1 40 1 Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. URL Address <a href="http://doi.org/10.1002/cne.25226" target="_blank" rel="noreferrer noopener">http://doi.org/10.1002/cne.25226</a> ISSN 1096-9861 Search for Full-text Locate full-text within NEOMED Library's e-journal collections <a href="http://neomed.idm.oclc.org/login?url=http://doi.org/10.1002/cne.25226" target="_blank" rel="noreferrer noopener">NEOMED Full-text Holding (if available) - Proxy DOI: 10.1002/cne.25226</a> <p>Users with a NEOMED Library login can search for full-text journal articles at the following url: <a href="https://libraryguides.neomed.edu/home">https://libraryguides.neomed.edu/home</a></p> Update Year & Number August 2021 List NEOMED College NEOMED College of Medicine NEOMED Department Department of Anatomy & Neurobiology Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Tonotopic distribution and inferior colliculus projection pattern of inhibitory and excitatory cell types in the lateral superior olive of Mongolian gerbils. Publisher An entity responsible for making the resource available The Journal of Comparative Neurology Date A point or period of time associated with an event in the lifecycle of the resource 2021 2021-08-02 Subject The topic of the resource auditory; GlyT2; inferior colliculus; lateral superior olive; tonotopy; vGlut2 Creator An entity primarily responsible for making the resource Mellott JG; Dhar M; Mafi A; Tokar N; Winters BD Description An account of the resource Sound localization critically relies on brainstem neurons that compare information from the two ears. The conventional role of the lateral superior olive (LSO) is extraction of intensity differences; however, it is increasingly clear that relative timing, especially of transients, is also an important function. Cellular diversity within the LSO that is not well understood may underlie its multiple roles. There are glycinergic inhibitory and glutamatergic excitatory principal neurons in the LSO, however, there is some disagreement regarding their relative distribution and projection pattern. Here we employ in situ hybridization to definitively identify transmitter types combined with retrograde labeling of projections to the inferior colliculus (IC) to address these questions. Excitatory LSO neurons were more numerous (76%) than inhibitory ones. A smaller proportion of inhibitory neurons were IC-projecting (45% vs. 64% for excitatory) suggesting that inhibitory LSO neurons may have more projections to other regions such the lateral lemniscus or more distributed IC projections. Inhibitory LSO neurons almost exclusively projected ipsilaterally making up a sizeable proportion (41%) of the transmitter type-labeled ipsilateral IC projection from LSO and exhibited a moderate low frequency bias (10% difference H-L). Two thirds of excitatory neurons projected contralaterally and had a slight high frequency bias (4%). One third of excitatory LSO neurons projected ipsilaterally to the IC and these cells were strongly biased toward the low frequency limb of the LSO (37%). This projection appears to be species specific in animals with good low frequency hearing suggesting that this may be a specialization for such ability. This article is protected by copyright. All rights reserved. (© 2021 Wiley Periodicals, Inc.) Identifier An unambiguous reference to the resource within a given context <a href="http://doi.org/10.1002/cne.25226" target="_blank" rel="noreferrer noopener">10.1002/cne.25226</a> Rights Information about rights held in and over the resource Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s). Format The file format, physical medium, or dimensions of the resource journalArticle 2021 Auditory August 2021 List Department of Anatomy & Neurobiology Dhar M GlyT2 inferior colliculus journalArticle lateral superior olive Mafi A Mellott JG NEOMED College of Medicine The Journal of comparative neurology Tokar N tonotopy VGLUT2 Winters BD