1 40 1 Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. URL Address <a href="http://doi.org/10.1007/s00467-008-1005-9" target="_blank" rel="noreferrer noopener">http://doi.org/10.1007/s00467-008-1005-9</a> Rights Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s). Pages 301-308 Issue 2 Volume 24 Search for Full-text Locate full-text within NEOMED Library's e-journal collections <p>Users with a NEOMED Library login can search for full-text journal articles at the following url: <a href="https://libraryguides.neomed.edu/home">https://libraryguides.neomed.edu/home</a></p> Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Membranous glomerulonephritis: treatment response and outcome in children Publisher An entity responsible for making the resource available Pediatric Nephrology Date A point or period of time associated with an event in the lifecycle of the resource 2009 2009-02 Subject The topic of the resource childhood; chlorambucil; clinical course; cyclophosphamide; cyclophosphamide; glomerular-filtration-rate; glomerulonephropathy; glomerulosclerosis; Membranous; Membranous glomerulonephritis; methylprednisolone; nephropathy; nephrotic; Nephrotic syndrome; Pediatrics; syndrome; systemic lupus erythematosus; Urology & Nephrology Creator An entity primarily responsible for making the resource Valentini R P; Mattoo T K; Kapur G; Imam A Description An account of the resource The aim of this study was to characterize clinical features, treatment response, and outcome of idiopathic membranous glomerulonephritis (MGN) in a single-center cohort of children. A retrospective review of biopsy-proven idiopathic MGN in 12 children (mean age 11.9 years) was undertaken. Presentation was nephrotic syndrome (NS) (75%), hematuria/proteinuria (17%), and asymptomatic proteinuria (8%). Ten patients (83%) with NS and nephrotic range proteinuria (NRP) were treated with prednisone, and two patients with non-NRP were not treated with immunosuppressive medications. Steroid response in the treated patients was complete (10%), partial (40%), and absent (50%), respectively. Oral cyclophosphamide was used in seven patients of whom five were steroid resistant, one was steroid dependent, and one was partially responsive. At the mean follow up of 27 months, outcome parameters included an estimated glomerular filtration rate of 128 cc/min per 1.73 m(2), albumin of 4.2 gm/dL, and a urine protein/creatinine ratio of 0.87 [median 0.16 (range 0.02-6.52)]. Remission was complete in 75% of the patients and partial in 17%. One patient (8%) with chronic kidney disease (stage 2) was unresponsive to therapy. Complete remission was significantly associated with the absence of chronic histological changes (p=0.03). In conclusion, children with NS and/or NRP associated with MGN appear to have a good prognosis when treated with a combination of corticosteroids and cyclophosphamide. Identifier An unambiguous reference to the resource within a given context <a href="http://doi.org/10.1007/s00467-008-1005-9" target="_blank" rel="noreferrer noopener">10.1007/s00467-008-1005-9</a> Format The file format, physical medium, or dimensions of the resource Journal Article 2009 childhood chlorambucil clinical course cyclophosphamide glomerular-filtration-rate glomerulonephropathy glomerulosclerosis Imam A Journal Article Kapur G Mattoo T K Membranous Membranous glomerulonephritis methylprednisolone nephropathy nephrotic Nephrotic syndrome pediatric nephrology Pediatrics Syndrome systemic lupus erythematosus Urology & Nephrology Valentini R P