1 40 4 Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. URL Address n/a Rights Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s). Pages 2-2 Issue 7 Volume 56 Search for Full-text Locate full-text within NEOMED Library's e-journal collections <p>Users with a NEOMED Library login can search for full-text journal articles at the following url: <a href="https://libraryguides.neomed.edu/home">https://libraryguides.neomed.edu/home</a></p> Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Characterization of cytokine levels in the DBA/2J mouse model of glaucoma Publisher An entity responsible for making the resource available Investigative Ophthalmology & Visual Science Date A point or period of time associated with an event in the lifecycle of the resource 2015 2015-06 Subject The topic of the resource Ophthalmology Creator An entity primarily responsible for making the resource Wilson G N; Smith M A; Dengler-Crish C; Inman D M; Crish S D Identifier An unambiguous reference to the resource within a given context n/a Format The file format, physical medium, or dimensions of the resource Journal Article 2015 Crish S D Dengler-Crish C Department of Pharmaceutical Sciences Inman D M Investigative ophthalmology & visual science Journal Article NEOMED College of Pharmacy Ophthalmology Smith M A Wilson G N Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. URL Address n/a Rights Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s). Pages 2-2 Issue 12 Volume 57 Search for Full-text Locate full-text within NEOMED Library's e-journal collections <p>Users with a NEOMED Library login can search for full-text journal articles at the following url: <a href="https://libraryguides.neomed.edu/home">https://libraryguides.neomed.edu/home</a></p> Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Cytoskeletal and mitochondrial-related protein changes within the DBA/2J retinal projection Publisher An entity responsible for making the resource available Investigative Ophthalmology & Visual Science Date A point or period of time associated with an event in the lifecycle of the resource 2016 2016-09 Subject The topic of the resource Ophthalmology Creator An entity primarily responsible for making the resource Wilson G N; Inman D M; Crish S D Identifier An unambiguous reference to the resource within a given context n/a Format The file format, physical medium, or dimensions of the resource Journal Article 2016 Crish S D Department of Pharmaceutical Sciences Inman D M Investigative ophthalmology & visual science Journal Article NEOMED College of Pharmacy Ophthalmology Wilson G N Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. URL Address n/a Rights Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s). Pages 2-2 Issue 7 Volume 56 Search for Full-text Locate full-text within NEOMED Library's e-journal collections <p>Users with a NEOMED Library login can search for full-text journal articles at the following url: <a href="https://libraryguides.neomed.edu/home">https://libraryguides.neomed.edu/home</a></p> Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Cytoskeletal Changes In The Visual Projection Of The Dba/2j Mouse Publisher An entity responsible for making the resource available Investigative Ophthalmology & Visual Science Date A point or period of time associated with an event in the lifecycle of the resource 2015 2015-06 Subject The topic of the resource Ophthalmology Creator An entity primarily responsible for making the resource Crish S D; Lepp J K; Smith M A; Dengler-Crish C M; Wilson G N Identifier An unambiguous reference to the resource within a given context n/a Format The file format, physical medium, or dimensions of the resource Journal Article or Conference Abstract Publication 2015 Crish S D Dengler-Crish C M Department of Pharmaceutical Sciences Investigative ophthalmology & visual science Lepp J K NEOMED College of Pharmacy Ophthalmology Smith M A Wilson G N Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. URL Address <a href="http://doi.org/10.1186/s12974-015-0399-0" target="_blank" rel="noreferrer noopener">http://doi.org/10.1186/s12974-015-0399-0</a> Rights Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s). Pages 13-13 Volume 12 Search for Full-text Locate full-text within NEOMED Library's e-journal collections <p>Users with a NEOMED Library login can search for full-text journal articles at the following url: <a href="https://libraryguides.neomed.edu/home">https://libraryguides.neomed.edu/home</a></p> Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Early pro-inflammatory cytokine elevations in the DBA/2J mouse model of glaucoma Publisher An entity responsible for making the resource available Journal of Neuroinflammation Date A point or period of time associated with an event in the lifecycle of the resource 2015 2015-09 Subject The topic of the resource Aging; axonal-transport; axoplasmic-transport; Cytokines; fibroblast-growth-factor; gene-expression; glaucoma; Immunology; inflammation; Intraocular pressure; Intraocular pressure; necrosis-factor-alpha; neurodegeneration; Neurosciences & Neurology; ocular hypertension; optic-nerve head; retinal ganglion-cells; tnf-alpha Creator An entity primarily responsible for making the resource Wilson G N; Inman D M; Denger-Crish C M; Smith M A; Crish S D Description An account of the resource Background: Neuroinflammation-astrogliosis, microglial activation, and changes in cytokine signaling-is a prominent feature of neurodegenerative disorders. Glaucoma is a group of chronic neurodegenerative conditions that make up the leading cause of irreversible blindness worldwide. Neuroinflammation has been postulated to play a significant role in the pathogenesis and progression of glaucomatous neurodegeneration. Though much is known regarding inflammation in the eye in glaucoma, little is known about cytokine activity outside of the retina where pathologies develop early. Methods: We traced the primary visual projection from the eye to the superior colliculus (SC) in DBA/2J and DBA/2J. Gpnmb(+) (control) mice using the anterograde tracer cholera toxin-B (CTB) to assay axonal transport deficits. Forty-eight hours later, visual structures were microdissected from fresh tissue based on transport outcome. Using magnetic bead multiplexing assays, we measured levels of 20 cytokines in the retina, proximal and distal optic nerves, CTB-positive and negative SC subdivisions, cerebellum, and serum at different ages representing different stages of pathology. Results: Pro-and anti-inflammatory cytokine levels in mice often changed in the same direction based on strain, age, and tissue. Significant elevations in retinal pro-inflammatory cytokines were observed in young DBA/2J mice compared to controls, followed by an age-dependent decrease in the DBA/2J mice. Proximal optic nerve of young DBA/2J mice showed a 50 % or greater decrease in levels of certain cytokines compared to older DBA/2J cohorts and controls, while both proximal and distal optic nerve of DBA/2Js showed elevations in IL-1 beta at all ages compared to controls. Pro-inflammatory cytokine IL-6 levels varied in accordance with transport outcome in the SC: IL-6 was elevated 44-80 % in glaucomatous DBA/2J collicular regions deficient in anterograde transport from retinal ganglion cells (RGCs) compared to areas with intact transport. Conclusion: Dysregulation of cytokine signaling in the RGC projection of DBA/2J mice was evident early in distal retinal targets, well before intraocular pressure elevation or axonal degeneration begins. Identifier An unambiguous reference to the resource within a given context <a href="http://doi.org/10.1186/s12974-015-0399-0" target="_blank" rel="noreferrer noopener">10.1186/s12974-015-0399-0</a> Format The file format, physical medium, or dimensions of the resource Journal Article 2015 Aging axonal-transport axoplasmic-transport Crish S D Cytokines Denger-Crish C M Department of Pharmaceutical Sciences fibroblast-growth-factor gene-expression Glaucoma Immunology Inflammation Inman D M Intraocular Pressure Journal Article Journal of neuroinflammation necrosis-factor-alpha NEOMED College of Pharmacy Neurodegeneration Neurosciences & Neurology Ocular Hypertension optic-nerve head retinal ganglion-cells Smith M A TNF-alpha Wilson G N