1
40
3
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Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
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<table width="91" style="border-collapse:collapse;width:68pt;"><colgroup><col width="91" style="width:68pt;" /></colgroup><tbody><tr style="height:15pt;"><td width="91" height="20" class="xl18" style="width:68pt;height:15pt;"><a href="http://doi.org/10.1111/jtxs.12599">http://doi.org/10.1111/jtxs.12599</a></td>
</tr></tbody></table>
NEOMED College
NEOMED College of Medicine
NEOMED Department
Department of Anatomy & Neurobiology
Update Year & Number
Jan to Aug list 2021
Dublin Core
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Title
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Increased viscosity of milk during infant feeding improves swallow safety through modifying sucking in an animal model.
Creator
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Mayerl CJ; Edmonds CE; Gould FDH; German RZ
Publisher
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Journal Of Texture Studies
Date
A point or period of time associated with an event in the lifecycle of the resource
2021
2021-03-30
Description
An account of the resource
Infants experiencing frequent aspiration, the entry of milk into the airway, are often prescribed thickened fluids to improve swallow safety. However, research on the outcomes of thickened milk on infant feeding have been limited to documenting rates of aspiration and the rheologic properties of milk following thickening. As a result, we have little insight into the physiologic and behavioral mechanisms driving differences in performance during feeding on high viscosity milk. Understanding the physiologic and behavioral mechanisms driving variation in performance at different viscosities is especially critical, because the structures involved in feeding respond differently to sensory stimulation. We used infant pigs, a validated animal model for infant feeding, to test how the tongue, soft palate, and hyoid respond to changes in viscosity during sucking and swallowing, in addition to measuring swallow safety and bolus size. We found that the tongue exhibited substantive changes in its movements associated with thickened fluids during sucking and swallowing, but that pharyngeal transit time as well as hyoid and soft palate movements during swallowing were unaffected. This work demonstrates the integrated nature of infant feeding and that behaviors associated with sucking are more sensitive to sensorimotor feedback associated with changes in milk viscosity than those associated with the pharyngeal swallow, likely due to its reflexive nature.
Subject
The topic of the resource
Aspiration, the entry of food or liquid into the airway, is especially prevalent in infant mammals relative to adults (Jadcherla, 2016; Stricklen, Bond, Gould, German, & Mayerl, 2020). High rates of aspiration can have detrimental health impacts, and in the most extreme cases result in aspiration pneumonia and death (Logemann, 2007; Prasse & Kikano, 2009). One of the most commonly accepted methods of reducing the occurrence of aspiration in infants is increasing the viscosity of ingested material (Cichero, Nicholson, & September, 2013; Newman, Vilardell, Clavé, & Speyer, 2016). The clinical outcomes of increased viscosity in infants are fairly well understood, and include reduced occurrence of regurgitation and aspiration, and increased weight gain (Krummrich, Kline, Krival, & Rubin, 2017; Salvatore et al., 2018). However, most research on the impact of viscosity on infant feeding has focused on the rheologic properties of the liquid, and how time, temperature, and thickening agent impact viscosity (Gosa & Dodrill, 2017; September, Nicholson, & Cichero, 2014; Yoon & Yoo, 2017). As a result, we have very little insight into the physiologic mechanisms driving differences in performance due to changes in viscosity.
Identifier
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<table width="91" style="border-collapse:collapse;width:68pt;"><colgroup><col width="91" style="width:68pt;" /></colgroup><tbody><tr style="height:15pt;"><td width="91" height="20" class="xl18" style="width:68pt;height:15pt;"><a href="http://doi.org/10.1111/jtxs.12599">http://doi.org/10.1111/jtxs.12599</a></td>
</tr></tbody></table>
Format
The file format, physical medium, or dimensions of the resource
Journal Article
2021
Animal model
Dysphagia
Infant
Physiology
suckling
Viscosity
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1111/jtxs.12599" target="_blank" rel="noreferrer noopener">http://doi.org/10.1111/jtxs.12599</a>
ISSN
1745-4603 0022-4901
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Update Year & Number
April 2021 List
NEOMED College
NEOMED College of Medicine
NEOMED Department
Department of Anatomy & Neurobiology
NEOMED Postdoc Publications
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Increased viscosity of milk during infant feeding improves swallow safety through modifying sucking in an animal model.
Publisher
An entity responsible for making the resource available
Journal Of Texture Studies
Date
A point or period of time associated with an event in the lifecycle of the resource
2021
2021-03-30
Subject
The topic of the resource
physiology; dysphagia; infant; animal model; suckling; viscosity
Creator
An entity primarily responsible for making the resource
Mayerl CJ; Edmonds CE; Gould FDH; German RZ
Description
An account of the resource
Infants experiencing frequent aspiration, the entry of milk into the airway, are often prescribed thickened fluids to improve swallow safety. However, research on the outcomes of thickened milk on infant feeding have been limited to documenting rates of aspiration and the rheologic properties of milk following thickening. As a result, we have little insight into the physiologic and behavioral mechanisms driving differences in performance during feeding on high viscosity milk. Understanding the physiologic and behavioral mechanisms driving variation in performance at different viscosities is especially critical, because the structures involved in feeding respond differently to sensory stimulation. We used infant pigs, a validated animal model for infant feeding, to test how the tongue, soft palate, and hyoid respond to changes in viscosity during sucking and swallowing, in addition to measuring swallow safety and bolus size. We found that the tongue exhibited substantive changes in its movements associated with thickened fluids during sucking and swallowing, but that pharyngeal transit time as well as hyoid and soft palate movements during swallowing were unaffected. This work demonstrates the integrated nature of infant feeding and that behaviors associated with sucking are more sensitive to sensorimotor feedback associated with changes in milk viscosity than those associated with the pharyngeal swallow, likely due to its reflexive nature.
Identifier
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<a href="http://doi.org/10.1111/jtxs.12599" target="_blank" rel="noreferrer noopener">10.1111/jtxs.12599</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Format
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journalArticle
2021
Animal model
April 2021 List
Department of Anatomy & Neurobiology
Dysphagia
Edmonds CE
German RZ
Gould FDH
Infant
Journal of Texture Studies
journalArticle
Mayerl CJ
NEOMED College of Medicine
NEOMED Postdoc Publications
Physiology
suckling
Viscosity
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.3109/10837450.2011.647035" target="_blank" rel="noreferrer noopener">http://doi.org/10.3109/10837450.2011.647035</a>
Pages
957–962
Issue
4
Volume
18
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
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Thermoreversible gel for delivery of activin receptor-like kinase 5 inhibitor
Publisher
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Pharmaceutical development and technology
Date
A point or period of time associated with an event in the lifecycle of the resource
2013
2013-08
Subject
The topic of the resource
Time Factors; Animals; Body Temperature; *Drug Delivery Systems; Temperature; Rabbits; Benzodioxoles/*administration & dosage/pharmacokinetics/toxicity; Delayed-Action Preparations; Drug Carriers/chemistry/toxicity; Fibroblasts/drug effects/metabolism; Filtering Surgery/*methods; Gels; Glaucoma/*surgery; Imidazoles/*administration & dosage/pharmacokinetics/toxicity; Poloxamer/chemistry/toxicity; Protein-Serine-Threonine Kinases/antagonists & inhibitors; Pyridines/*administration & dosage/pharmacokinetics/toxicity; Viscosity; Receptors; Receptor; Animal; Disease Models; Transforming Growth Factor-beta Type I; Transforming Growth Factor beta/antagonists & inhibitors
Creator
An entity primarily responsible for making the resource
Sutariya Vijaykumar; Miladore Nicholas; Geldenhuys Werner; Bhatia Deepak; Wehrung Daniel; Nakamura Hiroshi
Description
An account of the resource
The purpose of this study is to investigate a thermoreversible gel using Pluronic
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.3109/10837450.2011.647035" target="_blank" rel="noreferrer noopener">10.3109/10837450.2011.647035</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Drug Delivery Systems
2013
Animal
Animals
Benzodioxoles/*administration & dosage/pharmacokinetics/toxicity
Bhatia Deepak
Body Temperature
Delayed-Action Preparations
Disease Models
Drug Carriers/chemistry/toxicity
Fibroblasts/drug effects/metabolism
Filtering Surgery/*methods
Geldenhuys Werner
Gels
Glaucoma/*surgery
Imidazoles/*administration & dosage/pharmacokinetics/toxicity
Miladore Nicholas
Nakamura Hiroshi
Pharmaceutical development and technology
Poloxamer/chemistry/toxicity
Protein-Serine-Threonine Kinases/antagonists & inhibitors
Pyridines/*administration & dosage/pharmacokinetics/toxicity
Rabbits
Receptor
Receptors
Sutariya Vijaykumar
Temperature
Time Factors
Transforming Growth Factor beta/antagonists & inhibitors
Transforming Growth Factor-beta Type I
Viscosity
Wehrung Daniel