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URL Address
<a href="http://doi.org/10.5414/cn109598" target="_blank" rel="noreferrer noopener">http://doi.org/10.5414/cn109598</a>
Pages
370–379
Issue
6
Volume
91
ISSN
0301-0430
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Title
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Endothelin-1 as a therapeutic target in autosomal dominant polycystic kidney disease
Publisher
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Clinical Nephrology
Date
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2019
2019-06
Subject
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proliferation; hypertension; receptor; expression; Urology & Nephrology; growth-factor; renal damage; endothelin-1; excretion; polycystic kidney disease; chronic kidney disease; ADPKD; endothelin-1 antagonists; autosomal dominant; tolvaptan; urinary endothelin-1; water permeability
Creator
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Raina R; Chauvin A; Vajapey R; Khare A; Krishnappa V
Description
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Aims: Endothelin-1 (ET-1) is associated with the pathophysiology of autosomal dominant polycystic kidney disease (ADPKD) via cyst progression. Elevated concentrations of ET-1 in ADPKD correlate with many phenotypic changes in the kidney such as renal cyst development, interstitial fibrosis, and glomerulosclerosis. In addition, an imbalance between renal ETA and ETB receptors possibly leads to more severe disease progression. The objective of this review is to determine whether evaluating the efficacy of these drugs in treatment of cystic kidney disease may be a worthwhile aim, as determined by results from animal and human models. Materials and methods: PubMed/Medline, Embase, and Google Scholar databases were searched using the key words "endothelin, endothelin-1 antagonists, and autosomal dominant polycystic kidney disease". All animal and human studies describing the effects of endothelin and endothelin-1 antagonists in ADPKD subjects were included in the review. Results: Urinary ET-1 concentrations could serve as a noninvasive surrogate biomarker for kidney ET-1 levels, as it is inversely associated with eGFR, independent of age, sex, and blood pressure. Elevated urinary excretion of ET-1 may be a biomarker for early renal injury. Antagonization of ET-1 may hopefully be a novel therapy for slowing progression of kidney damage in ADPKD. Conclusion: Based on the literature reviewed in this manuscript, it is proposed that further research evaluating the efficacy of endothelin antagonists in treatment of cystic kidney disease is warranted. More human studies need to be performed with larger sample sizes. Therefore, the recommendation for treatment is inconclusive at this time.
Identifier
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<a href="http://doi.org/10.5414/cn109598" target="_blank" rel="noreferrer noopener">10.5414/cn109598</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2019
ADPKD
Autosomal Dominant
Chauvin A
Chronic kidney disease
Clinical nephrology
Department of Internal Medicine
endothelin-1
endothelin-1 antagonists
excretion
expression
growth-factor
Hypertension
June 2019 Update
Khare A
Krishnappa V
NEOMED College of Graduate Studies Student
NEOMED College of Medicine
NEOMED College of Medicine Student
NEOMED Student Publications
polycystic kidney disease
proliferation
Raina R
Receptor
renal damage
Tolvaptan
urinary endothelin-1
Urology & Nephrology
Vajapey R
water permeability