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Text
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URL Address
<a href="http://doi.org/10.1016/0304-3940(96)12960-8" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0304-3940(96)12960-8</a>
Pages
157–160
Issue
3
Volume
215
Dublin Core
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Title
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In utero cocaine exposure decreases dopamine D1 receptor modulation of hippocampal long-term potentiation in the rabbit.
Publisher
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Neuroscience letters
Date
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1996
1996-09
Subject
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Animals; Cocaine/*pharmacology; Dopamine D1/*drug effects; Female; Hippocampus/*drug effects; Long-Term Potentiation/*drug effects; Rabbits; Receptors; Uterus/*drug effects
Creator
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Little J Z; Teyler T J
Description
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Cocaine increases the synaptic concentration of neurotransmitters by inhibiting catecholamine transporters. Disturbances of behavior and cellular physiology have been associated with prenatal cocaine exposure and are related to changes in dopamine transmission. Recently we found the magnitude of long-term potentiation (LTP) was greater in hippocampal slices from cocaine exposed offspring. In the hippocampus, D1 dopamine receptor antagonists inhibit the expression of LTP while agonists facilitate it. To test the functionality of the D1 receptor we examined the effect of the D1 antagonist SCH-23390 on LTP using a rabbit model of gestational cocaine exposure. Tetanization during exposure to the D1 antagonist
Identifier
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<a href="http://doi.org/10.1016/0304-3940(96)12960-8" target="_blank" rel="noreferrer noopener">10.1016/0304-3940(96)12960-8</a>
Rights
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1996
Animals
Cocaine/*pharmacology
Dopamine D1/*drug effects
Female
Hippocampus/*drug effects
Little J Z
Long-Term Potentiation/*drug effects
Neuroscience letters
Rabbits
Receptors
Teyler T J
Uterus/*drug effects