1
40
1
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1007/BF03347791" target="_blank" rel="noreferrer noopener">http://doi.org/10.1007/BF03347791</a>
Pages
855–860
Issue
11
Volume
17
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
The effect of estrogen administration in vivo upon catecholamine release in vitro from superfused hypothalamic tissue of ovariectomized pre-pubertal and adult mice.
Publisher
An entity responsible for making the resource available
Journal of endocrinological investigation
Date
A point or period of time associated with an event in the lifecycle of the resource
1994
1994-12
Subject
The topic of the resource
*Ovariectomy; Aging/*metabolism; Animals; Catecholamines/*metabolism; Dopamine/metabolism; Estradiol/*pharmacology; Female; Hypothalamus/*drug effects/metabolism; Mice; Norepinephrine/metabolism; Organ Size/drug effects; Potassium/pharmacology; Uterus/drug effects/growth & development
Creator
An entity primarily responsible for making the resource
Dluzen D; Attaran M; Liu B
Description
An account of the resource
In the present report we examined the effects of estrogen upon catecholamine release from superfused medial basal hypothalamic tissue fragments of pre-pubertal ovariectomized CD-1 mice. Prepubertal mice treated with estradiol benzoate (EB–5 micrograms x 2 days, sc), showed significantly reduced amounts of dopamine but no changes in norepinephrine release in response to a depolarizing concentration of potassium (30 mmol/L) compared with their respective groups receiving the oil vehicle. Since EB treatment reduced potassium stimulated dopamine release in these pre-pubertal mice, in a second experiment we compared the effects of EB versus oil vehicle treatment upon potassium stimulated dopamine release from the hypothalamus of the ovariectomized adult female mouse. Similar to that observed in the pre-pubertal mouse, EB treatment significantly reduced the amount of potassium stimulated dopamine release. Interestingly, the absolute amounts of potassium stimulated dopamine release was substantially greater in adult compared with pre-pubertal mice. These results demonstrate that the hypothalamic dopaminergic system of both pre-pubertal and adult mice show relatively similar responses to estrogen treatment but differ in absolute amounts of dopamine released.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1007/BF03347791" target="_blank" rel="noreferrer noopener">10.1007/BF03347791</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Ovariectomy
1994
Aging/*metabolism
Animals
Attaran M
Catecholamines/*metabolism
Dluzen D
Dopamine/metabolism
Estradiol/*pharmacology
Female
Hypothalamus/*drug effects/metabolism
Journal of endocrinological investigation
Liu B
Mice
Norepinephrine/metabolism
Organ Size/drug effects
Potassium/pharmacology
Uterus/drug effects/growth & development