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Text
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URL Address
<a href="http://doi.org/10.1038/sj.onc.1207774" target="_blank" rel="noreferrer noopener">http://doi.org/10.1038/sj.onc.1207774</a>
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Pages
5858-5863
Issue
34
Volume
23
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Title
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The Ras-related protein AGS1/RASD1 suppresses cell growth
Publisher
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Oncogene
Date
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2004
2004-07
Subject
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activation; AGS1; apoptosis; binding protein; Biochemistry & Molecular Biology; cancer; Cell Biology; coupled receptors; Dexras1; Dexras1; G protein; gene; Genetics &; Heredity; hormone; identification; Integration; Oncology; RASD1; signal-transduction
Creator
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Vaidyanathan G; Cismowski M J; Wang G S; Vincent T S; Brown K D; Lanier S M
Description
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AGS1/RASD1 is a Ras-related protein identified as a dexamethasone-inducible cDNA and as a signal regulator in various functional and protein-interaction screens. As an initial approach to define the role of AGS1/RASD1 as a Ras-family member, we determined its influence on cell growth/survival. In clonogenic assays with NIH-3T3 murine fibroblast cells, the MCF-7 human breast cancer cell line and the human lung adenocarcinoma cell line A549, AGS1/RASD1 markedly diminished the number of G418-resistant colonies, whereas the Ras subgroup member K-Ras was without effect. A549 cell infection with adenovirus engineered to express AGS1/RASD1 (Ad.AGS1) inhibited log phase growth in vitro and increased the percentage of cells undergoing apoptosis. The anti-growth action was also observed in vivo as the expression of AGS1/RASD1 inhibited the subcutaneous tumor growth of A549 cells in athymic nude mice. These data indicate that AGS1/RASD1, a member of the Ras superfamily of small G-proteins that often promotes cell growth and tumor expansion, plays an active role in preventing aberrant cell growth.
Identifier
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<a href="http://doi.org/10.1038/sj.onc.1207774" target="_blank" rel="noreferrer noopener">10.1038/sj.onc.1207774</a>
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Journal Article
2004
activation
AGS1
Apoptosis
binding protein
Biochemistry & Molecular Biology
Brown K D
Cancer
Cell Biology
Cismowski M J
coupled receptors
Dexras1
G protein
gene
Genetics &
Heredity
hormone
identification
Integration
Journal Article
Lanier S M
Oncogene
oncology
RASD1
signal-transduction
Vaidyanathan G
Vincent T S
Wang G S