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40
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Text
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URL Address
<a href="http://doi.org/10.1055/s-0039-1681058" target="_blank" rel="noreferrer noopener">http://doi.org/10.1055/s-0039-1681058</a>
Pages
475-482
Issue
5
Volume
37
ISSN
1098-8785 0735-1631 0735-1631
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Update Year & Number
Hospital List
Dublin Core
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Title
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Effect of Treatment of Mild Gestational Diabetes on Long-Term Maternal Outcomes.
Publisher
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American Journal of Perinatology
Date
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2020
2020-04
Subject
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Humans; Pregnancy; Adult; Female; Blood Glucose/analysis; Surveys and Questionnaires; Follow-Up Studies; Multivariate Analysis; Insulin Resistance; Diabetes Mellitus/prevention & control; Diabetes Gestational/diagnosis/therapy; Metabolic Syndrome/prevention & control; Obesity/prevention & control
Creator
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Casey BM; Rice MM; Landon MB; Varner MW; Reddy UM; Wapner RJ; Rouse DJ; Biggio JR; Thorp JM; Chien EK; Saade GR; Peaceman AM; Blackwell SC; Van Dorsten JP
Description
An account of the resource
OBJECTIVE: The main purpose of this article is to evaluate whether identification and treatment of women with mild gestational diabetes mellitus (GDM) during pregnancy affects subsequent maternal body mass index (BMI), anthropometry, metabolic syndrome, and risk of diabetes. STUDY DESIGN: This is a follow-up study of women who participated in a randomized controlled treatment trial for mild GDM. Women were enrolled between 5 and 10 years after their index pregnancy. Participants underwent blood pressure, height, weight, and anthropometric measurements by trained nursing personnel using a standardized approach. A nurse-assisted questionnaire regarding screening and treatment of diabetes or hypercholesterolemia, diet, and physical activity was completed. Laboratory evaluation included fasting serum glucose, fasting insulin, oral glucose tolerance test, and a lipid panel. Subsequent diabetes, metabolic syndrome, obesity, and adiposity in those diagnosed with mild GDM and randomized to nutritional counseling and medical therapy (treated) were compared with those who underwent routine pregnancy management (untreated). Multivariable analyses were performed adjusting for race/ethnicity and years between randomization and follow-up visit. RESULTS: Four-hundred fifty-seven women with mild GDM during the index pregnancy were included in this analysis (243 treated; 214 untreated) and evaluated at a median 7 years after their index pregnancy. Baseline and follow-up characteristics were similar between treatment groups. Frequency of diabetes (9.2 vs. 8.5%, p =0.80), metabolic syndrome (32.2 vs. 34.3%, p =0.63), as well as adjusted mean values of homeostasis model assessment for insulin resistance (2.5 vs. 2.3, p =0.11) and BMI (29.4 vs. 29.1 kg/m(2), p =0.67) were also not different. CONCLUSION: Identification and treatment of women with mild GDM during pregnancy had no discernible impact on subsequent diabetes, metabolic syndrome, or obesity 7 years after delivery.
Identifier
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<a href="http://doi.org/10.1055/s-0039-1681058" target="_blank" rel="noreferrer noopener">10.1055/s-0039-1681058</a>
Rights
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Format
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journalArticle
2020
Adult
American Journal of Perinatology
Biggio JR
Blackwell SC
Blood Glucose/analysis
Casey BM
Chien EK
Diabetes Gestational/diagnosis/therapy
Diabetes Mellitus/prevention & control
Female
Follow-Up Studies
Hospital List
Humans
Insulin Resistance
journalArticle
Landon MB
Metabolic Syndrome/prevention & control
Multivariate Analysis
Obesity/prevention & control
Peaceman AM
Pregnancy
Reddy UM
Rice MM
Rouse DJ
Saade GR
Surveys and Questionnaires
Thorp JM
Van Dorsten JP
Varner MW
Wapner RJ