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Text
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URL Address
<a href="http://doi.org/10.1006/cbir.1993.1014" target="_blank" rel="noreferrer noopener">http://doi.org/10.1006/cbir.1993.1014</a>
Pages
919–934
Issue
10
Volume
17
Dublin Core
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Title
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Subcellular localization and antiviral activity of carminic acid/poly r(A-U) combinations.
Publisher
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Cell biology international
Date
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1993
1993-10
Subject
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Antiviral Agents/*pharmacology; Carmine/*analogs & derivatives/pharmacokinetics/pharmacology; Cell Nucleolus/metabolism; Cells; Chromatin/metabolism; Cultured; Doxorubicin/pharmacology; Drug Combinations; Drug Synergism; Fluorescence; Humans; Interferon-beta/biosynthesis/physiology; Microscopy; Phase-Contrast; Poly A-U/*pharmacokinetics/*pharmacology; Vesicular stomatitis Indiana virus/drug effects/growth & development; Viral Plaque Assay
Creator
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Krabill K; Jamison J M; Gilloteaux J; Summers J L
Description
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Carminic acid (CAR) enhances the antiviral activity of poly r(A-U) twelve-fold without increasing interferon induction, inactivating the vesicular stomatitis virus or inducing host cell cytotoxicity. Phase contrast photomicrographs of human foreskin fibroblasts (HSF) incubated with CAR alone, poly r(A-U) alone or with a CAR/poly r(A-U) combination illustrate that the CAR/poly r(A-U) combinations display altered subcellular distribution with the CAR being localized in the nucleoli and chromatin. Phase contrast and fluorescence photomicrographs of adriamycin (ADR)-treated and ADR/poly r(A-U)-treated HSF cells corroborate these findings. These results suggest that modulation of one or more nucleolar processes may be responsible for the enhanced antiviral activity.
Identifier
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<a href="http://doi.org/10.1006/cbir.1993.1014" target="_blank" rel="noreferrer noopener">10.1006/cbir.1993.1014</a>
Rights
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1993
Antiviral Agents/*pharmacology
Carmine/*analogs & derivatives/pharmacokinetics/pharmacology
Cell biology international
Cell Nucleolus/metabolism
Cells
Chromatin/metabolism
Cultured
Doxorubicin/pharmacology
Drug Combinations
Drug Synergism
Fluorescence
Gilloteaux J
Humans
Interferon-beta/biosynthesis/physiology
Jamison J M
Krabill K
Microscopy
Phase-Contrast
Poly A-U/*pharmacokinetics/*pharmacology
Summers J L
Vesicular stomatitis Indiana virus/drug effects/growth & development
Viral Plaque Assay