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Text
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URL Address
<a href="http://doi.org/10.18632/oncotarget.4430" target="_blank" rel="noreferrer noopener">http://doi.org/10.18632/oncotarget.4430</a>
Pages
16757–16765
Issue
18
Volume
6
Dublin Core
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Title
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Six stroma-based RNA markers diagnostic for prostate cancer in European-Americans validated at the RNA and protein levels in patients in China.
Publisher
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Oncotarget
Date
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2015
2015-06
Subject
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diagnosis; Adult; Humans; prostate cancer; Male; Middle Aged; Aged; Young Adult; Gene Expression Profiling; Gene Expression Regulation; Tumor Microenvironment; Biomarkers; China; European Continental Ancestry Group/genetics; microenvironment; Prostate/pathology; Prostatic Neoplasms/*diagnosis/*genetics; race; stroma; 80 and over; Neoplastic; Tumor/*genetics
Creator
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Zhu Jian-Guo; Pan Cong; Jiang Jun; Deng Mingsen; Gao Hengjun; Men Bozhao; McClelland Michael; Mercola Dan; Zhong Wei-D; Jia Zhenyu
Description
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We previously analyzed human prostate tissue containing stroma near to tumor and from cancer-negative tissues of volunteers. Over 100 candidate gene expression differences were identified and used to develop a classifier that could detect nearby tumor with an accuracy of 97% (sensitivity = 98% and specificity = 88%) based on 364 independent test cases from primarily European American cases. These stroma-based gene signatures have the potential to identify cancer patients among those with negative biopsies. In this study, we used prostate tissues from Chinese cases to validate six of these markers (CAV1, COL4A2, HSPB1, ITGB3, MAP1A and MCAM). In validation by real-time PCR, four genes (COL4A2, HSPB1, ITGB3, and MAP1A) demonstrated significantly lower expression in tumor-adjacent stroma compared to normal stroma (p value
Identifier
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<a href="http://doi.org/10.18632/oncotarget.4430" target="_blank" rel="noreferrer noopener">10.18632/oncotarget.4430</a>
Rights
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2015
80 and over
Adult
Aged
Biomarkers
China
Deng Mingsen
Diagnosis
European Continental Ancestry Group/genetics
Gao Hengjun
Gene Expression Profiling
Gene Expression Regulation
Humans
Jia Zhenyu
Jiang Jun
Male
McClelland Michael
Men Bozhao
Mercola Dan
microenvironment
Middle Aged
Neoplastic
Oncotarget
Pan Cong
Prostate cancer
Prostate/pathology
Prostatic Neoplasms/*diagnosis/*genetics
Race
stroma
Tumor Microenvironment
Tumor/*genetics
Young Adult
Zhong Wei-D
Zhu Jian-Guo