Teres minor and quadrilateral space syndrome: A review.
Publisher
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Journal of orthopaedics
Date
A point or period of time associated with an event in the lifecycle of the resource
2020
2020-08
Subject
The topic of the resource
Treatment; Surgical; Quadrilateral Space Syndrome; Teres minor; Neurogenic Quadrilateral Space Syndrome; nQSS; PCHA; Posterior Circumflex Humeral Artery; QS; QSS; Quadrilateral Space; Quadrilateral Space Syndrome; Vascular Quadrilateral Space Syndrome; vQSS
Creator
An entity primarily responsible for making the resource
Dalagiannis Nicholas; Tranovich Meaghan; Ebraheim Nabil
Description
An account of the resource
The teres minor is one of four rotator cuff muscles that is involved in many shoulder pathologies. The integrity of the teres minor can be indicative of treatment success for disorders including rotator cuff tears, impingement syndrome, and quadrangular space syndrome. Quadrangular or quadrilateral space syndrome is a debilitating disorder that may require surgical intervention in chronic cases and can lead to atrophy of the teres minor. A review of the diagnostic techniques and treatment methods for disorders involving teres minor, with a focus on quadrilateral space syndrome, are presented in order to summarize the current understanding of these pathologies.
Identifier
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<a href="http://doi.org/10.1016/j.jor.2020.01.021" target="_blank" rel="noreferrer noopener">10.1016/j.jor.2020.01.021</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
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Journal Article
2020
Dalagiannis Nicholas
Ebraheim Nabil
Journal of orthopaedics
NEOMED College of Medicine Student
NEOMED Student Publications
Neurogenic Quadrilateral Space Syndrome
nQSS
PCHA
Posterior Circumflex Humeral Artery
QS
QSS
Quadrilateral Space
Quadrilateral Space Syndrome
Surgical
Teres minor
Tranovich Meaghan
Treatment
Vascular Quadrilateral Space Syndrome
vQSS
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.jaccas.2019.10.003" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.jaccas.2019.10.003</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
675-677
Issue
4
Volume
1
ISSN
2666-0849
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<a href="http://ezproxy.neomed.idm.oclc.org/login?url=http://doi.org/10.1016/j.jaccas.2019.10.003" target="_blank" rel="noreferrer noopener">NEOMED Full-text Holding (if available) - Proxy DOI: 10.1016/j.jaccas.2019.10.003</a>
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Update Year & Number
January 2020 Update
NEOMED College
NEOMED College of Medicine
NEOMED Department
NEOMED Student Publications; NEOMED College of Medicine Student
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
High-Grade Spindle Cell Sarcoma of the Heart: A Rare Cause of Mitral Valve Disease
Publisher
An entity responsible for making the resource available
JACC: Case Reports
Date
A point or period of time associated with an event in the lifecycle of the resource
2019
2019-12-01
Subject
The topic of the resource
cancer; cardiac magnetic resonance; echocardiography; Intermediate; mitral valve; thrombus; treatment
Creator
An entity primarily responsible for making the resource
Natarajan Jay P; Mahenthiran Ashorne K; Ranginani Anil K; Mahenthiran Jo
Description
An account of the resource
A young female with pulmonary congestion suspected to be secondary to mitral valve disease with left atrial appendage thrombus was given therapy for heart failure and anticoagulation. Subsequent multimodality imaging with echocardiography and magnetic resonance imaging established an accurate but rare diagnosis of spindle cell sarcoma of the heart. (Level of Difficulty: Intermediate.)
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/j.jaccas.2019.10.003" target="_blank" rel="noreferrer noopener">10.1016/j.jaccas.2019.10.003</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article
2019
Cancer
cardiac magnetic resonance
Echocardiography
Intermediate
JACC: Case Reports
January 2020 Update
Journal Article
Mahenthiran Ashorne K
Mahenthiran Jo
mitral valve
Natarajan Jay P
NEOMED College of Medicine Student
NEOMED Student Publications
Ranginani Anil K
thrombus
Treatment
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1136/annrheumdis-2019-216040" target="_blank" rel="noreferrer noopener">http://doi.org/10.1136/annrheumdis-2019-216040</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
1722-1731
Issue
12
Volume
78
ISSN
1468-2060
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<a href="http://ezproxy.neomed.idm.oclc.org/login?url=http://doi.org/10.1136/annrheumdis-2019-216040" target="_blank" rel="noreferrer noopener">NEOMED Full-text Holding (if available) - Proxy DOI: 10.1136/annrheumdis-2019-216040</a>
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Title
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Emergent high fatality lung disease in systemic juvenile arthritis
Publisher
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Annals Of The Rheumatic Diseases
Date
A point or period of time associated with an event in the lifecycle of the resource
2019
2019-12
Subject
The topic of the resource
treatment; inflammation; adult onset still's disease; DMARDs (biologic); juvenile idiopathic arthritis
Creator
An entity primarily responsible for making the resource
Saper Vivian E; Chen Guangbo; Deutsch Gail H; Guillerman R Paul; Birgmeier Johannes; Jagadeesh Karthik; Canna Scott; Schulert Grant; Deterding Robin; Xu Jianpeng; Leung Ann N; Bouzoubaa Layla; Abulaban Khalid; Baszis Kevin; Behrens Edward M; Birmingham James; Casey Alicia; Cidon Michal; Cron Randy Q; De Aliva; De Benedetti Fabrizio; Ferguson Ian; Fishman Martha P; Goodman Steven I; Graham T Brent; Grom Alexei A; Haines Kathleen; Hazen Melissa; Henderson Lauren A; Ho Assunta; Ibarra Maria; Inman Christi J; Jerath Rita; Khawaja Khulood; Kingsbury Daniel J; Klein-Gitelman Marisa; Lai Khanh; Lapidus Sivia; Lin Clara; Lin Jenny; Liptzin Deborah R; Milojevic Diana; Mombourquette Joy; Onel Karen; Ozen Seza; Perez Maria; Phillippi Kathryn; Prahalad Sampath; Radhakrishna Suhas; Reinhardt Adam; Riskalla Mona; Rosenwasser Natalie; Roth Johannes; Schneider Rayfel; Schonenberg-Meinema Dieneke; Shenoi Susan; Smith Judith A; Sönmez Hafize Emine; Stoll Matthew L; Towe Christopher; Vargas Sara O; Vehe Richard K; Young Lisa R; Yang Jacqueline; Desai Tushar; Balise Raymond; Lu Ying; Tian Lu; Bejerano Gill; Davis Mark M; Khatri Purvesh; Mellins Elizabeth D; Childhood Arthritis and Rheumatology Research Alliance Registry Investigators
Description
An account of the resource
OBJECTIVE: To investigate the characteristics and risk factors of a novel parenchymal lung disease (LD), increasingly detected in systemic juvenile idiopathic arthritis (sJIA). METHODS: In a multicentre retrospective study, 61 cases were investigated using physician-reported clinical information and centralised analyses of radiological, pathological and genetic data. RESULTS: LD was associated with distinctive features, including acute erythematous clubbing and a high frequency of anaphylactic reactions to the interleukin (IL)-6 inhibitor, tocilizumab. Serum ferritin elevation and/or significant lymphopaenia preceded LD detection. The most prevalent chest CT pattern was septal thickening, involving the periphery of multiple lobes ± ground-glass opacities. The predominant pathology (23 of 36) was pulmonary alveolar proteinosis and/or endogenous lipoid pneumonia (PAP/ELP), with atypical features including regional involvement and concomitant vascular changes. Apparent severe delayed drug hypersensitivity occurred in some cases. The 5-year survival was 42%. Whole exome sequencing (20 of 61) did not identify a novel monogenic defect or likely causal PAP-related or macrophage activation syndrome (MAS)-related mutations. Trisomy 21 and young sJIA onset increased LD risk. Exposure to IL-1 and IL-6 inhibitors (46 of 61) was associated with multiple LD features. By several indicators, severity of sJIA was comparable in drug-exposed subjects and published sJIA cohorts. MAS at sJIA onset was increased in the drug-exposed, but was not associated with LD features. CONCLUSIONS: A rare, life-threatening lung disease in sJIA is defined by a constellation of unusual clinical characteristics. The pathology, a PAP/ELP variant, suggests macrophage dysfunction. Inhibitor exposure may promote LD, independent of sJIA severity, in a small subset of treated patients. Treatment/prevention strategies are needed.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1136/annrheumdis-2019-216040" target="_blank" rel="noreferrer noopener">10.1136/annrheumdis-2019-216040</a>
PMID: 31562126
Format
The file format, physical medium, or dimensions of the resource
Journal Article
2019
Abulaban Khalid
adult onset still's disease
Akron Children's Hospital
Annals of the rheumatic diseases
Balise Raymond
Baszis Kevin
Behrens Edward M
Bejerano Gill
Birgmeier Johannes
Birmingham James
Bouzoubaa Layla
Canna Scott
Casey Alicia
Chen Guangbo
Childhood Arthritis and Rheumatology Research Alliance Registry Investigators
Cidon Michal
Cron Randy Q
Davis Mark M
De Aliva
De Benedetti Fabrizio
Department of Pediatrics
Desai Tushar
Deterding Robin
Deutsch Gail H
DMARDs (biologic)
Ferguson Ian
Fishman Martha P
Goodman Steven I
Graham T Brent
Grom Alexei A
Guillerman R Paul
Haines Kathleen
Hazen Melissa
Henderson Lauren A
Ho Assunta
Ibarra Maria
Inflammation
Inman Christi J
Jagadeesh Karthik
Jerath Rita
Journal Article
juvenile idiopathic arthritis
Khatri Purvesh
Khawaja Khulood
Kingsbury Daniel J
Klein-Gitelman Marisa
Lai Khanh
Lapidus Sivia
Leung Ann N
Lin Clara
Lin Jenny
Liptzin Deborah R
Lu Ying
Mellins Elizabeth D
Milojevic Diana
Mombourquette Joy
NEOMED College of Medicine
November 2019 Update
Onel Karen
Ozen Seza
Perez Maria
Phillippi Kathryn
Prahalad Sampath
Radhakrishna Suhas
Reinhardt Adam
Riskalla Mona
Rosenwasser Natalie
Roth Johannes
Saper Vivian E
Schneider Rayfel
Schonenberg-Meinema Dieneke
Schulert Grant
Shenoi Susan
Smith Judith A
Sönmez Hafize Emine
Stoll Matthew L
Tian Lu
Towe Christopher
Treatment
Vargas Sara O
Vehe Richard K
Xu Jianpeng
Yang Jacqueline
Young Lisa R
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1038/oby.2005.106" target="_blank" rel="noreferrer noopener">http://doi.org/10.1038/oby.2005.106</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
917-927
Issue
5
Volume
13
Search for Full-text
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Transtheoretical Model-chronic Disease Care For Obesity In Primary Care: A Randomized Trial
Publisher
An entity responsible for making the resource available
Obesity Research
Date
A point or period of time associated with an event in the lifecycle of the resource
2005
2005-05
Subject
The topic of the resource
chronic disease; clinical-trials; cognitive-behavioral therapy; dietary-fat intake; Endocrinology & Metabolism; exercise behavior; intervention; motivational readiness; Nutrition & Dietetics; physical-activity; program; randomized controlled trial; self-efficacy; services task-force; treatment; weight management; weight loss
Creator
An entity primarily responsible for making the resource
Logue E E; Sutton K; Jarjoura D; Smucker W; Baughman K; Capers C
Description
An account of the resource
Objective: To compare health benefits achieved in a transtheoretical model-chronic disease (TM-CD) minimal intervention for obesity vs. augmented usual care (AUC). Research Method and Procedures: This was a 2-year, randomized clinical trial with overweight or obese men and women from 15 primary care sites. AUC (n = 336) included dietary and exercise advice, prescriptions, and three 24-hour dietary recalls every 6 months. TM-CD care (n = 329) included AUC elements plus "stage of change" (SOC) assessments for five target behaviors every other month, mailed SOC and target behavior-matched-workbooks, and monthly telephone calls from a weight-loss advisor. Weight change was the primary outcome. Results: Repeated measures models under the missing at random assumption yielded nonsignificant adjusted differences between. the AUC and TM-CD groups for weight change, waist circumference, energy intake or expenditure, blood pressure, and blood lipids. The pattern of change over time suggested that TM-CD participants were trying harder to impact target behaviors during the first 6 to 12 months of the trial but relapsed afterward. Sixty percent of trial participants maintained their baseline weights for 18 to 24 months. Discussion: A combination of mailed patient materials and monthly telephone calls based on, the transtheoretical model and some elements of chronic disease care is not powerful enough, relative to AUC, to alter target behaviors among overweight primary care patients in an obesogenic environment. AUC may be sufficient to maintain weights among at-risk primary care patients.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1038/oby.2005.106" target="_blank" rel="noreferrer noopener">10.1038/oby.2005.106</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
2005
Baughman K
Capers C
Chronic Disease
clinical-trials
cognitive-behavioral therapy
Department of Family & Community Medicine
dietary-fat intake
Endocrinology & Metabolism
exercise behavior
Intervention
Jarjoura D
Journal Article or Conference Abstract Publication
Logue E E
motivational readiness
NEOMED College of Medicine
Nutrition & Dietetics
Obesity Research
physical-activity
program
randomized controlled trial
self-efficacy
services task-force
Smucker W
Sutton K
Treatment
Weight Loss
weight management
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.2174/156800912803987896" target="_blank" rel="noreferrer noopener">http://doi.org/10.2174/156800912803987896</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
1191-1232
Issue
9
Volume
12
Search for Full-text
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Dietary Phytochemicals In The Chemoprevention And Treatment Of Hepatocellular Carcinoma: In Vivo Evidence, Molecular Targets, And Clinical Relevance
Publisher
An entity responsible for making the resource available
Current Cancer Drug Targets
Date
A point or period of time associated with an event in the lifecycle of the resource
2012
2012-11
Subject
The topic of the resource
acid phenethyl ester; altered hepatic foci; black tea; carcinoma; Chemoprevention; dietary; diethylnitrosamine-induced hepatocarcinogenesis; hepatocarcinogenesis; hepatocellular; implanted; liver cancer; liver preneoplastic foci; model; multiorgan carcinogenesis model; nitrosodiethylamine-induced; nude-mice; Oncology; phenobarbital-induced hepatocarcinogenesis; phytochemicals; polyphenols; resistant hepatocyte; treatment
Creator
An entity primarily responsible for making the resource
Bishayee A; Thoppil R J; Waghray A; Kruse J A; Novotny N A; Darvesh A S
Description
An account of the resource
Hepatocellular carcinoma (HCC), one of the most common and lethal cancers, is a growing menace in modern society. Until recently, the majority of detected cases of liver cancer have been found in the developing nations of Asia and Africa; however, its occurrence has significantly increased in the United States. HCC occurs due to several etiologies, such as alcoholism, dietary carcinogens, iron overload, viral hepatitis, as well as several hepatic chronic diseases. In view of the limited treatment options, such as surgery and transplantation, a critical need exists to examine alternative approaches. The use of phytochemicals obtained from dietary sources provides a novel and fascinating preventive and therapeutic approach against HCC. Dietary phytochemicals possess potent antioxidant and anti-inflammatory properties which are extremely critical to combat the significant oxidative stress and inflammation implicated in liver cancer. An impressive number of phytochemicals have shown considerable promise as candidates for the prevention and treatment of HCC. In this article, we systematically review the in vivo pre-clinical evidence documenting the chemopreventive and therapeutic potential of several important dietary phytochemicals in HCC. This review critically examines the molecular mechanisms of the pharmacological effects of the aforementioned animal studies. Clinical and epidemiological studies are also highlighted in this review. Emerging issues such as bioavailability, dose optimization, targeted drug delivery, role of botanical extracts and synergy are also discussed. Finally, current challenges, limitations, future directions, innovative concepts and novel hypotheses for the use of dietary phytochemicals in the chemoprevention and amelioration of human HCC are presented.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.2174/156800912803987896" target="_blank" rel="noreferrer noopener">10.2174/156800912803987896</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
2012
acid phenethyl ester
altered hepatic foci
Bishayee A
black tea
Carcinoma
Chemoprevention
Current cancer drug targets
Darvesh A S
Department of Pharmaceutical Sciences
Dietary
diethylnitrosamine-induced hepatocarcinogenesis
Hepatocarcinogenesis
Hepatocellular
Implanted
Journal Article or Conference Abstract Publication
Kruse J A
Liver cancer
liver preneoplastic foci
model
multiorgan carcinogenesis model
NEOMED College of Pharmacy
nitrosodiethylamine-induced
Novotny N A
nude-mice
oncology
phenobarbital-induced hepatocarcinogenesis
phytochemicals
Polyphenols
resistant hepatocyte
Thoppil R J
Treatment
Waghray A
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
n/a
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
462-+
Issue
10
Volume
18
Search for Full-text
Locate full-text within NEOMED Library's e-journal collections
<p>Users with a NEOMED Library login can search for full-text journal articles at the following url: <a href="https://libraryguides.neomed.edu/home">https://libraryguides.neomed.edu/home</a></p>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Management Of Community-acquired Pneumonia: An Appropriate-use Tool
Publisher
An entity responsible for making the resource available
Infections in Medicine
Date
A point or period of time associated with an event in the lifecycle of the resource
2001
2001-10
Subject
The topic of the resource
adults; antimicrobial resistance; azithromycin; community-acquired; guidelines; Infectious Diseases; levofloxacin; outcomes; pneumonia; resistant streptococcus-pneumoniae; surveillance; therapy; treatment; united-states
Creator
An entity primarily responsible for making the resource
File T M; Bartlett J G; Bernstein A; Martinez F J
Identifier
An unambiguous reference to the resource within a given context
n/a
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
2001
adults
Antimicrobial resistance
azithromycin
Bartlett J G
Bernstein A
Community-acquired
File T M
guidelines
Infections in Medicine
Infectious Diseases
Levofloxacin
Martinez F J
outcomes
Pneumonia
resistant streptococcus-pneumoniae
surveillance
therapy
Treatment
united-states
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.2174/156800912803987896" target="_blank" rel="noreferrer noopener">http://doi.org/10.2174/156800912803987896</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
1191-1232
Issue
9
Volume
12
Search for Full-text
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Dietary Phytochemicals In The Chemoprevention And Treatment Of Hepatocellular Carcinoma: In Vivo Evidence, Molecular Targets, And Clinical Relevance
Publisher
An entity responsible for making the resource available
Current Cancer Drug Targets
Date
A point or period of time associated with an event in the lifecycle of the resource
2012
2012-11
Subject
The topic of the resource
acid phenethyl ester; altered hepatic foci; black tea; carcinoma; chemoprevention; dietary; diethylnitrosamine-induced hepatocarcinogenesis; hepatocarcinogenesis; hepatocellular; implanted; liver cancer; liver preneoplastic foci; model; multiorgan carcinogenesis model; nitrosodiethylamine-induced; nude-mice; Oncology; phenobarbital-induced hepatocarcinogenesis; phytochemicals; polyphenols; resistant hepatocyte; treatment
Creator
An entity primarily responsible for making the resource
Bishayee A; Thoppil R J; Waghray A; Kruse J A; Novotny N A; Darvesh A S
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.2174/156800912803987896" target="_blank" rel="noreferrer noopener">10.2174/156800912803987896</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
2012
acid phenethyl ester
altered hepatic foci
Bishayee A
black tea
Carcinoma
Chemoprevention
Current cancer drug targets
Darvesh A S
Department of Pharmaceutical Sciences
Dietary
diethylnitrosamine-induced hepatocarcinogenesis
Hepatocarcinogenesis
Hepatocellular
Implanted
Kruse J A
Liver cancer
liver preneoplastic foci
model
multiorgan carcinogenesis model
NEOMED College of Pharmacy
nitrosodiethylamine-induced
Novotny N A
nude-mice
oncology
phenobarbital-induced hepatocarcinogenesis
phytochemicals
Polyphenols
resistant hepatocyte
Thoppil R J
Treatment
Waghray A
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1385/jcd:5:4:375" target="_blank" rel="noreferrer noopener">http://doi.org/10.1385/jcd:5:4:375</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
375-381
Issue
4
Volume
5
Search for Full-text
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Physician treatment of osteoporosis in response to heel ultrasound bone mineral density reports
Publisher
An entity responsible for making the resource available
Journal of Clinical Densitometry
Date
A point or period of time associated with an event in the lifecycle of the resource
2002
2002
Subject
The topic of the resource
treatment; osteoporosis; management; Endocrinology & Metabolism; classification; postmenopausal women; quantitative ultrasound; bone density report; densitometry; heel ultrasound; hip fracture
Creator
An entity primarily responsible for making the resource
Boyd J L; Holcomb J P; Rothenberg R J
Description
An account of the resource
Optimal information that should be included in ultrasound (US) heel bone mineral density (BMD) reports is not known. If additional information about further evaluation of patients with low heel BMD were included in reports, would responses for treatment improve? We screened people at health fairs using the Sahara heel US machine. For those with a T-score of less than or equal to -1.0, letters were sent to their primary care physician notifying them of the result. Physicians were randomly assigned to (1) a standard letter, which recommended central bone density screening (dual X-ray absorptiometry [DXA]) and treatment if the BMD was low; or (2) an extended letter, which also outlined treatment strategies based on recommended subsequent central DXA scan results for a T-score of <-1.50 and also if < -2.00. The extended letter only increased the frequency of DXA testing from 30.1 to 37.2% (not a significant increase). Of 88 people with heel BMD: less than or equal to -1.00 and not previously on any treatment, 25 of 45 (56%) were treated (calcium, estrogens, bisphosphonates, or calcitonin or a combination) after physicians received a standard letter and 30 of 43 (70%) after an extended letter (one-sided p = 0.084). Of people with T less than or equal to -1.9, and initially taking nothing more than calcium, 5 of 36 (13.9%) received additional treatment after physicians received a standard letter vs 9 of 41 (22.0%) after an extended letter (one-sided p = 0.180). For those with T less than or equal to -1.0 because of the screen 25 of 197 (12.7%) received additional treatment. One hundred forty-six of 194 (75%) individuals and received treatment with calcium or other medications, and 74 of 173 (43%) of individuals before screening and 141 of 195 (72%) after physicians received letters took calcium. Physicians regarded calcium alone as adequate treatment in many cases. There was no marked increase in treatment when additional information was provided to physicians regarding evaluation and treatment for low US heel BMD results.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1385/jcd:5:4:375" target="_blank" rel="noreferrer noopener">10.1385/jcd:5:4:375</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
2002
bone density report
Boyd J L
classification
Densitometry
Endocrinology & Metabolism
heel ultrasound
hip fracture
Holcomb J P
Journal Article or Conference Abstract Publication
Journal of Clinical Densitometry
Management
Osteoporosis
postmenopausal women
quantitative ultrasound
Rothenberg R J
Treatment
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1200/jco.2007.15.0235" target="_blank" rel="noreferrer noopener">http://doi.org/10.1200/jco.2007.15.0235</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
778-785
Issue
5
Volume
26
Search for Full-text
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Preoperative chemotherapy: Updates of National Surgical Adjuvant Breast and Bowel Project Protocols B-18 and B-27
Publisher
An entity responsible for making the resource available
Journal of Clinical Oncology
Date
A point or period of time associated with an event in the lifecycle of the resource
2008
2008-02
Subject
The topic of the resource
cancer patients; chemotherapy; competing risk; conservative treatment; estrogen-receptor status; expressing estrogen; induction; multimodal; neoadjuvant chemotherapy; Oncology; radiation-therapy; treatment; tumor response
Creator
An entity primarily responsible for making the resource
Rastogi P; Anderson S J; Bear H D; Geyer C E; Kahlenberg M S; Robidoux A; Margolese R G; Hoehn J L; Vogel V G; Dakhil S R; Tamkus D; King K M; Pajon E R; Wright M J; Robert J; Paik S; Mamounas E P; Wolmark N
Description
An account of the resource
Purpose National Surgical Adjuvant Breast and Bowel Project (NSABP) Protocol B-18 was designed to determine whether four cycles of doxorubicin and cyclophosphamide (AC) administered preoperatively improved breast cancer disease-free survival (DFS) and overall survival (OS) compared with AC administered postoperatively. Protocol B-27 was designed to determine the effect of adding docetaxel (T) to preoperative AC on tumor response rates, DFS, and OS. Patients and Methods Analyses were limited to eligible patients. In B-18, 751 patients were assigned to receive preoperative AC, and 742 patients were assigned to receive postoperative AC. In B-27, 784 patients were assigned to receive preoperative AC followed by surgery, 783 patients were assigned to AC followed by T and surgery, and 777 patients were assigned to AC followed by surgery and then T. Results Results from B-18 show no statistically significant differences in DFS and OS between the two groups. However, there were trends in favor of preoperative chemotherapy for DFS and OS in women less than 50 years old (hazard ratio [HR] = 0.85, P = .09 for DFS; HR = 0.81, P = .06 for OS). DFS conditional on being event free for 5 years also demonstrated a strong trend in favor of the preoperative group (HR = 0.81, P = .053). Protocol B-27 results demonstrated that the addition of T to AC did not significantly impact DFS or OS. Preoperative T added to AC significantly increased the proportion of patients having pathologic complete responses (pCRs) compared with preoperative AC alone (26% v 13%, respectively; P < .0001). In both studies, patients who achieved a pCR continue to have significantly superior DFS and OS outcomes compared with patients who did not. Conclusion B-18 and B-27 demonstrate that preoperative therapy is equivalent to adjuvant therapy. B-27 also showed that the addition of preoperative taxanes to AC improves response.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1200/jco.2007.15.0235" target="_blank" rel="noreferrer noopener">10.1200/jco.2007.15.0235</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article
2008
Anderson S J
Bear H D
Cancer Patients
Chemotherapy
competing risk
conservative treatment
Dakhil S R
estrogen-receptor status
expressing estrogen
Geyer C E
Hoehn J L
induction
Journal Article
Journal of Clinical Oncology
Kahlenberg M S
King K M
Mamounas E P
Margolese R G
multimodal
neoadjuvant chemotherapy
oncology
Paik S
Pajon E R
radiation-therapy
Rastogi P
Robert J
Robidoux A
Tamkus D
Treatment
tumor response
Vogel V G
Wolmark N
Wright M J
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1007/s40596-019-01089-9" target="_blank" rel="noreferrer noopener">http://doi.org/10.1007/s40596-019-01089-9</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Search for Full-text
Locate full-text within NEOMED Library's e-journal collections
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Characteristics Associated with Depression and Suicidal Thoughts Among Medical Residents: Results from the DEPRESS-Ohio Study
Publisher
An entity responsible for making the resource available
Academic Psychiatry: The Journal of the American Association of Directors of Psychiatric Residency Training and the Association for Academic Psychiatry
Date
A point or period of time associated with an event in the lifecycle of the resource
2019
2019-07
Subject
The topic of the resource
depression; Licensure; No terms assigned; Residents; Treatment; Wellness
Creator
An entity primarily responsible for making the resource
Levy Alan B; Nahhas Ramzi W; Sampang Suzanne; Jacobs Karen; Weston Christina; Cerny-Suelzer Cathleen; Riese Amy; Munetz Mark R; Shaw Janet
Description
An account of the resource
OBJECTIVE: This study describes the characteristics that are associated with depression in residents and also examines resident perception of available mental health support. METHODS: Residents and their program directors from each of 10 specialties across all academic training institutions in Ohio were electronically surveyed over a 2-month period. Generalized logistic regression was used to test for association between risk factors and depression and, among depressed residents, with suicidal thoughts. RESULTS: Using the PHQ-9, 19% of residents met criteria for at least moderate depression and 31.1% of depressed residents had suicidal thoughts. Over 70% of depressed residents were not receiving treatment, including 70% of depressed residents with suicidal thoughts. Residents who were unaware of wellness programming or did not believe their program director would be supportive of a depressed resident were significantly more likely to be depressed. Residents who believed depression treatment would negatively impact medical licensure were significantly more likely to be depressed. Male program directors and those in their position for fewer than 5 years were significantly more likely to have depressed residents in their program. CONCLUSIONS: A substantial proportion of depressed residents have suicidal thoughts, and most are not receiving treatment. Depressed residents may perceive the availability of support from their program director differently than their non-depressed colleagues, and may perceive greater risk to medical licensure if they seek treatment.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1007/s40596-019-01089-9" target="_blank" rel="noreferrer noopener">10.1007/s40596-019-01089-9</a>
2019
Academic Psychiatry: The Journal of the American Association of Directors of Psychiatric Residency Training and the Association for Academic Psychiatry
Cerny-Suelzer Cathleen
Department of Psychiatry
Depression
Jacobs Karen
Levy Alan B
Licensure
Munetz Mark R
Nahhas Ramzi W
NEOMED College of Medicine
No terms assigned
Residents
Riese Amy
Sampang Suzanne
September 2019 Update
Shaw Janet
Treatment
Wellness
Weston Christina
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1093/cid/ciy874" target="_blank" rel="noreferrer noopener">http://doi.org/10.1093/cid/ciy874</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
895-902
Issue
6
Volume
68
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Clinical Practice Guidelines by the Infectious Diseases Society of America: 2018 Update on Diagnosis, Treatment, Chemoprophylaxis, and Institutional Outbreak Management of Seasonal Influenzaa.
Publisher
An entity responsible for making the resource available
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
Date
A point or period of time associated with an event in the lifecycle of the resource
2019
2019-03
Subject
The topic of the resource
treatment; influenza; diagnostic testing; chemoprophylaxis; institutional outbreaks; seasonal
Creator
An entity primarily responsible for making the resource
Uyeki Timothy M; Bernstein Henry H; Bradley John S; Englund Janet A; File Thomas M; Fry Alicia M; Gravenstein Stefan; Hayden Frederick G; Harper Scott A; Hirshon Jon Mark; Ison Michael G; Johnston B Lynn; Knight Shandra L; McGeer Allison; Riley Laura E; Wolfe Cameron R; Alexander Paul E; Pavia Andrew T
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1093/cid/ciy874" target="_blank" rel="noreferrer noopener">10.1093/cid/ciy874</a>
2019
Alexander Paul E
Bernstein Henry H
Bradley John S
Chemoprophylaxis
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
Department of Family & Community Medicine
Department of Internal Medicine
diagnostic testing
Englund Janet A
File Thomas M
Fry Alicia M
Gravenstein Stefan
Harper Scott A
Hayden Frederick G
Hirshon Jon Mark
Influenza
institutional outbreaks
Ison Michael G
Johnston B Lynn
Knight Shandra L
McGeer Allison
NEOMED College of Medicine
Pavia Andrew T
Riley Laura E
seasonal
Treatment
Uyeki Timothy M
Wolfe Cameron R
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1093/cid/ciy866" target="_blank" rel="noreferrer noopener">http://doi.org/10.1093/cid/ciy866</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
e1-e47
Issue
6
Volume
68
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Clinical Practice Guidelines by the Infectious Diseases Society of America: 2018 Update on Diagnosis, Treatment, Chemoprophylaxis, and Institutional Outbreak Management of Seasonal Influenzaa.
Publisher
An entity responsible for making the resource available
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
Date
A point or period of time associated with an event in the lifecycle of the resource
2019
2019-03
Subject
The topic of the resource
treatment; diagnostic testing; chemoprophylaxis; institutional outbreaks; seasonal influenza
Creator
An entity primarily responsible for making the resource
Uyeki Timothy M; Bernstein Henry H; Bradley John S; Englund Janet A; File Thomas M; Fry Alicia M; Gravenstein Stefan; Hayden Frederick G; Harper Scott A; Hirshon Jon Mark; Ison Michael G; Johnston B Lynn; Knight Shandra L; McGeer Allison; Riley Laura E; Wolfe Cameron R; Alexander Paul E; Pavia Andrew T
Description
An account of the resource
These clinical practice guidelines are an update of the guidelines published by the Infectious Diseases Society of America (IDSA) in 2009, prior to the 2009 H1N1 influenza pandemic. This document addresses new information regarding diagnostic testing, treatment and chemoprophylaxis with antiviral medications, and issues related to institutional outbreak management for seasonal influenza. It is intended for use by primary care clinicians, obstetricians, emergency medicine providers, hospitalists, laboratorians, and infectious disease specialists, as well as other clinicians managing patients with suspected or laboratory-confirmed influenza. The guidelines consider the care of children and adults, including special populations such as pregnant and postpartum women and immunocompromised patients.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1093/cid/ciy866" target="_blank" rel="noreferrer noopener">10.1093/cid/ciy866</a>
2019
Alexander Paul E
Bernstein Henry H
Bradley John S
Chemoprophylaxis
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
Department of Family & Community Medicine
Department of Internal Medicine
diagnostic testing
Englund Janet A
File Thomas M
Fry Alicia M
Gravenstein Stefan
Harper Scott A
Hayden Frederick G
Hirshon Jon Mark
institutional outbreaks
Ison Michael G
Johnston B Lynn
Knight Shandra L
McGeer Allison
NEOMED College of Medicine
Pavia Andrew T
Riley Laura E
seasonal influenza
Treatment
Uyeki Timothy M
Wolfe Cameron R
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.4254/wjh.v3.i9.228" target="_blank" rel="noreferrer noopener">http://doi.org/10.4254/wjh.v3.i9.228</a>
Pages
228–249
Issue
9
Volume
3
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Terpenoids as potential chemopreventive and therapeutic agents in liver cancer.
Publisher
An entity responsible for making the resource available
World journal of hepatology
Date
A point or period of time associated with an event in the lifecycle of the resource
2011
2011-09
Subject
The topic of the resource
Apoptosis; Chemoprevention; Treatment; Cell cycle; Hepatocarcinogenesis; Hepatocellular carcinoma; Liver cancer cells; Terpenoids
Creator
An entity primarily responsible for making the resource
Thoppil Roslin J; Bishayee Anupam
Description
An account of the resource
Despite significant advances in medicine, liver cancer, predominantly hepatocellular carcinoma remains a major cause of death in the United States as well as the rest of the world. As limited treatment options are currently available to patients with liver cancer, novel preventive control and effective therapeutic approaches are considered to be reasonable and decisive measures to combat this disease. Several naturally occurring dietary and non-dietary phytochemicals have shown enormous potential in the prevention and treatment of several cancers, especially those of the gastrointestinal tract. Terpenoids, the largest group of phytochemicals, traditionally used for medicinal purposes in India and China, are currently being explored as anticancer agents in clinical trials. Terpenoids (also called "isoprenoids") are secondary metabolites occurring in most organisms, particularly plants. More than 40 000 individual terpenoids are known to exist in nature with new compounds being discovered every year. A large number of terpenoids exhibit cytotoxicity against a variety of tumor cells and cancer preventive as well as anticancer efficacy in preclinical animal models. This review critically examines the potential role of naturally occurring terpenoids, from diverse origins, in the chemoprevention and treatment of liver tumors. Both in vitro and in vivo effects of these agents and related cellular and molecular mechanisms are highlighted. Potential challenges and future directions involved in the advancement of these promising natural compounds in the chemoprevention and therapy of human liver cancer are also discussed.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.4254/wjh.v3.i9.228" target="_blank" rel="noreferrer noopener">10.4254/wjh.v3.i9.228</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2011
Apoptosis
Bishayee Anupam
Cell cycle
Chemoprevention
Hepatocarcinogenesis
Hepatocellular carcinoma
Liver cancer cells
Terpenoids
Thoppil Roslin J
Treatment
World journal of hepatology
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.3171/2014.6.FOCUS14146" target="_blank" rel="noreferrer noopener">http://doi.org/10.3171/2014.6.FOCUS14146</a>
Pages
E9–E9
Issue
2
Volume
37
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
An institutional series and contemporary review of bacterial spinal epidural abscess: current status and future directions.
Publisher
An entity responsible for making the resource available
Neurosurgical focus
Date
A point or period of time associated with an event in the lifecycle of the resource
2014
2014-08
Subject
The topic of the resource
Female; Humans; Male; Middle Aged; Aged; Retrospective Studies; Treatment Outcome; Longitudinal Studies; treatment; ASIA = American Spinal Injury Association; Bacterial Infections/*complications/*epidemiology/therapy; CNS infection; Electronic Health Records/statistics & numerical data; Epidural Abscess/*complications/*epidemiology/therapy; management algorithm; MRSA = methicillin-resistant Staphylococcus aureus; SEA = spinal epidural abscess; spinal epidural abscess; spine surgery
Creator
An entity primarily responsible for making the resource
Shweikeh Faris; Saeed Kashif; Bukavina Laura; Zyck Stephanie; Drazin Doniel; Steinmetz Michael P
Description
An account of the resource
OBJECT: Over the past decade, the incidence of bacterial spinal epidural abscess (SEA) has been increasing. In recent years, studies on this condition have been rampant in the literature. The authors present an 11-year institutional experience with SEA patients. Additionally, through an analysis of the contemporary literature, they provide an update on the challenging and controversial nature of this increasingly encountered condition. METHODS: An electronic medical record database was used to retrospectively analyze patients admitted with SEA from January 2001 through February 2012. Presenting symptoms, concurrent conditions, microorganisms, diagnostic modalities, treatments, and outcomes were examined. For the literature search, PubMed was used as the search engine. Studies published from January 1, 2000, through December 31, 2013, were critically reviewed. Data from articles on methodology, demographics, treatments, and outcomes were recorded. RESULTS: A total of 106 patients with bacterial SEA were identified. The mean +/- SD age of patients was 63.3 +/- 13.7 years, and 65.1% of patients were male. Common presenting signs and symptoms were back pain (47.1%) and focal neurological deficits (47.1%). Over 75% of SEAs were in the thoracolumbar spine, and over 50% were ventral. Approximately 34% had an infectious origin. Concurrent conditions included diabetes mellitus (35.8%), vascular conditions (31.3%), and renal insufficiency/dialysis (30.2%). The most commonly isolated organism was Staphylococcus aureus (70.7%), followed by Streptococcus spp. (6.6%). Surgery along with antibiotics was the treatment for 63 (59.4%) patients. Surgery involved spinal fusion for 19 (30.2%), discectomy for 14 (22.2%), and corpectomy for 9 (14.3%). Outcomes were reported objectively; at a mean +/- SD follow-up time of 8.4 +/- 26 weeks (range 0-192 weeks), outcome was good for 60.7% of patients and poor for 39.3%. The literature search yielded 40 articles, and the authors discuss the result of these studies. CONCLUSIONS: Bacterial SEA is an ominous condition that calls for early recognition. Neurological status at the time of presentation is a key factor in decision making and patient outcome. In recent years, surgical treatment has been advocated for patients with neurological deficits and failed response to medical therapy. Surgery should be performed immediately and before 36-72 hours from onset of neurological sequelae. However, the decision between medical or surgical intervention entails individual patient considerations including age, concurrent conditions, and objective findings. An evidence-based algorithm for diagnosis and treatment is suggested.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.3171/2014.6.FOCUS14146" target="_blank" rel="noreferrer noopener">10.3171/2014.6.FOCUS14146</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2014
Aged
ASIA = American Spinal Injury Association
Bacterial Infections/*complications/*epidemiology/therapy
Bukavina Laura
CNS infection
Drazin Doniel
Electronic Health Records/statistics & numerical data
Epidural Abscess/*complications/*epidemiology/therapy
Female
Humans
Longitudinal Studies
Male
management algorithm
Middle Aged
MRSA = methicillin-resistant Staphylococcus aureus
Neurosurgical focus
Retrospective Studies
Saeed Kashif
SEA = spinal epidural abscess
Shweikeh Faris
spinal epidural abscess
spine surgery
Steinmetz Michael P
Treatment
Treatment Outcome
Zyck Stephanie
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1097/IPC.0000000000000350" target="_blank" rel="noreferrer noopener">http://doi.org/10.1097/IPC.0000000000000350</a>
Pages
3–10
Issue
1
Volume
24
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Diagnosis and Treatment of Clostridium difficile Infection (CDI).
Publisher
An entity responsible for making the resource available
Infectious diseases in clinical practice (Baltimore, Md.)
Date
A point or period of time associated with an event in the lifecycle of the resource
2016
2016-01
Subject
The topic of the resource
CDI; Clostridium difficile; diagnostic test; treatment
Creator
An entity primarily responsible for making the resource
Gerding Dale N; File Thomas M Jr; McDonald L Clifford
Description
An account of the resource
Early and accurate diagnosis is essential for optimal treatment of individuals with Clostridium difficile infection (CDI) and for implementation of effective infection control procedures. The decision about which diagnostic test to use is an important one that should be based on test sensitivity, specificity, and predictive value. The challenges of CDI go beyond rapid identification and management of symptomatic patients. Asymptomatic carriage has long been suspected in C. difficile transmission, but it may play a larger role than previously thought. Emerging information also shows that patients treated for CDI remain colonized for many weeks after symptom resolution. In fact, stool culture positivity increases during the first weeks following treatment completion. Treatments that reduce the duration and degree of asymptomatic shedding could have added benefit for reduced transmission.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1097/IPC.0000000000000350" target="_blank" rel="noreferrer noopener">10.1097/IPC.0000000000000350</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2016
CDI
Clostridium difficile
Department of Internal Medicine
diagnostic test
File Thomas M Jr
Gerding Dale N
Infectious diseases in clinical practice (Baltimore, Md.)
McDonald L Clifford
NEOMED College of Medicine
Treatment
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1093/schbul/sbv111" target="_blank" rel="noreferrer noopener">http://doi.org/10.1093/schbul/sbv111</a>
Pages
19–33
Issue
1
Volume
42
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Report on ISCTM Consensus Meeting on Clinical Assessment of Response to Treatment of Cognitive Impairment in Schizophrenia.
Publisher
An entity responsible for making the resource available
Schizophrenia bulletin
Date
A point or period of time associated with an event in the lifecycle of the resource
2016
2016-01
Subject
The topic of the resource
*Schizophrenic Psychology; Antipsychotic Agents/*therapeutic use; Cognition Disorders; Cognition Disorders/diagnosis/psychology/*therapy; cognitive assessment; Functional Assessment; Humans; Interviews; Neuropsychological Tests; neuropsychology; Nootropic Agents/*therapeutic use; Patient Selection; Psychiatric Rehabilitation/*methods; Research Instruments; Schizophrenia; Schizophrenia – Drug Therapy; Schizophrenia/diagnosis/*therapy; Severity of Illness Index; Surveys; treatment; United States Food and Drug Administration
Creator
An entity primarily responsible for making the resource
Keefe Richard S E; Haig George M; Marder Stephen R; Harvey Philip D; Dunayevich Eduardo; Medalia Alice; Davidson Michael; Lombardo Ilise; Bowie Christopher R; Buchanan Robert W; Bugarski-Kirola Dragana; Carpenter William T; Csernansky John T; Dago Pedro L; Durand Dante M; Frese Frederick J; Goff Donald C; Gold James M; Hooker Christine I; Kopelowicz Alex; Loebel Antony; McGurk Susan R; Opler Lewis A; Pinkham Amy E; Stern Robert G
Description
An account of the resource
If treatments for cognitive impairment are to be utilized successfully, clinicians must be able to determine whether they are effective and which patients should receive them. In order to develop consensus on these issues, the International Society for CNS Clinical Trials and Methodology (ISCTM) held a meeting of experts on March 20, 2014, in Washington, DC. Consensus was reached on several important issues. Cognitive impairment and functional disability were viewed as equally important treatment targets. The group supported the notion that sufficient data are not available to exclude patients from available treatments on the basis of age, severity of cognitive impairment, severity of positive symptoms, or the potential to benefit functionally from treatment. The group reached consensus that cognitive remediation is likely to provide substantial benefits in combination with procognitive medications, although a substantial minority believed that medications can be administered without nonpharmacological therapy. There was little consensus on the best methods for assessing cognitive change in clinical practice. Some participants supported the view that performance-based measures are essential for measurement of cognitive change; others pointed to their cost and time requirements as evidence of impracticality. Interview-based measures of cognitive and functional change were viewed as more practical, but lacking validity without informant involvement or frequent contact from clinicians. The lack of consensus on assessment methods was viewed as attributable to differences in experience and education among key stakeholders and significant gaps in available empirical data. Research on the reliability, validity, sensitivity, and practicality of competing methods will facilitate consensus.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1093/schbul/sbv111" target="_blank" rel="noreferrer noopener">10.1093/schbul/sbv111</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Schizophrenic Psychology
2016
Antipsychotic Agents/*therapeutic use
Bowie Christopher R
Buchanan Robert W
Bugarski-Kirola Dragana
Carpenter William T
Cognition Disorders
Cognition Disorders/diagnosis/psychology/*therapy
cognitive assessment
Csernansky John T
Dago Pedro L
Davidson Michael
Dunayevich Eduardo
Durand Dante M
Frese Frederick J
Functional Assessment
Goff Donald C
Gold James M
Haig George M
Harvey Philip D
Hooker Christine I
Humans
interviews
Keefe Richard S E
Kopelowicz Alex
Loebel Antony
Lombardo Ilise
Marder Stephen R
McGurk Susan R
Medalia Alice
Neuropsychological Tests
neuropsychology
Nootropic Agents/*therapeutic use
Opler Lewis A
Patient Selection
Pinkham Amy E
Psychiatric Rehabilitation/*methods
Research Instruments
Schizophrenia
Schizophrenia – Drug Therapy
Schizophrenia bulletin
Schizophrenia/diagnosis/*therapy
Severity of Illness Index
Stern Robert G
Surveys
Treatment
United States Food and Drug Administration
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1080/10408398.2014.982243" target="_blank" rel="noreferrer noopener">http://doi.org/10.1080/10408398.2014.982243</a>
Pages
1753–1775
Issue
10
Volume
56
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Potential Benefits of Edible Berries in the Management of Aerodigestive and Gastrointestinal Tract Cancers: Preclinical and Clinical Evidence.
Publisher
An entity responsible for making the resource available
Critical reviews in food science and nutrition
Date
A point or period of time associated with an event in the lifecycle of the resource
2016
2016-07
Subject
The topic of the resource
aerodigestive and gastrointestinal tract; Animal; Animal Studies; Animals; Anthocyanins/analysis/pharmacology; Anticarcinogenic Agents/*analysis/pharmacology; Antineoplastic Agents – Analysis; Antineoplastic Agents – Pharmacodynamics; Benzopyrans – Analysis; Benzopyrans – Pharmacodynamics; Berry; Biological; cancer; chemoprevention; Clinical Trials; Clinical Trials as Topic; Digestion – Drug Effects; Digestion/drug effects; Disease Models; Ellagic Acid/analysis/pharmacology; Fruit; Fruit/*chemistry; Gastrointestinal Neoplasms – Prevention and Control; Gastrointestinal Neoplasms/*prevention & control; Human; Humans; Models; Phytochemicals – Analysis; Phytochemicals – Pharmacodynamics; Phytochemicals/analysis/pharmacology; Plant Extracts – Analysis; Plant Extracts – Pharmacodynamics; Plant Extracts/*analysis/pharmacology; Polyphenols – Analysis; Polyphenols – Pharmacodynamics; Polyphenols/analysis/pharmacology; treatment
Creator
An entity primarily responsible for making the resource
Bishayee Anupam; Haskell Yennie; Do Chau; Siveen Kodappully Sivaraman; Mohandas Nima; Sethi Gautam; Stoner Gary D
Description
An account of the resource
Epidemiological reports as well as experimental studies have demonstrated the significant health benefits provided by regular berry consumption. Berries possess both prophylactic and therapeutic potential against several chronic illnesses, such as cardiovascular, neurodegenerative, and neoplastic diseases. Berries owe their health benefits to phytoconstituents, such as polyphenolic anthocyanins, ellagic acid, and a diverse array of phytochemicals bestowed with potent antioxidant and anti-inflammatory effects as well as the ability to engage a multitude of signaling pathways. This review highlights the principal chemical constituents present in berries and their primary molecular targets. The article presents and critically analyzes the chemopreventive and therapeutic potential of berry extracts, fractions, and bioactive components on various cancers of the gastrointestinal tract (GIT), including esophageal, stomach, intestinal, and colorectal cancers as well as cancers of the upper aerodigestive tract, such as oral cancer. The current status of clinical studies evaluating berry products in several aforementioned cancers is presented. Various emerging issues including dose-ranging and dosage forms, the role of synergy and the usage of combination therapy as well as other relevant areas essential for the development of berry phytoconstituents as mainstream chemopreventive and therapeutic agents against aerodigestive and GIT cancers are critically discussed.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1080/10408398.2014.982243" target="_blank" rel="noreferrer noopener">10.1080/10408398.2014.982243</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2016
aerodigestive and gastrointestinal tract
Animal
Animal Studies
Animals
Anthocyanins/analysis/pharmacology
Anticarcinogenic Agents/*analysis/pharmacology
Antineoplastic Agents – Analysis
Antineoplastic Agents – Pharmacodynamics
Benzopyrans – Analysis
Benzopyrans – Pharmacodynamics
Berry
Biological
Bishayee Anupam
Cancer
Chemoprevention
Clinical Trials
Clinical Trials as Topic
Critical reviews in food science and nutrition
Digestion – Drug Effects
Digestion/drug effects
Disease Models
Do Chau
Ellagic Acid/analysis/pharmacology
Fruit
Fruit/*chemistry
Gastrointestinal Neoplasms – Prevention and Control
Gastrointestinal Neoplasms/*prevention & control
Haskell Yennie
Human
Humans
Models
Mohandas Nima
Phytochemicals – Analysis
Phytochemicals – Pharmacodynamics
Phytochemicals/analysis/pharmacology
Plant Extracts – Analysis
Plant Extracts – Pharmacodynamics
Plant Extracts/*analysis/pharmacology
Polyphenols – Analysis
Polyphenols – Pharmacodynamics
Polyphenols/analysis/pharmacology
Sethi Gautam
Siveen Kodappully Sivaraman
Stoner Gary D
Treatment
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/s0190-9622(97)80322-2" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/s0190-9622(97)80322-2</a>
Pages
705–710
Issue
5
Volume
36
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Oral contraceptive failure rates and oral antibiotics.
Publisher
An entity responsible for making the resource available
Journal of the American Academy of Dermatology
Date
A point or period of time associated with an event in the lifecycle of the resource
1997
1997-05
Subject
The topic of the resource
*Antibiotics; *Case Control Studies; *Contraception Failure; *Contraceptives; *Drug Interactions; *Oral Contraceptives–side effects; *Pregnancy; *Research Report; Administration; Adolescent; Adult; Americas; Anti-Bacterial Agents/*administration & dosage/adverse effects; Combined; Contraception; Contraceptive Methods–side effects; Contraceptive Usage; Dermatology; Developed Countries; Drug Interactions; Drugs; Family Planning; Female; Humans; North America; Northern America; Oral; Research Methodology; Retrospective Studies; Studies; Treatment; United States
Creator
An entity primarily responsible for making the resource
Helms S E; Bredle D L; Zajic J; Jarjoura D; Brodell R T; KrishnaRao I
Description
An account of the resource
BACKGROUND: Despite anecdotal evidence of a possibility of decreased effectiveness of oral contraceptives (OCs) with some antibiotics, it is not known whether antibiotic use in dermatologic practices engenders any increased risk of accidental pregnancy. OBJECTIVE: Our purpose was to examine the effect of commonly prescribed oral antibiotics (tetracyclines, penicillins, cephalosporins) on the failure rate of OCs. METHODS: The records from three dermatology practices were reviewed, and 356 patients with a history of combined oral antibiotic/OC use were surveyed retrospectively. Of these patients, 263 also provided "control" data (during the times they used OCs alone). An additional 162 patients provided control data only. RESULTS: Five pregnancies occurred in 311 woman-years of combined antibiotic/OC exposure (1.6% per year failure rate) compared with 12 pregnancies in 1245 woman-years of exposure (0.96% per year) for the 425 control patients. This difference was not significant (p = 0.4), and the 95% confidence interval on the difference (-0.81, 2.1) ruled out a substantial difference (\textgreater 2.1% per year). There was also no significant difference between OC failure rates for the women who provided data under both conditions, nor between the two control groups. All our data groups had failure rates below the 3% or higher per year, which are typically found in the United States. CONCLUSION: The difference in failure rates of OCs when taken concurrently with antibiotics commonly used in dermatology versus OC use alone suggests that these antibiotics do not increase the risk of pregnancy. Physicians and patients need to recognize that the expected OC failure rate, regardless of antibiotic use, is at least 1% per year and it is not yet possible to predict in whom OCs may fail.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/s0190-9622(97)80322-2" target="_blank" rel="noreferrer noopener">10.1016/s0190-9622(97)80322-2</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Antibiotics
*Case Control Studies
*Contraception Failure
*Contraceptives
*Drug Interactions
*Oral Contraceptives–side effects
*Pregnancy
*Research Report
1997
Administration
Adolescent
Adult
Americas
Anti-Bacterial Agents/*administration & dosage/adverse effects
Bredle D L
Brodell R T
Combined
Contraception
Contraceptive Methods–side effects
Contraceptive Usage
Dermatology
Developed Countries
Drug Interactions
Drugs
Family Planning
Female
Helms S E
Humans
Jarjoura D
Journal of the American Academy of Dermatology
KrishnaRao I
North America
Northern America
Oral
Research Methodology
Retrospective Studies
Studies
Treatment
United States
Zajic J
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.jsat.2017.12.009" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.jsat.2017.12.009</a>
Pages
45–51
Volume
86
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Patterns of co-occurring addictions, posttraumatic stress disorder, and major depressive disorder in detoxification treatment seekers: Implications for improving detoxification treatment outcomes.
Publisher
An entity responsible for making the resource available
Journal of substance abuse treatment
Date
A point or period of time associated with an event in the lifecycle of the resource
2018
2018-03
Subject
The topic of the resource
Detoxification; Latent class analysis; Polysubstance use; PTSD; Treatment
Creator
An entity primarily responsible for making the resource
Anderson RaeAnn E; Hruska Bryce; Boros Alec P; Richardson Christopher J; Delahanty Douglas L
Description
An account of the resource
BACKGROUND AND OBJECTIVES: Poly-substance use and psychiatric comorbidity are common among individuals receiving substance detoxification services. Posttraumatic stress disorder (PTSD) and major depressive disorder (MDD) are the most common co-occurring psychiatric disorders with substance use disorder (SUD). Current treatment favors a one-size-fits-all approach to treating addiction focusing on one substance or one comorbidity. Research examining patterns of substance use and comorbidities can inform efforts to effectively identify and differentially treat individuals with co-occurring conditions. METHODS: Using latent class analysis, the current study identified four patterns of PTSD, MDD, and substance use among 375 addiction treatment seekers receiving medically supervised detoxification. RESULTS: The four identified classes were: 1) a
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/j.jsat.2017.12.009" target="_blank" rel="noreferrer noopener">10.1016/j.jsat.2017.12.009</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2018
Anderson RaeAnn E
Boros Alec P
Delahanty Douglas L
Detoxification
Hruska Bryce
Journal of substance abuse treatment
Latent class analysis
Polysubstance use
PTSD
Richardson Christopher J
Treatment
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1007/s11101-014-9337-5" target="_blank" rel="noreferrer noopener">http://doi.org/10.1007/s11101-014-9337-5</a>
Pages
793–810
Issue
4
Volume
13
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Oleanane triterpenoids in the prevention and therapy of breast cancer: current evidence and future perspectives.
Publisher
An entity responsible for making the resource available
Phytochemistry reviews : proceedings of the Phytochemical Society of Europe
Date
A point or period of time associated with an event in the lifecycle of the resource
2014
2014-12
Subject
The topic of the resource
Chemoprevention; Mammary cancer; Oleanolic acid; Synthetic oleananes; Treatment
Creator
An entity primarily responsible for making the resource
Parikh Nisha R; Mandal Animesh; Bhatia Deepak; Siveen Kodappully Sivaraman; Sethi Gautam; Bishayee Anupam
Description
An account of the resource
Breast cancer is one of the most frequently diagnosed cancers and major cause of death in women in the world. Emerging evidence underscores the value of dietary and non-dietary phytochemicals, including triterpenoids, in the prevention and treatment of breast cancer. Oleanolic acid, an oleanane-type pentacyclic triterpenoid, is present in a large number of dietary and medicinal plants. Oleanolic acid and its derivatives exhibit several promising pharmacological activities, including antioxidant, anti-inflammatory, hepatoprotective, cardioprotective, antipruritic, spasmolytic, antiallergic, antimicrobial and antiviral effects. Numerous studies indicate that oleanolic acid and other oleanane triterpenoids modulate multiple intracellular signaling pathways and exert chemopreventive and antitumor activities in various in vitro and in vivo model systems. A series of novel synthetic oleanane triterpenoids have been prepared by chemical modifications of oleanolic acid and some of these compounds are considered to be the most potent anti-inflammatory and anticarcinogenic triterpenoids. Accumulating studies provide extensive evidence that synthetic oleanane derivatives inhibit proliferation and induce apoptosis of various cancer cells in vitro and demonstrate cancer preventive or antitumor efficacy in animal models of blood, breast, colon, connective tissue, liver, lung, pancreas, prostate and skin cancer. This review critically examines the potential role of oleanolic acid, oleanane triterpenoids and related synthetic compounds in the chemoprevention and treatment of mammary neoplasia. Both in vitro and in vivo studies on these agents and related molecular mechanisms are presented. Several challenges and future directions of research to translate already available impressive preclinical knowledge to clinical practice of breast cancer prevention and therapy are also presented.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1007/s11101-014-9337-5" target="_blank" rel="noreferrer noopener">10.1007/s11101-014-9337-5</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2014
Bhatia Deepak
Bishayee Anupam
Chemoprevention
Mammary cancer
Mandal Animesh
Oleanolic acid
Parikh Nisha R
Phytochemistry reviews : proceedings of the Phytochemical Society of Europe
Sethi Gautam
Siveen Kodappully Sivaraman
Synthetic oleananes
Treatment