1 40 1 Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. URL Address <a href="http://doi.org/10.1002/ardp.201500293" target="_blank" rel="noreferrer noopener">http://doi.org/10.1002/ardp.201500293</a> Pages 252–267 Issue 4 Volume 349 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Synthesis and Biological Evaluation of Pentacycloundecylamines and Triquinylamines as Voltage-Gated Calcium Channel Blockers. Publisher An entity responsible for making the resource available Archiv der Pharmazie Date A point or period of time associated with an event in the lifecycle of the resource 2016 2016-04 Subject The topic of the resource Alicyclic/chemical synthesis/*chemistry/pharmacology; Amines/chemical synthesis/*chemistry/pharmacology; Animals; Apoptosis/drug effects; Calcium Channel Blockers/chemical synthesis/*chemistry/pharmacology; Calcium Channels; Calcium/*metabolism; Cell Survival/drug effects; Hydrocarbons; Hydrogen Peroxide/pharmacology; L-Lactate Dehydrogenase/metabolism; L-type calcium channel (LTCC) blockers; L-Type/*metabolism; Multifunctional drugs; Neurodegeneration; PC12 Cells; Pentacycloundecylamine; Quinones/chemical synthesis/*chemistry/pharmacology; Rats; Structure-Activity Relationship; Triquinylamine Creator An entity primarily responsible for making the resource Young Lois-May; Geldenhuys Werner J; Domingo Olwen C; Malan Sarel F; Van der Schyf Cornelis J Description An account of the resource Preclinical studies for neurodegenerative diseases have shown a multi-targeted approach to be successful in the treatment of these complex disorders with several pathoetiological pathways. Polycyclic compounds, such as NGP1-01 (7a), have demonstrated the ability to target multiple mechanisms of the complex etiology and are referred to as multifunctional compounds. These compounds have served as scaffolds with the ability to attenuate Ca(2+) overload and excitotoxicity through several pathways. In this study, our focus was on mitigating Ca(2+) overload through the L-type calcium channels (LTCC). Here, we report the synthesis and biological evaluation of several novel polycyclic compounds. We determined the IC50 values for both the pentacycloundecylamines and the triquinylamines by means of a high-throughput fluorescence calcium flux assay utilizing Fura-2/AM. The potential of these compounds to offer protection against hydrogen peroxide-induced cell death was also evaluated. Overall, Identifier An unambiguous reference to the resource within a given context <a href="http://doi.org/10.1002/ardp.201500293" target="_blank" rel="noreferrer noopener">10.1002/ardp.201500293</a> Rights Information about rights held in and over the resource Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s). 2016 Alicyclic/chemical synthesis/*chemistry/pharmacology Amines/chemical synthesis/*chemistry/pharmacology Animals Apoptosis/drug effects Archiv der Pharmazie Calcium Channel Blockers/chemical synthesis/*chemistry/pharmacology Calcium Channels Calcium/*metabolism Cell Survival/drug effects Domingo Olwen C Geldenhuys Werner J Hydrocarbons Hydrogen Peroxide/pharmacology L-Lactate Dehydrogenase/metabolism L-type calcium channel (LTCC) blockers L-Type/*metabolism Malan Sarel F Multifunctional drugs Neurodegeneration PC12 Cells Pentacycloundecylamine Quinones/chemical synthesis/*chemistry/pharmacology Rats Structure-Activity Relationship Triquinylamine Van der Schyf Cornelis J Young Lois-May