Tromantadine inhibits a late step in herpes simplex virus type 1 replication and syncytium formation.
Creator
Ickes D E; Venetta T M; Phonphok Y; Rosenthal K S
Publisher
Antiviral research
Date
1990
1990-08
Description
Addition of tromantadine after virus penetration inhibited HSV-1 induced syncytium formation and virus production in HEp-2 and VERO cells and acted additively with neutralizing antibody in blocking virus spread and cytopathology. Inhibition of syncytium formation in VERO cells infected with 0.01 pfu/cell of
Mild acidic pH inhibition of the major pathway of herpes simplex virus entry into HEp-2 cells.
Creator
Rosenthal K S; Killius J; Hodnichak C M; Venetta T M; Gyurgyik L; Janiga K
Publisher
The Journal of general virology
Date
1989
1989-04
Description
Penetration of the KOS strain of herpes simplex virus type 1 (HSV-1) and the MS and 333 strains of herpes simplex virus type 2 (HSV-2) into HEp-2 cells at pH 6.3 was at least 100-fold less efficient than at pH 7.4. Penetration of two low passage clinical isolates was completely blocked at pH 6.3. The syncytium-forming