1
40
4
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Text
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URL Address
<a href="http://doi.org/10.1200/jco.2005.04.3273" target="_blank" rel="noreferrer noopener">http://doi.org/10.1200/jco.2005.04.3273</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
2028-2037
Issue
13
Volume
24
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Title
A name given to the resource
Prognosis after ipsilateral breast tumor recurrence and locoregional recurrences in five national surgical adjuvant breast and bowel project node-positive adjuvant breast cancer trials
Publisher
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Journal of Clinical Oncology
Date
A point or period of time associated with an event in the lifecycle of the resource
2006
2006-05
Subject
The topic of the resource
20-year follow-up; conservative surgery; conserving therapy; doxorubicin-cyclophosphamide; european organization; local recurrence; Oncology; radiation-therapy; randomized-trial; risk-factors; stage-i
Creator
An entity primarily responsible for making the resource
Wapnir I L; Anderson S J; Mamounas E P; Geyer C E; Jeong J H; Tan-Chiu E; Fisher B; Wolmark N
Description
An account of the resource
Purpose Locoregional failure after breast-conserving surgery is associated with increased risk of distant disease and death. The magnitude of this risk in patients receiving chemotherapy has not been adequately characterized. Patients and Methods Our study population included 2,669 women randomly assigned onto five National Surgical Adjuvant Breast and Bowel Project node-positive protocols (B-15, B-16, B-18, B-22, and B-25), who were treated with lumpectomy, whole-breast irradiation, and adjuvant systemic therapy. Cumulative incidences of ipsilateral breast tumor recurrence (IBTR) and other locoregional recurrence (oLRR) were calculated. Kaplan-Meier curves were used to estimate distant-disease-free survival (DDFS) and overall survival (OS) after IBTR or oLRR. Cox models were used to model survival using clinical and pathologic factors jointly with IBTR or oLRR as time-varying predictors. Results Four hundred twenty-four patients (15.9%) experienced locoregional failure; 259 (9.7%) experienced IBTR, and 165 (6.2%) experienced oLRR. The 10-year cumulative incidence of IBTR and oLRR was 8.7% and 6.0%, respectively. Most locoregional failures occurred within 5 years (62.2% for IBTR and 80.6% for oLRR). Age, tumor size, and estrogen receptor status were significantly associated with IBTR. Nodal status and estrogen and progesterone receptor status were significantly associated with oLRR. The 5-year DDFS rates after IBTR and oLRR were 51.4% and 18.8%, respectively. The 5-year OS rates after IBTR and oLRR were 59.9% and 24.1%, respectively. Hazard ratios for mortality associated with IBTR and oLRR were 2.58 (95% CI, 2.11 to 3.15) and 5.85 (95% CI, 4.80 to 7.13), respectively. Conclusion Node-positive breast cancer patients who developed IBTR or oLRR had significantly poorer prognoses than patients who did not experience these events.
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An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1200/jco.2005.04.3273" target="_blank" rel="noreferrer noopener">10.1200/jco.2005.04.3273</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article
20-year follow-up
2006
Anderson S J
conservative surgery
conserving therapy
doxorubicin-cyclophosphamide
european organization
Fisher B
Geyer C E
Jeong J H
Journal Article
Journal of Clinical Oncology
local recurrence
Mamounas E P
oncology
radiation-therapy
randomized-trial
risk-factors
stage-i
Tan-Chiu E
Wapnir I L
Wolmark N
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1200/jco.2006.06.9054" target="_blank" rel="noreferrer noopener">http://doi.org/10.1200/jco.2006.06.9054</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
3927-3932
Issue
24
Volume
24
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Title
A name given to the resource
Low locoregional recurrence rate among node-negative breast cancer patients with tumors 5 cm or larger treated by mastectomy, with or without adjuvant systemic therapy and without radiotherapy: Results from five National Surgical Adjuvant Breast and Bowel Project randomized clinical trials
Publisher
An entity responsible for making the resource available
Journal of Clinical Oncology
Date
A point or period of time associated with an event in the lifecycle of the resource
2006
2006-08
Subject
The topic of the resource
chemotherapy; irradiation; Oncology; postmastectomy radiotherapy; postoperative radiotherapy; premenopausal women; radiation-therapy; receptor-positive tumors; risk-factors; sequential methotrexate; tamoxifen
Creator
An entity primarily responsible for making the resource
Taghian A G; Jeong J H; Mamounas E P; Parda D S; Deutsch M; Costantino J P; Wolmark N
Description
An account of the resource
Purpose Lymph node (LN)-negative breast cancer tumors >= 5 cm occur infrequently, and their optimal management is not well defined. In this study, we assess patterns of locoregional failure (LRF) in LN-negative patients who underwent mastectomy, either with or without adjuvant chemotherapy or hormonal therapy and without postmastectomy radiation therapy (PMRT). Patients and Methods Of 8,878 breast cancer patients enrolled onto National Surgical Adjuvant Breast and Bowel Project B-13, B-14, B-19, B-20, and B-23 node-negative trials, 313 had tumors that were 5 cm or larger (median, 5.5 cm; range, 5.0 to 15.5 cm) at pathology and were treated by mastectomy. Median follow-up time was 15.1 years. Therapy included adjuvant chemotherapy in 34.2% of patients; tamoxifen in 21.1%; chemotherapy plus tamoxifen in 19.2%; and no systemic therapy in 25.5%. Results Twenty-eight patients experienced LRF. The overall 10-year cumulative incidences of isolated LRF, LRF with and without distant failure (DF) and DF alone as first event were 7.1%, 10.0%, and 23.6%, respectively. cumulative incidences for isolated LRF as first event for patients with tumors of 5 cm or more than 5 cm were 7.0% and 7.2%, respectively (P=.9). For patients who underwent no systemic treatment, chemotherapy alone, tamoxifen alone, of chemotherapy plus tamoxifen, the incidences were 12.6%, 5.6%, 4.6%, and 5.3%, respectively (P=.2). The majority of failures occurred on the chest wall (24 of 28 patients). Multivariate analysis did not identify significant prognostic factors for LRF. Conclusion In patients with LN-negative tumors >= 5 cm who are treated by mastectomy with or without adjuvant systemic therapy and no PMRT, LRF as first event remains low. PMRT should not be routinely used for these patients.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1200/jco.2006.06.9054" target="_blank" rel="noreferrer noopener">10.1200/jco.2006.06.9054</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article
2006
Chemotherapy
Costantino J P
Deutsch M
irradiation
Jeong J H
Journal Article
Journal of Clinical Oncology
Mamounas E P
oncology
Parda D S
postmastectomy radiotherapy
postoperative radiotherapy
premenopausal women
radiation-therapy
receptor-positive tumors
risk-factors
sequential methotrexate
Taghian A G
Tamoxifen
Wolmark N
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1200/jco.2007.15.0235" target="_blank" rel="noreferrer noopener">http://doi.org/10.1200/jco.2007.15.0235</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
778-785
Issue
5
Volume
26
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Dublin Core
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Title
A name given to the resource
Preoperative chemotherapy: Updates of National Surgical Adjuvant Breast and Bowel Project Protocols B-18 and B-27
Publisher
An entity responsible for making the resource available
Journal of Clinical Oncology
Date
A point or period of time associated with an event in the lifecycle of the resource
2008
2008-02
Subject
The topic of the resource
cancer patients; chemotherapy; competing risk; conservative treatment; estrogen-receptor status; expressing estrogen; induction; multimodal; neoadjuvant chemotherapy; Oncology; radiation-therapy; treatment; tumor response
Creator
An entity primarily responsible for making the resource
Rastogi P; Anderson S J; Bear H D; Geyer C E; Kahlenberg M S; Robidoux A; Margolese R G; Hoehn J L; Vogel V G; Dakhil S R; Tamkus D; King K M; Pajon E R; Wright M J; Robert J; Paik S; Mamounas E P; Wolmark N
Description
An account of the resource
Purpose National Surgical Adjuvant Breast and Bowel Project (NSABP) Protocol B-18 was designed to determine whether four cycles of doxorubicin and cyclophosphamide (AC) administered preoperatively improved breast cancer disease-free survival (DFS) and overall survival (OS) compared with AC administered postoperatively. Protocol B-27 was designed to determine the effect of adding docetaxel (T) to preoperative AC on tumor response rates, DFS, and OS. Patients and Methods Analyses were limited to eligible patients. In B-18, 751 patients were assigned to receive preoperative AC, and 742 patients were assigned to receive postoperative AC. In B-27, 784 patients were assigned to receive preoperative AC followed by surgery, 783 patients were assigned to AC followed by T and surgery, and 777 patients were assigned to AC followed by surgery and then T. Results Results from B-18 show no statistically significant differences in DFS and OS between the two groups. However, there were trends in favor of preoperative chemotherapy for DFS and OS in women less than 50 years old (hazard ratio [HR] = 0.85, P = .09 for DFS; HR = 0.81, P = .06 for OS). DFS conditional on being event free for 5 years also demonstrated a strong trend in favor of the preoperative group (HR = 0.81, P = .053). Protocol B-27 results demonstrated that the addition of T to AC did not significantly impact DFS or OS. Preoperative T added to AC significantly increased the proportion of patients having pathologic complete responses (pCRs) compared with preoperative AC alone (26% v 13%, respectively; P < .0001). In both studies, patients who achieved a pCR continue to have significantly superior DFS and OS outcomes compared with patients who did not. Conclusion B-18 and B-27 demonstrate that preoperative therapy is equivalent to adjuvant therapy. B-27 also showed that the addition of preoperative taxanes to AC improves response.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1200/jco.2007.15.0235" target="_blank" rel="noreferrer noopener">10.1200/jco.2007.15.0235</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article
2008
Anderson S J
Bear H D
Cancer Patients
Chemotherapy
competing risk
conservative treatment
Dakhil S R
estrogen-receptor status
expressing estrogen
Geyer C E
Hoehn J L
induction
Journal Article
Journal of Clinical Oncology
Kahlenberg M S
King K M
Mamounas E P
Margolese R G
multimodal
neoadjuvant chemotherapy
oncology
Paik S
Pajon E R
radiation-therapy
Rastogi P
Robert J
Robidoux A
Tamkus D
Treatment
tumor response
Vogel V G
Wolmark N
Wright M J
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1200/jco.2006.09.3849" target="_blank" rel="noreferrer noopener">http://doi.org/10.1200/jco.2006.09.3849</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
1-1
Issue
18
Volume
25
Search for Full-text
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Updated results of the combined analysis of NCCTG N9831 and NSABP B-31 adjuvant chemotherapy with/without trastuzumab in patients with HER2-positive breast cancer
Publisher
An entity responsible for making the resource available
Journal of Clinical Oncology
Date
A point or period of time associated with an event in the lifecycle of the resource
2007
2007-06
Subject
The topic of the resource
Oncology
Creator
An entity primarily responsible for making the resource
Perez E A; Romond E H; Suman V J; Jeong J; Davidson N E; Geyer C E; Martino S; Mamounas E P; Kauffman P A; Wolmark N
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1200/jco.2006.09.3849" target="_blank" rel="noreferrer noopener">10.1200/jco.2006.09.3849</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article
2007
Davidson N E
Geyer C E
Jeong J
Journal Article
Journal of Clinical Oncology
Kauffman P A
Mamounas E P
Martino S
oncology
Perez E A
Romond E H
Suman V J
Wolmark N