1
40
24
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1177/095632029000100601" target="_blank" rel="noreferrer noopener">http://doi.org/10.1177/095632029000100601</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
333-347
Issue
6
Volume
1
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Title
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Rna-intercalating Agent Interactions: In Vitro Antiviral Activity Studies
Publisher
An entity responsible for making the resource available
Antiviral Chemistry & Chemotherapy
Date
A point or period of time associated with an event in the lifecycle of the resource
1990
1990-12
Subject
The topic of the resource
Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Virology
Creator
An entity primarily responsible for making the resource
Jamison J M; Krabill K; Allen K A; Stuart S H; Tsai C C
Description
An account of the resource
Twenty intercalating agents were tested to examine the effects of intercalating dye-induced perturbations upon the antiviral activity of poly (adenylate-uridylate) [poly (A-U)]. Neither poly (A-U) alone nor each intercalative dye was an efficacious antiviral agent. When poly (A-U) was combined with major groove intercalating dyes (acridine orange or proflavine), no synergism was observed. When poly (A-U) was combined with minor groove intercalating dyes [ethidium (EB), propidium (PI), adriamycin (ADR) or daunomycin (DMN)] or minor/major groove intercalating dyes [9-aminoacridine (9-AA), N-2-methyl-9-hydroxy-ellipticine (NMHE) or N-2,N-6-dimethyl-9-hydroxy-ellipticine (DMHE)] the 50% effective doses (ED50) of the poly (A-U), 9-AA, ADR, DMHE, DMN, EB, NMHE and PI decreased 18-, 22-, 60-, 274-, 61-, 154-, 113- and 299-fold, respectively. When poly (A-U) was combined individually with 11 dyes whose mode of intercalation was not known, the ED50 of ametantrone (HAQ), chloroquine (CHL), mitoxantrone (DHAQ) and quinine (QUI) decreased 125-, 65-, 251- and 32-fold, respectively. These results suggest that the four dyes may intercalate into poly (A-U) from the minor groove. Ten (ADR, CHL, DMN, DHAQ, DMHE, EB, HAQ, NMHE, PI, QUI) of the 20 dyes evaluated exhibited significant synergism with poly (A-U), as quantified by the fractional inhibitory concentration index. Interferon (IFN) neutralization assays demonstrated that the IFN-inducing capability of the dye/poly (A-U) combinations approximated the sum of the capabilities of the poly (A-U) and the dyes employed. These results suggest that the majority of the dyes tested potentiate the antiviral activity of poly (A-U) without affecting the amount of IFN induced.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1177/095632029000100601" target="_blank" rel="noreferrer noopener">10.1177/095632029000100601</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
1990
Allen K A
Antiviral Chemistry & Chemotherapy
Biochemistry & Molecular Biology
Jamison J M
Journal Article or Conference Abstract Publication
Krabill K
Pharmacology & Pharmacy
Stuart S H
Tsai C C
Virology
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1177/095632029000100109" target="_blank" rel="noreferrer noopener">http://doi.org/10.1177/095632029000100109</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
53-60
Issue
1
Volume
1
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Dublin Core
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Title
A name given to the resource
Modulation Of The Antiviral Activity Of Poly (a-u) By Ethidium Bromide And Propidium Iodide
Publisher
An entity responsible for making the resource available
Antiviral Chemistry & Chemotherapy
Date
A point or period of time associated with an event in the lifecycle of the resource
1990
1990-02
Subject
The topic of the resource
Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Virology
Creator
An entity primarily responsible for making the resource
Jamison J M; Bonilla P J; Tsai C C
Description
An account of the resource
The role of ethidium bromide (EB) and propidium iodide (PI) in modulating the antiviral and interferon-inducing activities of poly(adenylate-uridylate) (poly (A-U )) was examined using the human foreskin fibro-blast-vesicular stomatitis virus (HSF-VSV) bioassay system in which the concentration of poly (A-U) was fixed at 0.05 mM or 0.2 mM while the EB or PI concentration was varied to produce variable EB (or PI)/ribonucleotide ratios ranging from 1: 16 to 2:1. EB, PI and poly (A-U) tested individually were not efficacious antiviral agents. When poly (A-U) was combined with the ethidium bromide or propidium iodide the antiviral activity was potentiated 15- to 22-fold at EB (or Pl)/ribonucleotide ratios in the region of 1/4. The interferon-inducing activity of the EB (or Pl)/poly (A-U) combinations were equal to the sum of the interferon-inducing activity of the poly (A-U) and the EB or (PI). These results indicate that the EB and PI potentiate the antiviral activity of the poly (A-U) without superinduction of interferon. The direct viral inactivation study demonstrated that EB, PI, poly (A-U) and the EB (or Pl)/poly (A-U) combinations did not inactivate the VSV at concentrations near the 50% viral inhibitory dose.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1177/095632029000100109" target="_blank" rel="noreferrer noopener">10.1177/095632029000100109</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
1990
Antiviral Chemistry & Chemotherapy
Biochemistry & Molecular Biology
Bonilla P J
Jamison J M
Journal Article or Conference Abstract Publication
Pharmacology & Pharmacy
Tsai C C
Virology
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1177/095632029000100502" target="_blank" rel="noreferrer noopener">http://doi.org/10.1177/095632029000100502</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
285-292
Issue
5
Volume
1
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Dublin Core
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Title
A name given to the resource
Enhancement Of The Antiviral Activity Of Poly (a-u) By Adriamycin And Daunomycin
Publisher
An entity responsible for making the resource available
Antiviral Chemistry & Chemotherapy
Date
A point or period of time associated with an event in the lifecycle of the resource
1990
1990-10
Subject
The topic of the resource
Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Virology
Creator
An entity primarily responsible for making the resource
Jamison J M; Bonilla P J; Tsai C C
Description
An account of the resource
The role of adriamycin (ADR) and daunomycin (DMN) in modulating the antiviral activity of poly (adeylate-uridylate) (poly (A-U)) was examined using a human foreskin fibroblast - vesicular stomatitis virus (HSF-VSV) bioassay in which the concentration of poly (A-U) was fixed at 0.05 mm or 0.2 mm while the ADR or DMN concentration was varied to produce ADR (or DMN)/ribonucleotide ratios ranging from 1:16 to 2:1. Poly (A-U), ADR and DMN were not efficacious antiviral agents when tested individually at the concentrations employed in the ADR (or DMN)/poly (A-U) combinations. When the ADR or DMN was combined with the poly (A-U) to produce ADR (or DMN)/poly (A-U) ratios of 1/6, the 50% effective doses (ED50) of the poly (A-U), ADR and DMN decreased 18, 104, and 185-fold, respectively. However, when ADR or DMN was combined with polyriboinosinic-polyribocytidylic acid [poly (I) . poly (C)], the ED50 of the ADR, DMN and the poly (I) . poly (C) were not affected. Interferon neutralization studies indicated that ADR, DMN, poly (A-U) and the ADR (or DMN)/poly (A-U) combination induced the production of interferon-beta (IFN-beta). The amount of IFN produced by the ADR (or DMN)/poly (A-U) combinations was equal to the sum of the IFN produced by their constituents. These results indicate that the ADR and DMN potentiate the antiviral activity of the poly (A-U) without affecting the amount of IFN induced. The direct viral inactivation study demonstrated that ADR, DMN, poly (A-U) and the ADR (or DMN)/poly (A-U) combinations do not inactivate the VSV at concentrations near the ED50.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1177/095632029000100502" target="_blank" rel="noreferrer noopener">10.1177/095632029000100502</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
1990
Antiviral Chemistry & Chemotherapy
Biochemistry & Molecular Biology
Bonilla P J
Jamison J M
Journal Article or Conference Abstract Publication
Pharmacology & Pharmacy
Tsai C C
Virology
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
n/a
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
111-111
Issue
1
Volume
9
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Dublin Core
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Title
A name given to the resource
Tromantadine Inhibits Herpes-simplex Virus-induced Syncytia
Publisher
An entity responsible for making the resource available
Antiviral Research
Date
A point or period of time associated with an event in the lifecycle of the resource
1988
1988-01
Subject
The topic of the resource
Pharmacology & Pharmacy; Virology
Creator
An entity primarily responsible for making the resource
Ickes D E; Venetta T M; Rosenthal K S
Identifier
An unambiguous reference to the resource within a given context
n/a
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
1988
Antiviral research
Ickes D E
Journal Article or Conference Abstract Publication
Pharmacology & Pharmacy
Rosenthal K S
Venetta T M
Virology
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0166-0934(84)90013-2" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0166-0934(84)90013-2</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
191-198
Issue
3
Volume
8
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Dublin Core
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Title
A name given to the resource
Visualization Of Herpes-simplex Virus Type-1 Attachment To Target-cells Using Staphylococcus-aureus As A Morphologic Tag
Publisher
An entity responsible for making the resource available
Journal of Virological Methods
Date
A point or period of time associated with an event in the lifecycle of the resource
1984
1984
Subject
The topic of the resource
Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology; Virology
Creator
An entity primarily responsible for making the resource
Hodnichak C M; Turleyshoger E; Mohanty J G; Rosenthal K S
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0166-0934(84)90013-2" target="_blank" rel="noreferrer noopener">10.1016/0166-0934(84)90013-2</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
1984
Biochemistry & Molecular Biology
Biotechnology & Applied Microbiology
Hodnichak C M
Journal Article or Conference Abstract Publication
Journal of virological methods
Mohanty J G
Rosenthal K S
Turleyshoger E
Virology
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
n/a
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
50-51
Volume
15
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Murine Leukemia Viruses Induce Characteristic Electrophysiological Changes In Specific Neuron Subsets: Implications For Spongiform Neuropathogenesis
Publisher
An entity responsible for making the resource available
Journal of Neurovirology
Date
A point or period of time associated with an event in the lifecycle of the resource
2009
2009
Subject
The topic of the resource
Neurosciences & Neurology; Virology
Creator
An entity primarily responsible for making the resource
Lynch W P; Li Y; Sivaramakrishnan S
Identifier
An unambiguous reference to the resource within a given context
n/a
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
2009
Journal of neurovirology
Li Y
Lynch W P
Neurosciences & Neurology
Sivaramakrishnan S
Virology
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
n/a
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
A32-A33
Issue
1
Volume
70
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Dublin Core
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Title
A name given to the resource
Nonsteroidal Anti-inflammatory Drugs, Indomethacin And Aspirin, Inhibit Herpes Simplex Virus Replication And Block Activation Of Nuclear Factor-kappab
Publisher
An entity responsible for making the resource available
Antiviral Research
Date
A point or period of time associated with an event in the lifecycle of the resource
2006
2006-05
Subject
The topic of the resource
Pharmacology & Pharmacy; Virology
Creator
An entity primarily responsible for making the resource
Faith S A; Bailey E; Docherty J J
Identifier
An unambiguous reference to the resource within a given context
n/a
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
2006
Antiviral research
Bailey E
Docherty J J
Faith S A
Pharmacology & Pharmacy
Virology
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
n/a
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
A66-A66
Issue
3
Volume
57
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Dublin Core
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Title
A name given to the resource
In Vivo Anti-herpes Simplex Virus Activity Of Resveratrol, A Cyclin Dependent Kinase Gene Inhibitor
Publisher
An entity responsible for making the resource available
Antiviral Research
Date
A point or period of time associated with an event in the lifecycle of the resource
2003
2003-02
Subject
The topic of the resource
Pharmacology & Pharmacy; Virology
Creator
An entity primarily responsible for making the resource
Docherty J J; Fu M M; Stoner T; Smith J; Lesniewski M; Tsai C C; Booth T
Identifier
An unambiguous reference to the resource within a given context
n/a
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
2003
Antiviral research
Booth T
Docherty J J
Fu M M
Lesniewski M
Pharmacology & Pharmacy
Smith J
Stoner T
Tsai C C
Virology
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1186/1742-4690-3-26" target="_blank" rel="noreferrer noopener">http://doi.org/10.1186/1742-4690-3-26</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
19-19
Volume
3
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Dublin Core
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Title
A name given to the resource
Gene Expression Profiling Of Microglia Infected By A Highly Neurovirulent Murine Leukemia Virus: Implications For Neuropathogenesis
Publisher
An entity responsible for making the resource available
Retrovirology
Date
A point or period of time associated with an event in the lifecycle of the resource
2006
2006-05
Subject
The topic of the resource
arrays; cells; central-nervous-system; endoplasmic-reticulum stress; env gene; envelope protein; induced spongiform neurodegeneration; mice; motor neuron disease; oligonucleotide; retrovirus; Virology
Creator
An entity primarily responsible for making the resource
Dimcheff D E; Volkert L G; Li Y; DeLucia A L; Lynch W P
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1186/1742-4690-3-26" target="_blank" rel="noreferrer noopener">10.1186/1742-4690-3-26</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
2006
arrays
Cells
central-nervous-system
DeLucia A L
Dimcheff D E
endoplasmic-reticulum stress
env gene
envelope protein
induced spongiform neurodegeneration
Li Y
Lynch W P
Mice
motor neuron disease
oligonucleotide
Retrovirology
retrovirus
Virology
Volkert L G
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0166-3542(86)90008-2" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0166-3542(86)90008-2</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
137-149
Issue
3
Volume
6
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Title
A name given to the resource
2-DEOXY-D-GLUCOSE INHIBITION OF HERPES-SIMPLEX VIRUS TYPE-1 RECEPTOR EXPRESSION
Publisher
An entity responsible for making the resource available
Antiviral Research
Date
A point or period of time associated with an event in the lifecycle of the resource
1986
1986-05
Subject
The topic of the resource
Pharmacology & Pharmacy; Virology
Creator
An entity primarily responsible for making the resource
Mohanty J G; Rosenthal K S
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0166-3542(86)90008-2" target="_blank" rel="noreferrer noopener">10.1016/0166-3542(86)90008-2</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
1986
Antiviral research
Journal Article or Conference Abstract Publication
Mohanty J G
Pharmacology & Pharmacy
Rosenthal K S
Virology
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1159/000150141" target="_blank" rel="noreferrer noopener">http://doi.org/10.1159/000150141</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
76-84
Issue
2
Volume
31
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Title
A name given to the resource
NUCLEOCAPSID, NUCLEAR-ASSOCIATION, AND GENOME LOCATION OF THE HERPES-SIMPLEX VIRUS TYPE-2 38-KD DNA-BINDING PROTEIN
Publisher
An entity responsible for making the resource available
Intervirology
Date
A point or period of time associated with an event in the lifecycle of the resource
1990
1990-03
Subject
The topic of the resource
Virology
Creator
An entity primarily responsible for making the resource
Burdett L A; Docherty J J; Howett M K
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1159/000150141" target="_blank" rel="noreferrer noopener">10.1159/000150141</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
1990
Burdett L A
Docherty J J
Howett M K
Intervirology
Journal Article or Conference Abstract Publication
Virology
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
n/a
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
95-95
Issue
1
Volume
9
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Dublin Core
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Title
A name given to the resource
INHIBITION OF PHOSPHORYLATION AND VIRAL PROTEIN-KINASE ACTIVITY BY D609 (TRICYCLODECAN-9-YL-XANTHOGENATE)
Publisher
An entity responsible for making the resource available
Antiviral Research
Date
A point or period of time associated with an event in the lifecycle of the resource
1988
1988-01
Subject
The topic of the resource
Pharmacology & Pharmacy; Virology
Creator
An entity primarily responsible for making the resource
Walro D G; Rosenthal K S
Identifier
An unambiguous reference to the resource within a given context
n/a
Format
The file format, physical medium, or dimensions of the resource
Journal Article
1988
Antiviral research
Journal Article
Pharmacology & Pharmacy
Rosenthal K S
Virology
Walro D G
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
n/a
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
A66-A66
Issue
3
Volume
57
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Title
A name given to the resource
In vivo and in vitro antiherpetic effects of hydroxytolans
Publisher
An entity responsible for making the resource available
Antiviral Research
Date
A point or period of time associated with an event in the lifecycle of the resource
2003
2003-02
Subject
The topic of the resource
Pharmacology & Pharmacy; Virology
Creator
An entity primarily responsible for making the resource
Tsai C C; Lesniewski M L; Liu B; Parakulam R R; Fu M M; Docherty J J
Identifier
An unambiguous reference to the resource within a given context
n/a
Format
The file format, physical medium, or dimensions of the resource
Journal Article
2003
Antiviral research
Docherty J J
Fu M M
Journal Article
Lesniewski M L
Liu B
Parakulam R R
Pharmacology & Pharmacy
Tsai C C
Virology
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
n/a
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
93-93
Issue
1
Volume
9
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Dublin Core
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Title
A name given to the resource
INVITRO ANTIVIRAL ACTIVITY STUDIES OF POLY-R(A-U) AND INTERCALATING AGENTS
Publisher
An entity responsible for making the resource available
Antiviral Research
Date
A point or period of time associated with an event in the lifecycle of the resource
1988
1988-01
Subject
The topic of the resource
Pharmacology & Pharmacy; Virology
Creator
An entity primarily responsible for making the resource
Tsai C C; Jamison J M; Flowers D G; Kitareewan S
Identifier
An unambiguous reference to the resource within a given context
n/a
Format
The file format, physical medium, or dimensions of the resource
Journal Article
1988
Antiviral research
Flowers D G
Jamison J M
Journal Article
Kitareewan S
Pharmacology & Pharmacy
Tsai C C
Virology
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
n/a
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
S80-S80
Volume
24
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Dublin Core
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Title
A name given to the resource
PARALYTIC RETROVIRUS-INDUCED SPONGIFORM NEURODEGENERATION IS PHYSIOLOGICALLY CHARACTERIZED BY GLIAL-MEDIATED MOTOR NEURON DEPOLARIZATION BLOCK
Publisher
An entity responsible for making the resource available
Journal of Neurovirology
Date
A point or period of time associated with an event in the lifecycle of the resource
2018
2018-04
Subject
The topic of the resource
Neurosciences & Neurology; Virology
Creator
An entity primarily responsible for making the resource
Sivaramakrishnan S; Lynch W
Identifier
An unambiguous reference to the resource within a given context
n/a
Format
The file format, physical medium, or dimensions of the resource
Journal Article
2018
Journal Article
Journal of neurovirology
Lynch W
Neurosciences & Neurology
Sivaramakrishnan S
Virology
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
n/a
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
A65-A65
Issue
3
Volume
57
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Title
A name given to the resource
An immunomodulating peptide (CEL-1000) elicits protection against HSV-1
Publisher
An entity responsible for making the resource available
Antiviral Research
Date
A point or period of time associated with an event in the lifecycle of the resource
2003
2003-02
Subject
The topic of the resource
Pharmacology & Pharmacy; Virology
Creator
An entity primarily responsible for making the resource
Rosenthal K S; Goel N; Zimmerman D H
Identifier
An unambiguous reference to the resource within a given context
n/a
Format
The file format, physical medium, or dimensions of the resource
Journal Article
2003
Antiviral research
Goel N
Journal Article
Pharmacology & Pharmacy
Rosenthal K S
Virology
Zimmerman D H
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
n/a
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
980-983
Issue
3
Volume
49
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Title
A name given to the resource
HERPES-SIMPLEX VIRUS BINDING AND ENTRY MODULATE CELL-SURFACE PROTEIN MOBILITY
Publisher
An entity responsible for making the resource available
Journal of Virology
Date
A point or period of time associated with an event in the lifecycle of the resource
1984
1984
Subject
The topic of the resource
Virology
Creator
An entity primarily responsible for making the resource
Rosenthal K S; Leuther M D; Barisas B G
Identifier
An unambiguous reference to the resource within a given context
n/a
Format
The file format, physical medium, or dimensions of the resource
Journal Article
1984
Barisas B G
Journal Article
Journal of virology
Leuther M D
Rosenthal K S
Virology
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
n/a
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
A45-A45
Issue
1
Volume
46
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Title
A name given to the resource
The activity of Mg2+ and poly r(A-U) against HIV-I
Publisher
An entity responsible for making the resource available
Antiviral Research
Date
A point or period of time associated with an event in the lifecycle of the resource
2000
2000-04
Subject
The topic of the resource
Pharmacology & Pharmacy; Virology
Creator
An entity primarily responsible for making the resource
Nassiri M R; Jamison J M; Gilloteaux J; Tsai C C; Summers J L
Identifier
An unambiguous reference to the resource within a given context
n/a
Format
The file format, physical medium, or dimensions of the resource
Journal Article
2000
Antiviral research
Gilloteaux J
Jamison J M
Journal Article
Nassiri M R
Pharmacology & Pharmacy
Summers J L
Tsai C C
Virology
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/s0166-3542(97)00040-5" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/s0166-3542(97)00040-5</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
63-72
Issue
1
Volume
36
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Dublin Core
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Title
A name given to the resource
The antiviral xanthate compound D609 inhibits herpes simplex virus type 1 replication and protein phosphorylation
Publisher
An entity responsible for making the resource available
Antiviral Research
Date
A point or period of time associated with an event in the lifecycle of the resource
1997
1997-09
Subject
The topic of the resource
antiviral drug; cells; culture; D609; gene; growth; HSV-1; identification; interruption; kinase; Pharmacology & Pharmacy; phosphorylation; protein; protein-kinase; pseudorabies virus; purification; us3; US3 PK; Virology
Creator
An entity primarily responsible for making the resource
Walro D G; Rosenthal K S
Description
An account of the resource
The mechanism of antiviral action of tricyclodecan-9-yl-xanthogenate (D609) was investigated in vitro. D609 inhibited herpes simplex virus type 1 (HSV-1) replication without apparent cytotoxicity. It reduced phosphorylation of virus-infected cell polypeptides and inhibited the HSV-1 encoded protein kinase (US3 PK) and, to a lesser extent, cellular protein kinase C in vitro. Virus production was reduced by D609 at concentrations greater than 3.8 mu M, With complete inhibition at 75.2 mu M at an MOI of 1 PFU/cell or less. Addition of D609 could be delayed until 7 h post-infection and still inhibit virus replication. Phosphorylation of infected cell viral polypeptides of 34 (similar molecular weight to the substrate of the viral US3 protein kinase) and 69 kDa was inhibited at 18.4 mu M Treatment of infected or uninfected cells with 37.6 mu M D609 reduced protein phosphorylation to background levels. A concentration of 1.9 mu M D609 in vitro inhibited the viral US3-encoded PK, which had been purified from infected cell lysates by affinity chromatography and identified by specific antibody. Purified cellular protein kinase C was inhibited at 75.2 mu M D609 whereas other cellular kinases including casein kinase 1 and cAMP dependent kinase were not inhibited at concentrations as high as 188 mu M D609. Collectively these data indicate that the mechanism of antiviral action of D609 is by inhibition of protein kinases and protein phosphorylation affecting a late step in HSV replication. (C) 1997 Elsevier Science B.V.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/s0166-3542(97)00040-5" target="_blank" rel="noreferrer noopener">10.1016/s0166-3542(97)00040-5</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article
1997
antiviral drug
Antiviral research
Cells
Culture
D609
gene
growth
HSV-1
identification
interruption
Journal Article
Kinase
Pharmacology & Pharmacy
Phosphorylation
Protein
protein-kinase
pseudorabies virus
purification
Rosenthal K S
us3
US3 PK
Virology
Walro D G
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1099/0022-1317-66-7-1601" target="_blank" rel="noreferrer noopener">http://doi.org/10.1099/0022-1317-66-7-1601</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
1601-1605
Volume
66
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Title
A name given to the resource
INHIBITION OF HERPES-SIMPLEX VIRUS TYPE-1 PENETRATION BY CYTOCHALASIN-B AND CYTOCHALASIN-D
Publisher
An entity responsible for making the resource available
Journal of General Virology
Date
A point or period of time associated with an event in the lifecycle of the resource
1985
1985
Subject
The topic of the resource
Biotechnology & Applied Microbiology; Virology
Creator
An entity primarily responsible for making the resource
Rosenthal K S; Perez R; Hodnichak C
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1099/0022-1317-66-7-1601" target="_blank" rel="noreferrer noopener">10.1099/0022-1317-66-7-1601</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article
1985
Biotechnology & Applied Microbiology
Hodnichak C
Journal Article
Journal of General Virology
Perez R
Rosenthal K S
Virology
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1006/viro.1998.9240" target="_blank" rel="noreferrer noopener">http://doi.org/10.1006/viro.1998.9240</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
127-136
Issue
2
Volume
247
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Title
A name given to the resource
Dissecting the determinants of neuropathogenesis of the murine oncornaviruses
Publisher
An entity responsible for making the resource available
Virology
Date
A point or period of time associated with an event in the lifecycle of the resource
1998
1998-08
Subject
The topic of the resource
c rna virus; central-nervous-system; endothelial-cell tropism; induced spongiform; infection; leukemia-virus; motor neuron disease; neurodegeneration; neurological disease; neurotropic retrovirus; temperature-sensitive mutant; Virology; wild mouse retrovirus
Creator
An entity primarily responsible for making the resource
Portis J L; Lynch W P
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1006/viro.1998.9240" target="_blank" rel="noreferrer noopener">10.1006/viro.1998.9240</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article
1998
c rna virus
central-nervous-system
endothelial-cell tropism
induced spongiform
Infection
Journal Article
leukemia-virus
Lynch W P
motor neuron disease
Neurodegeneration
neurological disease
neurotropic retrovirus
Portis J L
temperature-sensitive mutant
Virology
wild mouse retrovirus
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0042-6822(92)90093-5" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0042-6822(92)90093-5</a>
Pages
339–341
Issue
1
Volume
186
Dublin Core
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Title
A name given to the resource
Differences in the integration pattern and episomal forms of human papillomavirus type 16 DNA found within an invasive cervical neoplasm and its metastasis.
Publisher
An entity responsible for making the resource available
Virology
Date
A point or period of time associated with an event in the lifecycle of the resource
1992
1992-01
Subject
The topic of the resource
Carcinoma; DNA; Electrophoresis; Female; Gel; Humans; Neoplasm Metastasis; Papillomaviridae/*genetics; Plasmids; Squamous Cell/*microbiology/pathology; Two-Dimensional; Uterine Cervical Neoplasms/*microbiology/pathology; Vaginal Neoplasms/microbiology/pathology/secondary; Viral/analysis; Virus Integration
Creator
An entity primarily responsible for making the resource
Galehouse D; Jenison E; DeLucia A
Description
An account of the resource
Human papillomavirus (HPV) type 16 DNA was found in three separate neoplastic lesions within a female patient. The physical state of the viral DNA in each lesion was determined by two-dimensional agarose gel electrophoresis. The primary cervical tumor contained large amounts of several distinct episomal forms as well as integrated HPV DNA. Metastatic tumor tissue found in the vagina had greatly reduced levels of episomal DNA and a viral DNA integration pattern that was different from that of the primary tumor. The vulvar carcinoma in situ had what appears to be free and integrated forms of viral DNA. The results show that although metastatic tissue retained HPV DNA, further rearrangements of the integrated viral DNA pattern found in the primary tumor may occur with a dramatic decrease of episomal forms during malignant progression.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0042-6822(92)90093-5" target="_blank" rel="noreferrer noopener">10.1016/0042-6822(92)90093-5</a>
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Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1992
Carcinoma
DeLucia A
Department of Integrative Medical Sciences
DNA
Electrophoresis
Female
Galehouse D
Gel
Humans
Jenison E
NEOMED College of Medicine
Neoplasm Metastasis
Papillomaviridae/*genetics
Plasmids
Squamous Cell/*microbiology/pathology
Two-Dimensional
Uterine Cervical Neoplasms/*microbiology/pathology
Vaginal Neoplasms/microbiology/pathology/secondary
Viral/analysis
Virology
Virus Integration
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1006/viro.2001.1299" target="_blank" rel="noreferrer noopener">http://doi.org/10.1006/viro.2001.1299</a>
Pages
262–272
Issue
2
Volume
293
Dublin Core
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Title
A name given to the resource
Reexamination of amphotropic murine leukemia virus neurovirulence: neural stem cell-mediated microglial infection fails to induce acute neurodegeneration.
Publisher
An entity responsible for making the resource available
Virology
Date
A point or period of time associated with an event in the lifecycle of the resource
2002
2002-02
Subject
The topic of the resource
*Leukemia Virus; *Reassortant Viruses/pathogenicity; Animals; Cell Line; Central Nervous System Diseases/*pathology/virology; Experimental/*pathology; Friend murine leukemia virus/genetics/pathogenicity; Leukemia; Mice; Microglia/pathology/virology; Murine/isolation & purification/pathogenicity; Newborn; Retroviridae Infections/*pathology; Tumor Virus Infections/*pathology; Viral Envelope Proteins/genetics/isolation & purification; Viremia; Virulence
Creator
An entity primarily responsible for making the resource
Traister Russell S; Lynch William P
Description
An account of the resource
The 4070A amphotropic murine leukemia virus (A-MuLV) has been variably reported to harbor neurovirulence determinants within its env gene. In this report we reexamined this issue by applying two approaches previously demonstrated to amplify murine leukemia virus neurovirulence. The first approach involved introducing the 4070A env gene into the background of Friend virus clone FB29 to enhance peripheral virus replication kinetics and central nervous system entry. The resulting chimeric virus, FrAmE, exhibited widespread vascular infection throughout the central nervous system (CNS); however, parenchymal infection was quite limited. Neither clinical neurological signs nor spongiform neurological changes accompanied FrAmE CNS infection. To overcome this CNS entry limitation, 4070A and FrAmE were delivered directly into the CNS via transplantation of infected C17.2 neural stem cells (NSCs). Significantly, NSC dissemination of either 4070A or FrAmE resulted in widespread, high-level amphotropic virus expression within the CNS parenchyma, including the infection of microglia, the critical target required for inducing neurodegeneration. Despite the extensive CNS infection, no associated clinical neurological signs or acute neuropathological changes were observed. Interestingly, we observed the frequent appearance of circulating polytropic (MCF) virus in the serum of amphotropic virus-infected animals. However, neither peripheral inoculation of an amphotropic/MCF virus mixture nor transplantation of NSCs expressing both amphotropic and MCF viruses induced acute clinical neurological signs or spongiform neuropathology. Thus, the results generated in this study suggest that the 4070A env gene is not inherently neurovirulent. However, the frequent appearance of endogenous MCF viruses suggests the possibility that the interactions of amphotropic viruses with endogenous retroviral elements could contribute to the development of retrovirus-induced neurodegenerative disease.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1006/viro.2001.1299" target="_blank" rel="noreferrer noopener">10.1006/viro.2001.1299</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Leukemia Virus
*Reassortant Viruses/pathogenicity
2002
Animals
Cell Line
Central Nervous System Diseases/*pathology/virology
Department of Integrative Medical Sciences
Experimental/*pathology
Friend murine leukemia virus/genetics/pathogenicity
Leukemia
Lynch William P
Mice
Microglia/pathology/virology
Murine/isolation & purification/pathogenicity
NEOMED College of Medicine
Newborn
Retroviridae Infections/*pathology
Traister Russell S
Tumor Virus Infections/*pathology
Viral Envelope Proteins/genetics/isolation & purification
Viremia
Virology
Virulence
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1006/viro.2000.0338" target="_blank" rel="noreferrer noopener">http://doi.org/10.1006/viro.2000.0338</a>
Pages
227–233
Issue
2
Volume
271
Dublin Core
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Title
A name given to the resource
Neural stem cells as tools for understanding retroviral neuropathogenesis.
Publisher
An entity responsible for making the resource available
Virology
Date
A point or period of time associated with an event in the lifecycle of the resource
2000
2000-06
Subject
The topic of the resource
Animals; Humans; Membrane Fusion/physiology; Microglia/virology; Neurons/*virology; Retroviridae Infections/virology; Retroviridae Proteins/metabolism; Retroviridae/*pathogenicity; Stem Cells/*virology; Viral Envelope Proteins/metabolism; Virulence
Creator
An entity primarily responsible for making the resource
Lynch W P; Portis J L
Description
An account of the resource
The discovery within the past decade that neural stem cells (NSCs) from the developing and adult mammalian brain can be propagated, cloned, and genetically manipulated ex vivo for ultimate transfer back into the CNS has opened the door to a novel means for modifying the CNS environment for experimental and therapeutic purposes. While a great deal of interest has been focused on the properties and promise of this new technology, especially in regard to cellular replacement and gene therapy, this minireview will focus on the recent use of NSCs to study the neuropathogenesis of the murine oncornaviruses. In brief, the use of this NSC-based approach has provided a means for selective reconstitution within the brain, of specific retroviral life cycle events, in order to consider their contribution to the induction of neurodegeneration. Furthermore, by virtue of their ability to disseminate virus within the brain, NSCs have provided a reliable means for assessing the true neurovirulence potential of murine oncornaviruses by directly circumventing a restriction to virus entry into the CNS. Importantly, these experiments have demonstrated that the neurovirulence of oncornaviruses requires late virus life cycle events occurring specifically within microglia, the resident macrophages of the brain. This initial application of NSC biology to the analysis of oncornavirus-CNS interactions may serve as an example for how other questions in viral neuropathogenesis might be addressed in the future.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1006/viro.2000.0338" target="_blank" rel="noreferrer noopener">10.1006/viro.2000.0338</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2000
Animals
Humans
Lynch W P
Membrane Fusion/physiology
Microglia/virology
Neurons/*virology
Portis J L
Retroviridae Infections/virology
Retroviridae Proteins/metabolism
Retroviridae/*pathogenicity
Stem Cells/*virology
Viral Envelope Proteins/metabolism
Virology
Virulence