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Text
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URL Address
<a href="http://doi.org/10.1155/2019/3561501" target="_blank" rel="noreferrer noopener">http://doi.org/10.1155/2019/3561501</a>
Pages
1–8
NEOMED College
NEOMED College of Medicine
NEOMED Department
NEOMED Student Publications
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Title
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Adjuvant Chemotherapy in Uterine Leiomyosarcoma: Trends and Factors Impacting Usage.
Publisher
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Sarcoma
Date
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2019
2019-02-10
Subject
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Neoplasm Staging; Odds Ratio; Age Factors; Survival; Confidence Intervals; Neoplasm Metastasis; Human; Multiple Regression; Chemotherapy; Chemoradiotherapy; Cox Proportional Hazards Model; Kaplan-Meier Estimator; Uterine Neoplasms – Diagnosis; Lymph Nodes – Pathology; Adjuvant – Trends; Adjuvant – Utilization; Leiomyosarcoma – Diagnosis; Leiomyosarcoma – Prognosis; Leiomyosarcoma – Therapy; Uterine Neoplasms – Prognosis; Uterine Neoplasms – Therapy
Creator
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Patel Dhara; Handorf Elizabeth; von Mehren Margaret; Martin Lainie; Movva Sujana
Description
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Objectives. The benefit of adjuvant chemotherapy in patients with localized uterine leiomyosarcoma (LMS) remains unclear due to a lack of randomized studies and data only from small retrospective series to rely on. We sought to identify factors associated with the administration of chemotherapy and to determine the trends in the usage of adjuvant chemotherapy in patients with nonmetastatic uterine LMS. Methods. Patients diagnosed with nonmetastatic uterine LMS between 2004 and 2014 were identified from the National Cancer Database (NCDB). Multiple regression was used to determine factors with a significant impact on patient receipt of chemotherapy. Kaplan–Meier curves and the Cox model were used to determine the effect of adjuvant chemotherapy on overall survival (OS). Results. 2,732 uterine LMS patients were identified. Patients older than 65 were less likely to receive chemotherapy than their younger counterparts. Patients with stage I or stage II cancer were less likely to receive chemotherapy, whereas individuals with positive regional lymph nodes and those who had received radiation were more likely. In this cohort, adjuvant chemotherapy had no significant impact on OS (HR, 1.04; 95% CI, 0.90–1.22; P=0.5768). However, administration of chemotherapy significantly increased from 2004 to 2014 (P\textless0.0001). Conclusions. Expected tumor characteristics such as higher stage of tumor were associated with receipt of chemotherapy. Although adjuvant chemotherapy demonstrated no benefit over observation on OS in patients with nonmetastatic LMS, the number of patients being treated with chemotherapy continued to increase from 2004 to 2014.
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<a href="http://doi.org/10.1155/2019/3561501" target="_blank" rel="noreferrer noopener">10.1155/2019/3561501</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2019
Adjuvant – Trends
Adjuvant – Utilization
Age Factors
Chemoradiotherapy
Chemotherapy
Confidence Intervals
Cox Proportional Hazards Model
Handorf Elizabeth
Human
Kaplan-Meier Estimator
Leiomyosarcoma – Diagnosis
Leiomyosarcoma – Prognosis
Leiomyosarcoma – Therapy
Lymph Nodes – Pathology
Martin Lainie
Movva Sujana
Multiple Regression
NEOMED College of Medicine Student
NEOMED Student Publications
Neoplasm Metastasis
Neoplasm Staging
Odds Ratio
Patel Dhara
Sarcoma
Survival
Uterine Neoplasms – Diagnosis
Uterine Neoplasms – Prognosis
Uterine Neoplasms – Therapy
von Mehren Margaret