1
40
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Text
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URL Address
<a href="http://doi.org/10.1016/0006-3223(93)90251-8" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0006-3223(93)90251-8</a>
Pages
13–17
Issue
1
Volume
34
Dublin Core
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Title
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Adverse reactions to aspartame: double-blind challenge in patients from a vulnerable population.
Publisher
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Biological psychiatry
Date
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1993
1993-07
Subject
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Adult; Aspartame/*adverse effects/*therapeutic use; Cross-Sectional Studies; Depressive Disorder/diagnosis/*drug therapy/psychology; Double-Blind Method; Eye Diseases/etiology/physiopathology; Female; Headache/etiology; Humans; Male; Middle Aged; Placebos; Psychiatric Status Rating Scales; Vision Disorders/etiology/physiopathology
Creator
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Walton R G; Hudak R; Green-Waite R J
Description
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This study was designed to ascertain whether individuals with mood disorders are particularly vulnerable to adverse effects of aspartame. Although the protocol required the recruitment of 40 patients with unipolar depression and a similar number of individuals without a psychiatric history, the project was halted by the Institutional Review Board after a total of 13 individuals had completed the study because of the severity of reactions within the group of patients with a history of depression. In a crossover design, subjects received aspartame 30 mg/kg/day or placebo for 7 days. Despite the small n, there was a significant difference between aspartame and placebo in number and severity of symptoms for patients with a history of depression, whereas for individuals without such a history there was not. We conclude that individuals with mood disorders are particularly sensitive to this artificial sweetener and its use in this population should be discouraged.
Identifier
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<a href="http://doi.org/10.1016/0006-3223(93)90251-8" target="_blank" rel="noreferrer noopener">10.1016/0006-3223(93)90251-8</a>
Rights
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1993
Adult
Aspartame/*adverse effects/*therapeutic use
Biological psychiatry
Cross-Sectional Studies
Depressive Disorder/diagnosis/*drug therapy/psychology
Double-Blind Method
Eye Diseases/etiology/physiopathology
Female
Green-Waite R J
Headache/etiology
Hudak R
Humans
Male
Middle Aged
Placebos
Psychiatric Status Rating Scales
Vision Disorders/etiology/physiopathology
Walton R G