Tromantadine Inhibits Herpes-simplex Virus-induced Syncytia
Pharmacology & Pharmacy; Virology
Ickes D E; Venetta T M; Rosenthal K S
Antiviral Research
1988
1988-01
Journal Article or Conference Abstract Publication
n/a
Tromantadine inhibits a late step in herpes simplex virus type 1 replication and syncytium formation.
Time Factors; Animals; Rabbits; Fluorescent Antibody Technique; Viral Envelope Proteins/biosynthesis; Virus Replication/*drug effects; Vero Cells; Antibodies; Amantadine/*analogs & derivatives/pharmacology; Cycloheximide/pharmacology; Giant Cells/*drug effects; Glycoproteins/biosynthesis; Membrane Proteins/biosynthesis; Neutralization Tests; Simplexvirus/*drug effects/physiology; Viral/immunology
Addition of tromantadine after virus penetration inhibited HSV-1 induced syncytium formation and virus production in HEp-2 and VERO cells and acted additively with neutralizing antibody in blocking virus spread and cytopathology. Inhibition of syncytium formation in VERO cells infected with 0.01 pfu/cell of
Ickes D E; Venetta T M; Phonphok Y; Rosenthal K S
Antiviral research
1990
1990-08
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
<a href="http://doi.org/10.1016/0166-3542(90)90045-9" target="_blank" rel="noreferrer noopener">10.1016/0166-3542(90)90045-9</a>
Mild acidic pH inhibition of the major pathway of herpes simplex virus entry into HEp-2 cells.
Animals; Cell Line; Electron; Electrophoresis; Endocytosis; Glycoproteins/analysis; Glycosylation; Humans; Hydrogen-Ion Concentration; Microscopy; Polyacrylamide Gel; Simplexvirus/*physiology/ultrastructure; Temperature; Time Factors; Vero Cells; Viral Proteins/analysis/metabolism
Penetration of the KOS strain of herpes simplex virus type 1 (HSV-1) and the MS and 333 strains of herpes simplex virus type 2 (HSV-2) into HEp-2 cells at pH 6.3 was at least 100-fold less efficient than at pH 7.4. Penetration of two low passage clinical isolates was completely blocked at pH 6.3. The syncytium-forming
Rosenthal K S; Killius J; Hodnichak C M; Venetta T M; Gyurgyik L; Janiga K
The Journal of general virology
1989
1989-04
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
<a href="http://doi.org/10.1099/0022-1317-70-4-857" target="_blank" rel="noreferrer noopener">10.1099/0022-1317-70-4-857</a>