1
40
2
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Pages
45–58
Issue
1
Volume
3
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Distribution of tyrosine hydroxylase- and serotonin-immunoreactive cells in the central nervous system of the thornback guitarfish, Platyrhinoidis triseriata.
Publisher
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Journal of chemical neuroanatomy
Date
A point or period of time associated with an event in the lifecycle of the resource
1990
1990-02
Subject
The topic of the resource
Animals; Immunohistochemistry; Tyrosine 3-Monooxygenase/*metabolism; Serotonin/*metabolism; Fishes/*metabolism; Central Nervous System/cytology/*metabolism
Creator
An entity primarily responsible for making the resource
Stuesse S L; Cruce W L; Northcutt R G
Description
An account of the resource
Brainstem reticular nuclei of amniotes (mammals, birds and reptiles) may share a common phylogenetic origin as demonstrated by their many shared features (hodology, cytoarchitectonics, presence of neurochemicals). By studying characteristics of these nuclei in outgroups of amniotes, we hope to obtain clues about the phylogeny of the reticular formation. In this paper we report the distribution of immunoreactivity to tyrosine hydroxylase (TH) and serotonin (5-HT) in the brain of an elasmobranch, the thornback guitarfish, Platyrhinoidis triseriata. Our working hypothesis is that if morphologically and immunohistochemically similar cell groups are present, they are homologous to cell groups in amniotes. Thus we have used mammalian terminology. The dorsal and lateral pallium of the telencephalon and many diencephalic nuclei contained TH+ cells. In the mesencephalon, TH+ cell groups were located in raphe linearis, the ventral tegmentum and substantia nigra. The rhombencephalon contained TH+ cells in a putative locus coeruleus (A6), and a subcoeruleus group. Probable A5, A2/C2 and A1/C1 groups were also located. A few 5-HT+ cells were located in the telencephalon and many were found in the diencephalon. In the mesencephalon,
Rights
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1990
Animals
Central Nervous System/cytology/*metabolism
Cruce W L
Fishes/*metabolism
Immunohistochemistry
Journal of chemical neuroanatomy
Northcutt R G
Serotonin/*metabolism
Stuesse S L
Tyrosine 3-Monooxygenase/*metabolism
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.neuro.2017.03.008" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.neuro.2017.03.008</a>
Pages
99–106
Volume
60
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Single low doses of MPTP decrease tyrosine hydroxylase expression in the absence of overt neuron loss.
Publisher
An entity responsible for making the resource available
Neurotoxicology
Date
A point or period of time associated with an event in the lifecycle of the resource
2017
2017-05
Subject
The topic of the resource
1-Methyl-4-phenyl-1; 2; 3; 6-tetrahydropyridine/*administration & dosage; Animals; Catecholamines/metabolism; Cell Count; Corpus Striatum/*drug effects/metabolism; Dopamine; Dopamine transporter; Dopaminergic Neurons/*drug effects/metabolism; Inbred C57BL; Male; Mice; MPTP; MPTP Poisoning; Parkinsonian Disorders/*metabolism/*pathology; Stereology; Substantia Nigra/*drug effects/metabolism; Tyrosine 3-Monooxygenase/*metabolism; Tyrosine hydroxylase; Vesicular monoamine transporter
Creator
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Alam Gelareh; Edler Melissa; Burchfield Shelbie L; Richardson Jason R
Description
An account of the resource
Parkinson's disease (PD) is the second most common age-related neurodegenerative disease. 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) is a prototypical neurotoxicant used in mice to mimic primary features of PD pathology including striatal dopamine depletion and dopamine neuron loss in the substantia nigra pars compacta (SNc). In the literature, there are several experimental paradigms involving multiple doses of MPTP that are used to elicit dopamine neuron loss. However, a recent study reported that a single low dose caused significant loss of dopamine neurons. Here, we determined the effect of a single intraperitoneal injection of one of three doses of MPTP (0.1, 2 and 20mg/kg) on dopamine neurons, labeled by tyrosine hydroxylase (TH(+)), and total neuron number (Nissl(+)) in the SNc using unbiased stereological counting. Data reveal a significant loss of neurons in the SNc (TH(+) and Nissl(+)) only in the group treated with 20mg/kg MPTP. Groups treated with lower dose of MPTP (0.1 and 2mg/kg) only showed significant loss of TH(+) neurons rather than TH(+) and Nissl(+) neurons. Striatal dopamine levels were decreased in the groups treated with 2 and 20mg/kg MPTP and striatal terminal markers including, TH and the dopamine transporter (DAT), were only decreased in the groups treated with 20mg/kg MPTP. These data demonstrate that lower doses of MPTP likely result in loss of TH expression rather than actual dopamine neuron loss in the SN. This finding reinforces the need to measure both total neuron number along with TH(+) cells in determining dopamine neuron loss.
Identifier
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<a href="http://doi.org/10.1016/j.neuro.2017.03.008" target="_blank" rel="noreferrer noopener">10.1016/j.neuro.2017.03.008</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1-Methyl-4-phenyl-1
2
2017
3
6-tetrahydropyridine/*administration & dosage
Alam Gelareh
Animals
Burchfield Shelbie L
Catecholamines/metabolism
Cell Count
Corpus Striatum/*drug effects/metabolism
Department of Pharmaceutical Sciences
Dopamine
Dopamine transporter
Dopaminergic Neurons/*drug effects/metabolism
Edler Melissa
Inbred C57BL
Male
Mice
MPTP
MPTP Poisoning
NEOMED College of Pharmacy
Neurotoxicology
Parkinsonian Disorders/*metabolism/*pathology
Richardson Jason R
Stereology
Substantia Nigra/*drug effects/metabolism
Tyrosine 3-Monooxygenase/*metabolism
Tyrosine hydroxylase
Vesicular monoamine transporter