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40
2
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Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1194/jlr.M015859" target="_blank" rel="noreferrer noopener">http://doi.org/10.1194/jlr.M015859</a>
Pages
1561–1568
Issue
8
Volume
52
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Aldo-keto reductase 1B7 is a target gene of FXR and regulates lipid and glucose homeostasis.
Publisher
An entity responsible for making the resource available
Journal of lipid research
Date
A point or period of time associated with an event in the lifecycle of the resource
2011
2011-08
Subject
The topic of the resource
*Aldehyde Reductase/genetics/metabolism; Adenoviridae; Animal; Animals; Blood Glucose/*metabolism; Cholesterol/analysis; Cytoplasmic and Nuclear/genetics/*metabolism; Diabetes Mellitus/genetics/*metabolism/physiopathology; Disease Models; Fatty Liver/genetics/*metabolism/physiopathology; Gene Expression; Genetic Vectors; Gluconeogenesis/genetics; Homeostasis; Humans; Liver/*metabolism/physiopathology; Malondialdehyde/blood; Mice; Polymerase Chain Reaction; Receptors; Transfection; Transgenic; Triglycerides/analysis
Creator
An entity primarily responsible for making the resource
Ge Xuemei; Yin Liya; Ma Huiyan; Li Tiangang; Chiang John Y L; Zhang Yanqiao
Description
An account of the resource
Aldo-keto reductase 1B7 (AKR1B7) is proposed to play a role in detoxification of by-products of lipid peroxidation. In this article, we show that activation of the nuclear receptor farnesoid X receptor (FXR) induces AKR1B7 expression in the liver and intestine, and reduces the levels of malondialdehyde (MDA), the end product of lipid peroxidation, in the intestine but not in the liver. To determine whether AKR1B7 regulates MDA levels in vivo, we overexpressed AKR1B7 in the liver. Overexpression of AKR1B7 in the liver had no effect on hepatic or plasma MDA levels. Interestingly, hepatic expression of AKR1B7 significantly lowered plasma glucose levels in both wild-type and diabetic db/db mice, which was associated with reduced hepatic gluconeogenesis. Hepatic expression of AKR1B7 also significantly lowered hepatic triglyceride and cholesterol levels in db/db mice. These data reveal a novel function for AKR1B7 in lipid and glucose metabolism and suggest that AKR1B7 may not play a role in detoxification of lipid peroxides in the liver. AKR1B7 may be a therapeutic target for treatment of fatty liver disease associated with diabetes mellitus.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1194/jlr.M015859" target="_blank" rel="noreferrer noopener">10.1194/jlr.M015859</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Aldehyde Reductase/genetics/metabolism
2011
Adenoviridae
Animal
Animals
Blood Glucose/*metabolism
Chiang John Y L
Cholesterol/analysis
Cytoplasmic and Nuclear/genetics/*metabolism
Department of Integrative Medical Sciences
Diabetes Mellitus/genetics/*metabolism/physiopathology
Disease Models
Fatty Liver/genetics/*metabolism/physiopathology
Ge Xuemei
Gene Expression
Genetic Vectors
Gluconeogenesis/genetics
Homeostasis
Humans
Journal of lipid research
Li Tiangang
Liver/*metabolism/physiopathology
Ma Huiyan
Malondialdehyde/blood
Mice
NEOMED College of Medicine
Polymerase Chain Reaction
Receptors
Transfection
Transgenic
Triglycerides/analysis
Yin Liya
Zhang Yanqiao
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.ejmech.2017.02.037" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.ejmech.2017.02.037</a>
Pages
303–309
Volume
129
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Synthesis and biological evaluations of chalcones, flavones and chromenes as farnesoid x receptor (FXR) antagonists.
Publisher
An entity responsible for making the resource available
European journal of medicinal chemistry
Date
A point or period of time associated with an event in the lifecycle of the resource
2017
2017-03
Subject
The topic of the resource
Animals; Antagonist; Benzopyrans/chemical synthesis/*pharmacology; Chalcones; Chalcones/chemical synthesis/*pharmacology; Chromenes; Cytoplasmic and Nuclear/*antagonists & inhibitors; Farnesoid X receptor; Flavones/chemical synthesis/*pharmacology; Liver Diseases/drug therapy; Liver/chemistry/*drug effects/metabolism; Mice; Receptors; Triglycerides/analysis
Creator
An entity primarily responsible for making the resource
Zhang Guoning; Liu Shuainan; Tan Wenjuan; Verma Ruchi; Chen Yuan; Sun Deyang; Huan Yi; Jiang Qian; Wang Xing; Wang Na; Xu Yang; Wong Chiwai; Shen Zhufang; Deng Ruitang; Liu Jinsong; Zhang Yanqiao; Fang Weishuo
Description
An account of the resource
Farnesoid X receptor (FXR), a nuclear receptor mainly distributed in liver and intestine, has been regarded as a potential target for the treatment of various metabolic diseases, cancer and infectious diseases related to liver. Starting from two previously identified chalcone-based FXR antagonists, we tried to increase the activity through the design and synthesis of a library containing chalcones, flavones and chromenes, based on substitution manipulation and conformation (ring closure) restriction strategy. Many chalcones and four chromenes were identified as microM potent FXR antagonists, among which chromene 11c significantly decreased the plasma and hepatic triglyceride level in KKay mice.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/j.ejmech.2017.02.037" target="_blank" rel="noreferrer noopener">10.1016/j.ejmech.2017.02.037</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2017
Animals
Antagonist
Benzopyrans/chemical synthesis/*pharmacology
Chalcones
Chalcones/chemical synthesis/*pharmacology
Chen Yuan
Chromenes
Cytoplasmic and Nuclear/*antagonists & inhibitors
Deng Ruitang
European journal of medicinal chemistry
Fang Weishuo
Farnesoid X receptor
Flavones/chemical synthesis/*pharmacology
Huan Yi
Jiang Qian
Liu Jinsong
Liu Shuainan
Liver Diseases/drug therapy
Liver/chemistry/*drug effects/metabolism
Mice
Receptors
Shen Zhufang
Sun Deyang
Tan Wenjuan
Triglycerides/analysis
Verma Ruchi
Wang Na
Wang Xing
Wong Chiwai
Xu Yang
Zhang Guoning
Zhang Yanqiao