1
40
2
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1002/(SICI)1098-1063(1998)8:4%3C373::AID-HIPO5%3E3.0.CO;2-I" target="_blank" rel="noreferrer noopener">http://doi.org/10.1002/(SICI)1098-1063(1998)8:4%3C373::AID-HIPO5%3E3.0.CO;2-I</a>
Pages
373–379
Issue
4
Volume
8
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
NMDA receptor-independent LTP in basal versus apical dendrites of CA1 pyramidal cells in rat hippocampal slice.
Publisher
An entity responsible for making the resource available
Hippocampus
Date
A point or period of time associated with an event in the lifecycle of the resource
1998
1905-6
Subject
The topic of the resource
Animals; Calcium Channel Blockers/pharmacology; Dendrites/*physiology; Electric Stimulation; Enzyme Inhibitors/pharmacology; Genistein/pharmacology; Hippocampus/cytology/*physiology; In Vitro Techniques; Inbred Strains; Long-Term Potentiation/drug effects/*physiology; Male; N-Methyl-D-Aspartate/*physiology; Phenols/pharmacology; Protein-Tyrosine Kinases/antagonists & inhibitors; Pyramidal Cells/*physiology; Rats; Receptors; Verapamil/pharmacology
Creator
An entity primarily responsible for making the resource
Cavus I; Teyler T J
Description
An account of the resource
The ability of hippocampal CA1 basal synapses to express N-methyl-D-aspartate (NMDA) receptor-independent long-term potentiation (non-NMDA LTP) was studied and compared to the simultaneously induced apical dendritic non-NMDA LTP. Non-NMDA LTP in basal and apical dendrites was induced using stimulation pattern similar to the sharp wave-associated CA3 bursts. Basal dendritic non-NMDA LTP was input-specific and displayed similar development and magnitude to the apical dendritic non-NMDA LTP. Both apical and basal dendritic non-NMDA potentiations were inhibited by the voltage-dependent calcium channel (VDCC) inhibitor verapamil and the tyrosine kinase inhibitors genistein and levandustin A. However, the difference in the degree and time course of these inhibitions suggests involvement of distinct mechanisms in the two dendritic subfields.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1002/(SICI)1098-1063(1998)8:4%3C373::AID-HIPO5%3E3.0.CO;2-I" target="_blank" rel="noreferrer noopener">10.1002/(SICI)1098-1063(1998)8:4%3C373::AID-HIPO5%3E3.0.CO;2-I</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1998
Animals
Calcium Channel Blockers/pharmacology
Cavus I
Dendrites/*physiology
Electric Stimulation
Enzyme Inhibitors/pharmacology
Genistein/pharmacology
Hippocampus
Hippocampus/cytology/*physiology
In Vitro Techniques
Inbred Strains
Long-Term Potentiation/drug effects/*physiology
Male
N-Methyl-D-Aspartate/*physiology
Phenols/pharmacology
Protein-Tyrosine Kinases/antagonists & inhibitors
Pyramidal Cells/*physiology
Rats
Receptors
Teyler T J
Verapamil/pharmacology
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1152/jn.1999.82.2.736" target="_blank" rel="noreferrer noopener">http://doi.org/10.1152/jn.1999.82.2.736</a>
Pages
736–740
Issue
2
Volume
82
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
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VDCCs and NMDARs underlie two forms of LTP in CA1 hippocampus in vivo.
Publisher
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Journal of neurophysiology
Date
A point or period of time associated with an event in the lifecycle of the resource
1999
1999-08
Subject
The topic of the resource
Animals; Calcium Channel Blockers/*pharmacology; Dizocilpine Maleate/pharmacology; Excitatory Amino Acid Antagonists/*pharmacology; Excitatory Postsynaptic Potentials/drug effects; Hippocampus/*drug effects; Long-Evans; Long-Term Potentiation/*drug effects; Male; Membrane Potentials/physiology; N-Methyl-D-Aspartate/*antagonists & inhibitors; Rats; Receptors; Verapamil/pharmacology
Creator
An entity primarily responsible for making the resource
Morgan S L; Teyler T J
Description
An account of the resource
N-methyl-D-aspartate receptor/channel (NMDAR) and voltage-dependent calcium channel (VDCC) antagonists applied independently reduce the magnitude of long-term potentiation (LTP) in area CA1 of the hippocampal slice preparation. When used in combination, the antagonists completely block the induction of LTP. In urethan-anesthetized rats we examined the effect of the NMDAR blocker MK-801 (0.1 mg/kg) and the VDCC blocker Verapamil (10 mg/kg) on LTP induction in area CA1. Extracellular recordings were obtained from stratum radiatum following stimulation of Schaffer collaterals. LTP was induced by a 200-Hz/100-ms tetanus repeated 10 times (2 s isi). Tetanus was given in the presence of intraperitoneal saline, MK-801, Verapamil, or both Verapamil and MK-801. When given separately, Verapamil and MK-801 both significantly reduced the magnitude of LTP as compared with control animals. When given together, the drugs blocked the induction of LTP completely. We conclude that like LTP in vitro, VDCCs and NMDAR underlie two forms of LTP in vivo.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1152/jn.1999.82.2.736" target="_blank" rel="noreferrer noopener">10.1152/jn.1999.82.2.736</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1999
Animals
Calcium Channel Blockers/*pharmacology
Dizocilpine Maleate/pharmacology
Excitatory Amino Acid Antagonists/*pharmacology
Excitatory Postsynaptic Potentials/drug effects
Hippocampus/*drug effects
Journal of neurophysiology
Long-Evans
Long-Term Potentiation/*drug effects
Male
Membrane Potentials/physiology
Morgan S L
N-Methyl-D-Aspartate/*antagonists & inhibitors
Rats
Receptors
Teyler T J
Verapamil/pharmacology