RELATIONSHIP OF ACETALDEHYDE ELEVATION TO FACIAL FLUSHING AND INTOXICATION IN ORIENTAL AND OCCIDENTAL SUBJECTS
Substance Abuse
Truitt E B; Rowe C S; Mehl D
Alcoholism-Clinical and Experimental Research
1984
1984
Journal Article
n/a
ASPIRIN ALTERATION OF ALCOHOL-INDUCED FACIAL FLUSHING AND INTOXICATION IN ORIENTAL AND OCCIDENTAL SUBJECTS
Substance Abuse
Truitt E B; Rowe C S; Mehl D
Alcoholism-Clinical and Experimental Research
1985
1985
Journal Article
n/a
ACETALDEHYDE (ACH) DETERMINATION - A NOVEL HPLC METHOD FOR BLOOD AND TISSUE ACH WITH INCREASED SENSITIVITY AND PREVENTION OF ARTIFACTUAL FORMATION OF ACH FROM ETHANOL
Substance Abuse
Truitt E B; Rowe C S
Alcoholism-Clinical and Experimental Research
1983
1983
Journal Article
n/a
EFFECT OF CHRONIC ETHANOL ON AMPHETAMINE-INDUCED AND APOMORPHINE-INDUCED STEREOTYPICAL BEHAVIOR AND ITS ATTENUATION BY LITHIUM
Substance Abuse
Truitt E B; Kirschner E; McGinley P A
Alcoholism-Clinical and Experimental Research
1980
1980
Journal Article
n/a
ASPIRIN ALTERATION OF ALCOHOL-INDUCED FACIAL FLUSHING AND INTOXICATION .2. NON-FLUSHING OCCIDENTAL SUBJECTS
Substance Abuse
Truitt E B; Gaynor C R
Alcohol and Alcoholism
1986
1986
Journal Article
n/a
HYPNOTIC AND LETHAL INTERACTIONS BETWEEN LITHIUM AND ETHANOL
Life Sciences & Biomedicine - Other Topics
Truitt E B
Federation Proceedings
1978
1978
Journal Article
n/a
EFFECTS OF A SINGLE IV GLUCOCORTICOID DOSE ON BIOGENIC-AMINE LEVELS IN CAT SPINAL-CORD
Life Sciences & Biomedicine - Other Topics
McGinley P A; Truitt E B; Hall E D
Federation Proceedings
1981
1981
Journal Article or Conference Abstract Publication
n/a
Aspirin Reversal Of The Disulfiram-ethanol Reaction In Man - A Case-study
Substance Abuse
Liepman M R; Wartenberg A A; Swift R M; Nirenberg T D; Truitt E B
Alcoholism-Clinical and Experimental Research
1988
1988-04
Journal Article or Conference Abstract Publication
n/a
Hemoglobin-acetaldehyde Adduct Tests - Relationship In Alcoholic Patients To Liver-function
Substance Abuse
Liebelt R A; Hazelett S E; Truitt E B
Journal of Addictive Diseases
1995
1995
Journal Article or Conference Abstract Publication
n/a
Improved Separation Of Acetaldehyde-induced Hemoglobin
acetaldehyde; adducts; alcoholism; biological marker; chromatography (hplc); hemoglobin; high-pressure liquid; liquid-chromatography; Substance Abuse
A fast-eluting minor variant of hemoglobin A, designated as HbA1-AcH, appears elevated after the incubation of red blood cell hemolysates with acetaldehyde (AcH) and has been proposed as a diagnostic marker for alcoholism or as an indicator for heavy drinking. We have developed an improved HPLC separation of this peak and others elevated by AcH using a polyaspartic acid column (PolyCAT A, PolyLC, Inc.) and a nonlinear buffer gradient with pH changes from 6.6 to 6.8. Saline-washed red blood cells were treated with sodium acetate buffer (pH 5.5) to remove unstable Schiff bases, and then hemolyzed by addition of an equal volume of H2O and 0.4 volumes of CCl4. HbA1-AcH and several others, including two peaks in the HbA1a+b cluster, Hb Pre-A1c, and HbA1d3 were significantly increased by AcH incubation, and the changes were only partially reversible with time. Improved resolution of these peaks allows more accurate quantitation of AcH adducts of hemoglobin.
Hazelett S E; Liebelt R A; Truitt E B
Alcoholism-Clinical and Experimental Research
1993
1993-10
Journal Article or Conference Abstract Publication
<a href="http://doi.org/10.1111/j.1530-0277.1993.tb05672.x" target="_blank" rel="noreferrer noopener">10.1111/j.1530-0277.1993.tb05672.x</a>
Evaluation Of Acetaldehyde-modified Hemoglobin And Other Markers Of Chronic Heavy Alcohol Use: Effects Of Gender And Hemoglobin Concentration
abuse; acetaldehyde; adducts; alcohol; carbohydrate-deficient transferrin; cation-exchange chromatography; consumption; drinking; gamma-glutamyl-transferase; gender; hemoglobin; HPLC; liquid-chromatography; liver-disease; serum; Substance Abuse
The present study examined whether measurement of hemoglobin-acetaldehyde (HbA1-AcH) using an improved methodology may be useful as a biological marker of alcohol abuse. Red blood cell hemolysates of 182 patients consecutively admitted to the drug and alcohol treatment unit of our institution were analyzed for HbA1-AcH concentration using cation exchange HPLC. Mean HbA1-AcH of those who claimed to drink greater than or equal to 6 drinks/day [mean = 0.055 (% total hemoglobin), SD = 0.051] was significantly higher than the mean of those who drank <6 drinks/day (mean = 0.026, SD = 0.0174). The greatest sum of sensitivity (67%) and specificity (77%) came with a cut-score of 0.030 area% of total hemoglobin. A cut-score of 0.080 produced a 100% specificity, but lowered the sensitivity to 20%. The Pearson product moment correlation (r) between HbA1-AcH and reported drinks per day was r = 0.30 (p < 0.001). There was no significant difference in the association of HbA1-AcH end reported drinking between males and females, and the small difference observed was shown to be entirely associated with differences in hemoglobin levels between the sexes. Cocaine use did not significantly alter the correlation between reported drinking and HbA1-AcH levels. Hemoglobin levels were shown to have a significant correlation with HbA1-AcH independent of drinking. HbA1-AcH was shown to have a better sensitivity and specificity than gamma-glutamyltransferase, ALT, AST, or mean corpuscular volume in this population. The results suggest that HbA1-AcH may be a useful marker to help detect alcohol abuse, especially in populations where other markers have been shown to fail.
Hazelett S E; Liebelt R A; Brown W J; Androulakakis V; Jarjoura D; Truitt E B
Alcoholism-Clinical and Experimental Research
1998
1998-11
Journal Article or Conference Abstract Publication
<a href="http://doi.org/10.1097/00000374-199811000-00029" target="_blank" rel="noreferrer noopener">10.1097/00000374-199811000-00029</a>
ACUTE LOW-LEVEL FORMALDEHYDE BEHAVIORAL AND NEUROCHEMICAL TOXICITY IN THE RAT
Psychiatry; Neurosciences & Neurology; Pharmacology & Pharmacy
Boja J W; Nielsen J A; Foldvary E; Truitt E B
Progress in Neuro-Psychopharmacology & Biological Psychiatry
1985
1985
Journal Article or Conference Abstract Publication
<a href="http://doi.org/10.1016/0278-5846(85)90038-7" target="_blank" rel="noreferrer noopener">10.1016/0278-5846(85)90038-7</a>