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<a href="https://www.omicsonline.org/open-access/why-donrsquot-we-have-a-vaccine-against-autoimmune-diseases--a-review.pdf" target="_blank" rel="noreferrer noopener">http://doi.org/10.4172/2155-9899.1000574</a>
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Why Don't We Have a Vaccine Against Autoimmune Diseases? - A Review
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Journal of Clinical & Cellular Immunology
Date
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2019
2019
Subject
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Autoimmune; Immunotherapy; Multiple sclerosis; Rheumatoid arthritis; Type 1 diabetes; Vaccine
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Rosenthal Ken S; Carambula Roy; Zimmerman Daniel H
Description
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This review examines some of the reasons why we don't have a vaccine against autoimmune diseases and highlights the progress that has been made. Many autoimmune diseases, such as rheumatoid arthritis (RA), multiple sclerosis (MS) and type 1 diabetes (T1D), are driven by autoimmune T cell responses. Unlike vaccines for most infectious diseases, which elicit antibody responses, are intended for immuno-naive individuals and considered preventative, a vaccine for an autoimmune disease must be therapeutic and resolve or control the on-going autoimmune response and condition in the diseased host. Despite these differences, many of the same considerations for infectious disease vaccines must also be addressed to develop a therapeutic vaccine for autoimmune diseases. The disease initiator/triggers, antigens and autoantigens, nature of the immunopathogenic and protective/therapeutic immune response will be compared for infectious and autoimmune diseases as will approaches for developing vaccines including formulations, animal models and indicators of success. The rationale for a therapeutic vaccine for RA will be discussed in greater detail with a relatively limited discussion of T1D, MS and other autoimmune diseases.
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<a href="http://doi.org/10.4172/2155-9899.1000574" target="_blank" rel="noreferrer noopener">10.4172/2155-9899.1000574</a>
2019
Autoimmune
Carambula Roy
Department of Integrative Medical Sciences
immunotherapy
Journal of clinical & cellular immunology
Multiple sclerosis
NEOMED College of Medicine
Rheumatoid arthritis
Rosenthal Ken S
September 2019 Update
Type 1 diabetes
Vaccine
Zimmerman Daniel H