Circadian variation in cell-adhesion molecule expression by normal human leukocytes.
*Circadian Rhythm; Adult; CD11a Antigen/metabolism; CD11b Antigen/metabolism; Cell Adhesion Molecules/*metabolism; Female; Flow Cytometry; Humans; Integrin alpha Chains/metabolism; Intercellular Adhesion Molecule-1/metabolism; L-Selectin/metabolism; Leukocytes/*metabolism; Lymphocytes/metabolism; Male; Middle Aged; Monocytes/metabolism; Neutrophils/metabolism
Adhesion molecules located on the surface of blood-borne leukocytes permit adherence of leukocytes to the microvascular endothelium, diapedesis of leukocytes across vessel walls, formation of intimate multicell interactions, and enhanced transmembrane signal transduction. Since some leukocyte-mediated immune functions exhibit nocturnal intensification, the current study was conducted to investigate the hypothesis that expression of selected cell adhesion molecules (CAM) varies with circadian periodicity. Blood was collected from normal human donors over a 24-h period and CAM expression by monocytes, neutrophils, and lymphocytes evaluated by monoclonal antibody binding and flow cytometry. All leukocyte classes exhibited significant circadian-like variation (p \textless 0.05) in CD62L (L-selectin) expression. Similarly, a diurnal variation (p \textless 0.05) in monocyte and neutrophil CD54 (ICAM-1) was observed. Finally, neutrophils demonstrated a circadian-like variation (p \textless 0.05) in CD11a (LFA-1a). The rhythmic alterations in CAM expression may be clinically relevant, since changes in CAM expression have the potential to modulate the leukocyte-induced pathogenesis associated with disease progressions such as nocturnal asthma, the nighttime exacerbations of rheumatoid arthritis, and the high nocturnal incidence of cerebrovascular and cardiovascular crisis.
Niehaus Gary D; Ervin Elyce; Patel Amit; Khanna Kamal; Vanek Vincent W; Fagan Diana L
Canadian journal of physiology and pharmacology
2002
2002-10
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
<a href="http://doi.org/10.1139/y02-121" target="_blank" rel="noreferrer noopener">10.1139/y02-121</a>
The Use of Serum Albumin as a Prognostic or Nutritional Marker and The Pros and Cons of IV Albumin Therapy.
Serum albumin is a poor nutritional marker, but it is a good prognostic marker correlating with morbidity and mortality. However, IV albumin administration in hypoalbuminemic patients does not decrease tube feeding-associated diarrhea or intolerance, nor does it improve clinical outcome, so it is not cost-effective. In selected situations, colloid solutions may be helpful; however, nonprotein colloids are preferred and rarely is IV albumin indicated.
Vanek Vincent W
Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition
1998
1998-06
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
<a href="http://doi.org/10.1002/j.1941-2452.1998.tb03058.x" target="_blank" rel="noreferrer noopener">10.1002/j.1941-2452.1998.tb03058.x</a>
Providing Nutrition Support in the Electronic Health Record Era: The Good, the Bad, and the Ugly.
Time Factors; Health Personnel; Nutritional Support; Safety; Human; Questionnaires; Descriptive Statistics; Summated Rating Scaling; Documentation; Electronic Order Entry; Product Evaluation; Acute Care; America; Electronic Health Records – Methods
Vanek Vincent W
Nutrition in Clinical Practice
2012
2012-12
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
<a href="http://doi.org/10.1177/0884533612463440" target="_blank" rel="noreferrer noopener">10.1177/0884533612463440</a>