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Text
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URL Address
<a href="http://doi.org/10.1161/01.atv.14.10.1586" target="_blank" rel="noreferrer noopener">http://doi.org/10.1161/01.atv.14.10.1586</a>
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Pages
1586-1593
Issue
10
Volume
14
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Title
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TAMOXIFEN AND ESTROGEN LOWER CIRCULATING LIPOPROTEIN(A) CONCENTRATIONS IN HEALTHY POSTMENOPAUSAL WOMEN
Publisher
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Arteriosclerosis and Thrombosis
Date
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1994
1994-10
Subject
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binding-proteins; breast-cancer; cardiovascular risk-factors; Cardiovascular System & Cardiology; coronary heart-disease; estrogen replacement; growth factor-i; insulin-like growth factor i; lipoprotein(a); lp(a) lipoprotein; menopause; replacement therapy; serum lipoprotein(a); smooth-muscle cells; somatomedin-c; tamoxifen; therapy
Creator
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Shewmon D A; Stock J L; Rosen C J; Heiniluoma K M; Hogue M M; Morrison A; Doyle E M; Ukena T; Weale V; Baker S
Description
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Data in the literature suggest that circulating levels of lipoprotein(a) [Lp(a)] and insulinlike growth factor I (IGF-I) respond similarly to therapy with growth hormone, estrogen, or tamoxifen. To more clearly document these relations, we designed a randomized, double-blind, placebo-controlled study of the effects of tamoxifen and continuous estrogen on circulating levels of Lp(a), IGF-I, and IGF binding protein 3 (IGFBP-3) in healthy postmenopausal women. Both estrogen and tamoxifen decreased serum levels of IGF-I to 30% below baseline during the 3 months of treatment, while IGFBP-3 levels were unchanged. Plasma Lp(a) levels decreased to 24% below baseline after 1 month of treatment with either estrogen or tamoxifen (P < .05 for estrogen only); after 3 months Lp(a) decreased to 34% below baseline with tamoxifen therapy (P < .05) but returned to only 16% below baseline with estrogen. The correlation between Lp(a) and IGF-I was highly significant (P < .0001). We conclude that (1) tamoxifen lowers plasma Lp(a) levels in healthy postmenopausal women, (2) the suppressive effects of tamoxifen and estrogen on circulating Lp(a) concentration diverge after the first month of therapy, and (3) circulating levels of Lp(a) and IGF-I are strongly correlated with each other, an indication that they may share regulatory influences.
Identifier
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<a href="http://doi.org/10.1161/01.atv.14.10.1586" target="_blank" rel="noreferrer noopener">10.1161/01.atv.14.10.1586</a>
Format
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Journal Article
1994
Arteriosclerosis and Thrombosis
Baker S
binding-proteins
breast-cancer
cardiovascular risk-factors
Cardiovascular System & Cardiology
coronary heart-disease
Doyle E M
estrogen replacement
growth factor-i
Heiniluoma K M
Hogue M M
insulin-like growth factor i
Journal Article
Lipoprotein(a)
lp(a) lipoprotein
Menopause
Morrison A
replacement therapy
Rosen C J
serum lipoprotein(a)
Shewmon D A
smooth-muscle cells
somatomedin-c
Stock J L
Tamoxifen
therapy
Ukena T
Weale V