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40
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Text
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URL Address
<a href="http://doi.org/10.3389/fped.2018.00306" target="_blank" rel="noreferrer noopener">http://doi.org/10.3389/fped.2018.00306</a>
Pages
306–306
Volume
6
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
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Fluid Overload in Critically Ill Children.
Publisher
An entity responsible for making the resource available
Frontiers in pediatrics
Date
A point or period of time associated with an event in the lifecycle of the resource
2018
1905-07
Subject
The topic of the resource
acute kidney injury; critical care; fluid overload; intensive care; pediatric nephrology
Creator
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Raina Rupesh; Sethi Sidharth Kumar; Wadhwani Nikita; Vemuganti Meghana; Krishnappa Vinod; Bansal Shyam B
Description
An account of the resource
Background: A common practice in the management of critically ill patients is fluid resuscitation. An excessive administration of fluids can lead to an imbalance in fluid homeostasis and cause fluid overload (FO). In pediatric critical care patients, FO can lead to a multitude of adverse effects and increased risk of morbidity. Objectives: To review the literature highlighting impact of FO on a multitude of outcomes in critically-ill children, causative vs. associative relationship of FO with critical illness and current pediatric fluid management guidelines. Data Sources: A literature search was conducted using PubMed/Medline and Embase databases from the earliest available date until June 2017. Data Extraction: Two authors independently reviewed the titles and abstracts of all articles which were assessed for inclusion. The manuscripts of studies deemed relevant to the objectives of this review were then retrieved and associated reference lists hand-searched. Data Synthesis: Articles were segregated into various categories namely pathophysiology and sequelae of fluid overload, assessment techniques, epidemiology and fluid management. Each author reviewed the selected articles in categories assigned to them. All authors participated in the final review process. Conclusions: Recent evidence has purported a relationship between mortality and FO, which can be validated by prospective RCTs (randomized controlled trials). The current literature demonstrates that "clinically significant" degree of FO could be below 10%. The lack of a standardized method to assess FB (fluid balance) and a universal definition of FO are issues that need to be addressed. To date, the impact of early goal directed therapy and utility of hemodynamic parameters in predicting fluid responsiveness remains underexplored in pediatric resuscitation.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.3389/fped.2018.00306" target="_blank" rel="noreferrer noopener">10.3389/fped.2018.00306</a>
Rights
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2018
Acute kidney injury
Bansal Shyam B
Critical Care
Department of Internal Medicine
fluid overload
Frontiers in pediatrics
intensive care
Krishnappa Vinod
NEOMED College of Graduate Studies Student
NEOMED College of Medicine
pediatric nephrology
Raina Rupesh
Sethi Sidharth Kumar
Vemuganti Meghana
Wadhwani Nikita
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1371/journal.pone.0195536" target="_blank" rel="noreferrer noopener">http://doi.org/10.1371/journal.pone.0195536</a>
Pages
e0195536–e0195536
Issue
4
Volume
13
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Heparin free dialysis in critically sick children using sustained low efficiency dialysis (SLEDD-f): A new hybrid therapy for dialysis in developing world.
Publisher
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PloS one
Date
A point or period of time associated with an event in the lifecycle of the resource
2018
1905-07
Subject
The topic of the resource
Humans; Adolescent; Retrospective Studies; Child; Infant; *Critical Care/methods; Acute Kidney Injury/blood/mortality/*therapy; Critical Illness/*therapy; Developing Countries; Feasibility Studies; Follow-Up Studies; Length of Stay; Renal Dialysis/adverse effects/instrumentation/*methods; Treatment Outcome; Preschool
Creator
An entity primarily responsible for making the resource
Sethi Sidharth Kumar; Bansal Shyam B; Khare Anshika; Dhaliwal Maninder; Raghunathan Veena; Wadhwani Nikita; Nandwani Ashish; Yadav Dinesh Kumar; Mahapatra Amit Kumar; Raina Rupesh
Description
An account of the resource
BACKGROUND: In critically sick adults, sustained low efficiency dialysis [SLED] appears to be better tolerated hemodynamically and outcomes seem to be comparable to CRRT. However, there is paucity of data in critically sick children. In children, two recent studies from Taiwan (n = 11) and India (n = 68) showed benefits of SLED in critically sick children. AIMS AND OBJECTIVES: The objective of the study was to look at the feasibility and tolerability of sustained low efficiency daily dialysis-filtration [SLEDD-f] in critically sick pediatric patients. MATERIAL AND METHODS: Design: Retrospective study Inclusion criteria: All pediatric patients who had undergone heparin free SLEDD-f from January 2012 to October 2017. Measurements: Data collected included demographic details, vital signs, PRISM III at admission, ventilator parameters (where applicable), number of inotropes, blood gas and electrolytes before, during, and on conclusion of SLED therapy. Technical information was gathered regarding SLEDD-f prescription and complications. RESULTS: Between 2012-2017, a total of 242 sessions of SLEDD-f were performed on 70 patients, out of which 40 children survived. The median age of patients in years was 12 (range 0.8-17 years), and the median weight was 39 kg (range 8.5-66 kg). The mean PRISM score at admission was 8.77+/-7.22. SLEDD-f sessions were well tolerated, with marked improvement in fluid status and acidosis. Premature terminations had to be done in 23 (9.5%) of the sessions. There were 21 sessions (8.6%) terminated due to hypotension and 2 sessions (0.8%) terminated due to circuit clotting. Post- SLEDD-f hypocalcemia occurred in 15 sessions (6.2%), post- SLEDD-f hypophosphatemia occurred in 1 session (0.4%), and post- SLEDD-f hypokalemia occurred in 17 sessions (7.0%). CONCLUSIONS: This study is the largest compiled data on pediatric SLEDD-f use in critically ill patients. Our study confirms the feasibility of heparin free SLEDD-f in a larger pediatric population, and even in children weighing \textless20 kg on inotropic support.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1371/journal.pone.0195536" target="_blank" rel="noreferrer noopener">10.1371/journal.pone.0195536</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Critical Care/methods
2018
Acute Kidney Injury/blood/mortality/*therapy
Adolescent
Bansal Shyam B
Child
Critical Illness/*therapy
Department of Internal Medicine
Developing Countries
Dhaliwal Maninder
Feasibility Studies
Follow-Up Studies
Humans
Infant
Khare Anshika
Length of Stay
Mahapatra Amit Kumar
Nandwani Ashish
NEOMED College of Medicine
PloS one
Preschool
Raghunathan Veena
Raina Rupesh
Renal Dialysis/adverse effects/instrumentation/*methods
Retrospective Studies
Sethi Sidharth Kumar
Treatment Outcome
Wadhwani Nikita
Yadav Dinesh Kumar