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40
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Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1152/jn.00227.2014" target="_blank" rel="noreferrer noopener">http://doi.org/10.1152/jn.00227.2014</a>
Pages
683–704
Issue
3
Volume
112
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Postinhibitory rebound neurons and networks are disrupted in retrovirus-induced spongiform neurodegeneration.
Publisher
An entity responsible for making the resource available
Journal of neurophysiology
Date
A point or period of time associated with an event in the lifecycle of the resource
2014
2014-08
Subject
The topic of the resource
Action Potentials/physiology; Animals; Antigens/metabolism; auditory midbrain; Calcium/metabolism; env/metabolism; Experimental/physiopathology; Gene Products; Hearing Loss/physiopathology; Inferior Colliculi/physiopathology/virology; inferior colliculus; Leukemia; Leukemia Virus; Membrane Potentials/physiology; Mice; Microglia/physiology/virology; Murine/*physiology; Neural Pathways/physiopathology; Neurodegenerative Diseases/*physiopathology; Neuroglia/physiology/virology; Neurons/*physiology/virology; Patch-Clamp Techniques; postinhibitory rebound neurons; Proteoglycans/metabolism; Retroviridae Infections/*physiopathology/virology; retrovirus; Tissue Culture Techniques; Tumor Virus Infections/*physiopathology/virology; Voltage-Sensitive Dye Imaging; voltage-sensitive dyes
Creator
An entity primarily responsible for making the resource
Li Ying; Davey Robert A; Sivaramakrishnan Shobhana; Lynch William P
Description
An account of the resource
Certain retroviruses induce progressive spongiform motor neuron disease with features resembling prion diseases and amyotrophic lateral sclerosis. With the neurovirulent murine leukemia virus (MLV) FrCasE, Env protein expression within glia leads to postsynaptic vacuolation, cellular effacement, and neuronal loss in the absence of neuroinflammation. To understand the physiological changes associated with MLV-induced spongiosis, and its neuronal specificity, we employed patch-clamp recordings and voltage-sensitive dye imaging in brain slices of the mouse inferior colliculus (IC), a midbrain nucleus that undergoes extensive spongiosis. IC neurons characterized by postinhibitory rebound firing (PIR) were selectively affected in FrCasE-infected mice. Coincident with Env expression in microglia and in glia characterized by NG2 proteoglycan expression (NG2 cells), rebound neurons (RNs) lost PIR, became hyperexcitable, and were reduced in number. PIR loss and hyperexcitability were reversed by raising internal calcium buffer concentrations in RNs. PIR-initiated rhythmic circuits were disrupted, and spontaneous synchronized bursting and prolonged depolarizations were widespread. Other IC neuron cell types and circuits within the same degenerative environment were unaffected. Antagonists of NMDA and/or AMPA receptors reduced burst firing in the IC but did not affect prolonged depolarizations. Antagonists of L-type calcium channels abolished both bursts and slow depolarizations. IC infection by the nonneurovirulent isogenic virus Friend 57E (Fr57E), whose Env protein is structurally similar to FrCasE, showed no RN hyperactivity or cell loss; however, PIR latency increased. These findings suggest that spongiform neurodegeneration arises from the unique excitability of RNs, their local regulation by glia, and the disruption of this relationship by glial expression of abnormal protein.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1152/jn.00227.2014" target="_blank" rel="noreferrer noopener">10.1152/jn.00227.2014</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2014
Action Potentials/physiology
Animals
Antigens/metabolism
auditory midbrain
Calcium/metabolism
Davey Robert A
Department of Integrative Medical Sciences
env/metabolism
Experimental/physiopathology
Gene Products
Hearing Loss/physiopathology
Inferior Colliculi/physiopathology/virology
inferior colliculus
Journal of neurophysiology
Leukemia
Leukemia Virus
Li Ying
Lynch William P
Membrane Potentials/physiology
Mice
Microglia/physiology/virology
Murine/*physiology
NEOMED College of Medicine
Neural Pathways/physiopathology
Neurodegenerative Diseases/*physiopathology
Neuroglia/physiology/virology
Neurons/*physiology/virology
Patch-Clamp Techniques
postinhibitory rebound neurons
Proteoglycans/metabolism
Retroviridae Infections/*physiopathology/virology
retrovirus
Sivaramakrishnan Shobhana
Tissue Culture Techniques
Tumor Virus Infections/*physiopathology/virology
Voltage-Sensitive Dye Imaging
voltage-sensitive dyes
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.jneumeth.2017.08.029" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.jneumeth.2017.08.029</a>
Pages
227–237
Volume
291
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
An operant-based detection method for inferring tinnitus in mice.
Publisher
An entity responsible for making the resource available
Journal of neuroscience methods
Date
A point or period of time associated with an event in the lifecycle of the resource
2017
2017-11
Subject
The topic of the resource
*Conditioning; *Disease Models; *Inferior colliculus; *Mouse model; *Noise-induced hearing loss; *Operant conditioning; *Sodium salicylate; *Tinnitus; Acoustic Stimulation; Analysis of Variance; Animal; Animals; Auditory; Avoidance Learning; Brain Stem/physiology; Electroshock; Equipment Design; Evoked Potentials; Female; Inbred C57BL; Inferior Colliculi/physiopathology; Male; Mice; Motor Activity; Neurons/physiology; Operant; Otoacoustic Emissions; Sodium Salicylate; Spontaneous/physiology; Tinnitus/*diagnosis/physiopathology; Tissue Culture Techniques; Voltage-Sensitive Dye Imaging
Creator
An entity primarily responsible for making the resource
Zuo Hongyan; Lei Debin; Sivaramakrishnan Shobhana; Howie Benjamin; Mulvany Jessica; Bao Jianxin
Description
An account of the resource
BACKGROUND: Subjective tinnitus is a hearing disorder in which a person perceives sound when no external sound is present. It can be acute or chronic. Because our current understanding of its pathology is incomplete, no effective cures have yet been established. Mouse models are useful for studying the pathophysiology of tinnitus as well as for developing therapeutic treatments. NEW METHOD: We have developed a new method for determining acute and chronic tinnitus in mice, called sound-based avoidance detection (SBAD). The SBAD method utilizes one paradigm to detect tinnitus and another paradigm to monitor possible confounding factors, such as motor impairment, loss of motivation, and deficits in learning and memory. RESULTS: The SBAD method has succeeded in monitoring both acute and chronic tinnitus in mice. Its detection ability is further validated by functional studies demonstrating an abnormal increase in neuronal activity in the inferior colliculus of mice that had previously been identified as having tinnitus by the SBAD method. COMPARISON WITH EXISTING METHODS: The SBAD method provides a new means by which investigators can detect tinnitus in a single mouse accurately and with more control over potential confounding factors than existing methods. CONCLUSION: This work establishes a new behavioral method for detecting tinnitus in mice. The detection outcome is consistent with functional validation. One key advantage of mouse models is they provide researchers the opportunity to utilize an extensive array of genetic tools. This new method could lead to a deeper understanding of the molecular pathways underlying tinnitus pathology.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/j.jneumeth.2017.08.029" target="_blank" rel="noreferrer noopener">10.1016/j.jneumeth.2017.08.029</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Conditioning
*Disease Models
*Inferior colliculus
*Mouse model
*Noise-induced hearing loss
*Operant conditioning
*Sodium salicylate
*Tinnitus
2017
Acoustic Stimulation
Analysis of Variance
Animal
Animals
Auditory
Avoidance Learning
Bao Jianxin
Brain Stem/physiology
Department of Anatomy & Neurobiology
Electroshock
Equipment Design
Evoked Potentials
Female
Howie Benjamin
Inbred C57BL
Inferior Colliculi/physiopathology
Journal of neuroscience methods
Lei Debin
Male
Mice
Motor Activity
Mulvany Jessica
NEOMED College of Medicine
Neurons/physiology
Operant
Otoacoustic Emissions
Sivaramakrishnan Shobhana
Sodium Salicylate
Spontaneous/physiology
Tinnitus/*diagnosis/physiopathology
Tissue Culture Techniques
Voltage-Sensitive Dye Imaging
Zuo Hongyan