1
40
2
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Pages
AP217–AP217
Volume
135
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Parathyroid Hormone is Not Independently Associated With Cognitive Decline: 20 Year Follow-up From the Atherosclerosis Risk in Communities (ARIC) Study.
Publisher
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Circulation
Date
A point or period of time associated with an event in the lifecycle of the resource
2017
2017-03-08
Creator
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Kim Samuel M; Zhao Di; Schneider Andrea L; Korada Sai Krishna; Lutsey Pamela L; Guallar Eliseo; Alonso Alvaro; Windham B Gwen; Gottesman Rebecca F; Michos Erin D
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2017
Alonso Alvaro
Circulation
Gottesman Rebecca F
Guallar Eliseo
Kim Samuel M
Korada Sai Krishna
Lutsey Pamela L
Michos Erin D
Schneider Andrea L
Windham B Gwen
Zhao Di
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1212/WNL.0000000000004290" target="_blank" rel="noreferrer noopener">http://doi.org/10.1212/WNL.0000000000004290</a>
Pages
918–926
Issue
9
Volume
89
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Association of parathyroid hormone with 20-year cognitive decline: The ARIC study.
Publisher
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Neurology
Date
A point or period of time associated with an event in the lifecycle of the resource
2017
2017-08
Subject
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Female; Humans; Male; Middle Aged; Time Factors; Cross-Sectional Studies; Follow-Up Studies; Prospective Studies; Biomarkers/blood; Cognitive Dysfunction/*blood/*epidemiology; Longitudinal Studies; Neuropsychological Tests; Parathyroid Hormone/*blood; Psychological Tests; Human; Cross Sectional Studies; Funding Source; Multicenter Studies; Validation Studies; Comparative Studies; Evaluation Research; Middle Age; Parathyroid Hormones – Blood
Creator
An entity primarily responsible for making the resource
Kim Samuel M; Zhao Di; Schneider Andrea L C; Korada Sai Krishna; Lutsey Pamela L; Guallar Eliseo; Alonso Alvaro; Windham B Gwen; Gottesman Rebecca F; Michos Erin D
Description
An account of the resource
OBJECTIVE: We hypothesized that elevated parathyroid hormone (PTH) levels will be independently associated with 20-year cognitive decline in a large population-based cohort. METHODS: We studied 12,964 middle-aged white and black ARIC participants without a history of prior stroke who, in 1990-1992 (baseline), had serum PTH levels measured and cognitive function testing, with repeat cognitive testing performed at up to 2 follow-up visits. Cognitive testing included the Delayed Word Recall, the Digit Symbol Substitution, and the Word Fluency tests, which were summed as a global Z score. Using mixed-effects models, we compared the relative decline in individual and global cognitive scores between each of the top 3 quartiles of PTH levels to the reference bottom quartile. We adjusted for demographic variables, education, vascular risk factors, and levels of calcium, phosphate, and vitamin D. We imputed missing covariate and follow-up cognitive data to account for attrition. RESULTS: The mean (SD) age of our cohort was 57 (6) years, 57% were women, and 24% were black. There was no cross-sectional association of elevated PTH with cognitive global Z score at baseline (p \textgreater 0.05). Over a median of 20.7 years, participants in each PTH quartile showed a decline in cognitive function. However, there was no significant difference in cognitive decline between each of the top 3 quartiles and the lowest reference quartile (p \textgreater 0.05). In a subset, there was also no association of higher mid-life PTH levels with late-life prevalent adjudicated dementia (p \textgreater 0.05). CONCLUSIONS: Our work does not support an independent influence of PTH on cognitive decline in this population-based cohort study.
Identifier
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<a href="http://doi.org/10.1212/WNL.0000000000004290" target="_blank" rel="noreferrer noopener">10.1212/WNL.0000000000004290</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2017
Alonso Alvaro
Biomarkers/blood
Cognitive Dysfunction/*blood/*epidemiology
Comparative Studies
Cross Sectional Studies
Cross-Sectional Studies
Evaluation Research
Female
Follow-Up Studies
Funding Source
Gottesman Rebecca F
Guallar Eliseo
Human
Humans
Kim Samuel M
Korada Sai Krishna
Longitudinal Studies
Lutsey Pamela L
Male
Michos Erin D
Middle Age
Middle Aged
Multicenter Studies
Neurology
Neuropsychological Tests
Parathyroid Hormone/*blood
Parathyroid Hormones – Blood
Prospective Studies
Psychological Tests
Schneider Andrea L C
Time Factors
Validation Studies
Windham B Gwen
Zhao Di