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40
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Text
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URL Address
<a href="http://doi.org/10.1016/j.canlet.2010.01.030" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.canlet.2010.01.030</a>
Pages
1–12
Issue
1
Volume
294
Dublin Core
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Title
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Vanadium in the detection, prevention and treatment of cancer: the in vivo evidence.
Publisher
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Cancer letters
Date
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2010
2010-08
Subject
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10-Dimethyl-1; 2-benzanthracene; 9; Animal; Animals; Biological; Breast Neoplasms – Chemically Induced; Breast Neoplasms – Diagnosis; Breast Neoplasms – Drug Therapy; Cell Division – Drug Effects; Cell Division/drug effects; Disease Models; Experimental/chemically induced/diagnosis/drug therapy; Experimental/drug therapy/pathology; Female; Glioblastoma/drug therapy; Glioma – Drug Therapy; Heterologous; Humans; Hydrocarbons; Male; Mammary Neoplasms; Metals; Metals – Diagnostic Use; Metals – Therapeutic Use; Models; Neoplasm Staging; Neoplasm Transplantation; Neoplasms; Neoplasms – Diagnosis; Neoplasms – Drug Therapy; Neoplasms – Pathology; Neoplasms – Prevention and Control; Neoplasms/*diagnosis/drug therapy/prevention & control; Organometallic Compounds – Therapeutic Use; Organometallic Compounds/therapeutic use; Rats; Trace Elements – Diagnostic Use; Trace Elements – Therapeutic Use; Trace Elements/therapeutic use; Transplantation; Vanadium Compounds; Vanadium Compounds – Therapeutic Use; Vanadium Compounds/therapeutic use/toxicity; Vanadium/*therapeutic use/toxicity; Xenografts
Creator
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Bishayee Anupam; Waghray Abhijeet; Patel Mehool A; Chatterjee Malay
Description
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Vanadium, a dietary micronutrient, is yet to be established as an essential part of the human diet. Over the past century, several biological effects of vanadium, such as insulin-mimetic action as well as amelioration of hyperlipidemia and hypertension, have been discovered. This transition element is known to influence a battery of enzymatic systems, namely phosphatases, ATPases, peroxidases, ribonucleases, protein kinases and oxidoreductases. Multiple biochemical and molecular actions of vanadium have been implicated in its inhibitory effects on various tumor cells of human origin. Successful in vitro studies over the past few decades have advanced the anticancer research on vanadium into the preclinical stage. Vanadium in several animal cancer models provides protection against all stages of carcinogenesis–initiation, promotion, and progression. This review focuses on the current advances in cancer prevention and treatment as well as early detection by vanadium compounds in preclinical animal models while pointing to possible mechanisms of such diverse beneficial effects. Clinical pharmacokinetic and potential toxicity studies on vanadium are also highlighted in this review. Supporting and challenging evidence as well as future directions of vanadium research exploring the possibility of using this dietary agent for detection, prevention and treatment of human cancers are critically discussed.
Identifier
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<a href="http://doi.org/10.1016/j.canlet.2010.01.030" target="_blank" rel="noreferrer noopener">10.1016/j.canlet.2010.01.030</a>
Rights
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
10-Dimethyl-1
2-benzanthracene
2010
9
Animal
Animals
Biological
Bishayee Anupam
Breast Neoplasms – Chemically Induced
Breast Neoplasms – Diagnosis
Breast Neoplasms – Drug Therapy
Cancer letters
Cell Division – Drug Effects
Cell Division/drug effects
Chatterjee Malay
Disease Models
Experimental/chemically induced/diagnosis/drug therapy
Experimental/drug therapy/pathology
Female
Glioblastoma/drug therapy
Glioma – Drug Therapy
Heterologous
Humans
Hydrocarbons
Male
Mammary Neoplasms
Metals
Metals – Diagnostic Use
Metals – Therapeutic Use
Models
Neoplasm Staging
Neoplasm Transplantation
Neoplasms
Neoplasms – Diagnosis
Neoplasms – Drug Therapy
Neoplasms – Pathology
Neoplasms – Prevention and Control
Neoplasms/*diagnosis/drug therapy/prevention & control
Organometallic Compounds – Therapeutic Use
Organometallic Compounds/therapeutic use
Patel Mehool A
Rats
Trace Elements – Diagnostic Use
Trace Elements – Therapeutic Use
Trace Elements/therapeutic use
Transplantation
Vanadium Compounds
Vanadium Compounds – Therapeutic Use
Vanadium Compounds/therapeutic use/toxicity
Vanadium/*therapeutic use/toxicity
Waghray Abhijeet
Xenografts