1
40
2
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Pages
213–220
Issue
1
Volume
71
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Inhibition of phosphorylation of TrkB and TrkC and their signal transduction by alpha2-macroglobulin.
Publisher
An entity responsible for making the resource available
Journal of neurochemistry
Date
A point or period of time associated with an event in the lifecycle of the resource
1998
1998-07
Subject
The topic of the resource
Humans; Animals; Mice; Signal Transduction/drug effects/*physiology; Phosphorylation; Mitogen-Activated Protein Kinase 1/metabolism; Antineoplastic Agents/pharmacology; Type C Phospholipases/metabolism; Cell Differentiation/drug effects; Neuroprotective Agents/*metabolism; Neuroblastoma; alpha-Macroglobulins/*pharmacology; *Mitogen-Activated Protein Kinases; 3T3 Cells/chemistry/cytology/enzymology; Brain-Derived Neurotrophic Factor/pharmacology; Calcium-Calmodulin-Dependent Protein Kinases/metabolism; Isoenzymes/metabolism; Mitogen-Activated Protein Kinase 3; Nerve Growth Factors/pharmacology; Neurotrophin 3; Phospholipase C gamma; Receptor Protein-Tyrosine Kinases/*metabolism; Serotonin/metabolism; Tretinoin/pharmacology; Ciliary Neurotrophic Factor; Receptors; Receptor; Tumor Cells; Cultured/chemistry/cytology/enzymology; Nerve Growth Factor/*metabolism; trkC
Creator
An entity primarily responsible for making the resource
Hu Y Q; Koo P H
Description
An account of the resource
Monoamine-activated alpha2-macroglobulin (alpha2M) was shown to reduce the dopamine concentration in corpus striatum of adult rat brains and inhibit other neuronal functions in vivo and in vitro. As brain-derived neurotrophic factor, neurotrophin-4, and neurotrophin-3 are important neurotrophic factors for dopaminergic neurons, the effect of monoamine-activated alpha2M on signal transduction by trkB and trkC was investigated. The results show that monoamine-activated alpha2M binds to trkB and inhibits brain-derived neurotrophic factor/neurotrophin-4-promoted autophosphorylation of trkB in a dose-dependent manner in both trkB-expressing NIH3T3 (NIH3T3-trkB) and human neuroblastoma
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Mitogen-Activated Protein Kinases
1998
3T3 Cells/chemistry/cytology/enzymology
alpha-Macroglobulins/*pharmacology
Animals
Antineoplastic Agents/pharmacology
Brain-Derived Neurotrophic Factor/pharmacology
Calcium-Calmodulin-Dependent Protein Kinases/metabolism
Cell Differentiation/drug effects
Ciliary Neurotrophic Factor
Cultured/chemistry/cytology/enzymology
Hu Y Q
Humans
Isoenzymes/metabolism
Journal of neurochemistry
Koo P H
Mice
Mitogen-Activated Protein Kinase 1/metabolism
Mitogen-Activated Protein Kinase 3
Nerve Growth Factor/*metabolism
Nerve Growth Factors/pharmacology
Neuroblastoma
Neuroprotective Agents/*metabolism
Neurotrophin 3
Phospholipase C gamma
Phosphorylation
Receptor
Receptor Protein-Tyrosine Kinases/*metabolism
Receptors
Serotonin/metabolism
Signal Transduction/drug effects/*physiology
Tretinoin/pharmacology
trkC
Tumor Cells
Type C Phospholipases/metabolism
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.neuroscience.2016.03.010" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.neuroscience.2016.03.010</a>
Pages
177–190
Volume
324
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Intrinsic plasticity induced by group II metabotropic glutamate receptors via enhancement of high-threshold KV currents in sound localizing neurons.
Publisher
An entity responsible for making the resource available
Neuroscience
Date
A point or period of time associated with an event in the lifecycle of the resource
2016
2016-06
Subject
The topic of the resource
Acoustic Stimulation/methods; Action Potentials/drug effects/physiology; Animals; Auditory Pathways/drug effects/*physiology; Brain/drug effects/physiology; Chick Embryo; Glutamic Acid/metabolism; metabotropic glutamate receptor; Metabotropic Glutamate/agonists/*metabolism; neuromodulation; Neuronal Plasticity/drug effects/*physiology; Neurons/drug effects/*physiology; nucleus laminaris; Patch-Clamp Techniques; Potassium Channels; Potassium/metabolism; Protein Kinase C/metabolism; Receptors; Sound Localization/drug effects/*physiology; Tissue Culture Techniques; Type C Phospholipases/metabolism; voltage-gated potassium channel; Voltage-Gated/*metabolism
Creator
An entity primarily responsible for making the resource
Hamlet W R; Lu Y
Description
An account of the resource
Intrinsic plasticity has emerged as an important mechanism regulating neuronal excitability and output under physiological and pathological conditions. Here, we report a novel form of intrinsic plasticity. Using perforated patch clamp recordings, we examined the modulatory effects of group II metabotropic glutamate receptors (mGluR II) on voltage-gated potassium (KV) currents and the firing properties of neurons in the chicken nucleus laminaris (NL), the first central auditory station where interaural time cues are analyzed for sound localization. We found that activation of mGluR II by synthetic agonists resulted in a selective increase of the high-threshold KV currents. More importantly, synaptically released glutamate (with reuptake blocked) also enhanced the high-threshold KV currents. The enhancement was frequency-coding region dependent, being more pronounced in low-frequency neurons compared to middle- and high-frequency neurons. The intracellular mechanism involved the Gbetagamma signaling pathway associated with phospholipase C and protein kinase C. The modulation strengthened membrane outward rectification, sharpened action potentials, and improved the ability of NL neurons to follow high-frequency inputs. These data suggest that mGluR II provides a feedforward modulatory mechanism that may regulate temporal processing under the condition of heightened synaptic inputs.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/j.neuroscience.2016.03.010" target="_blank" rel="noreferrer noopener">10.1016/j.neuroscience.2016.03.010</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2016
Acoustic Stimulation/methods
Action Potentials/drug effects/physiology
Animals
Auditory Pathways/drug effects/*physiology
Brain/drug effects/physiology
Chick Embryo
Department of Anatomy & Neurobiology
Glutamic Acid/metabolism
Hamlet W R
Lu Y
metabotropic glutamate receptor
Metabotropic Glutamate/agonists/*metabolism
NEOMED College of Medicine
neuromodulation
Neuronal Plasticity/drug effects/*physiology
Neurons/drug effects/*physiology
Neuroscience
nucleus laminaris
Patch-Clamp Techniques
Potassium Channels
Potassium/metabolism
Protein Kinase C/metabolism
Receptors
Sound Localization/drug effects/*physiology
Tissue Culture Techniques
Type C Phospholipases/metabolism
voltage-gated potassium channel
Voltage-Gated/*metabolism