1
40
3
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1046/j.1524-475x.2003.11208.x" target="_blank" rel="noreferrer noopener">http://doi.org/10.1046/j.1524-475x.2003.11208.x</a>
Pages
127–131
Issue
2
Volume
11
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Effects of vascular endothelial growth factor on wound closure rates in the genetically diabetic mouse model.
Publisher
An entity responsible for making the resource available
Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society
Date
A point or period of time associated with an event in the lifecycle of the resource
2003
2003-04
Subject
The topic of the resource
Administration; Angiogenesis Inducing Agents/*administration & dosage; Animal; Animals; Diabetes Mellitus/*physiopathology; Endothelial Growth Factors/*administration & dosage; Intercellular Signaling Peptides and Proteins/*administration & dosage; Lymphokines/*administration & dosage; Mice; Models; Topical; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors; Wound Healing/*drug effects
Creator
An entity primarily responsible for making the resource
Kirchner Loren M; Meerbaum Sharon O; Gruber Brian S; Knoll Andrew K; Bulgrin Jeffery; Taylor R A J; Schmidt Steven P
Description
An account of the resource
Impaired wound healing is characteristic of diabetic patients. Potential reasons include poor inflammatory response, granulation tissue formation, and abnormal patterns of cytokine release and response. Vascular endothelial growth factor, abnormally regulated during healing in diabetics, is the major factor stimulating angiogenesis during normal wound healing. We tested our hypothesis that topically applied vascular endothelial growth factor would improve wound closure rates in diabetic animals in a full-thickness wound model in genetically diabetic mice (C57 BL/KsJ db/db). Animals received either 1.0 micro g of vascular endothelial growth factor165 or polyethylene glycol alone topically to wounds daily between days 0 and 4 post-wounding. Wound area was measured at days 0, 5, 10, 15, and 21. Data were analyzed using probit analysis and expressed as length-of-time (LT) to 50, 90, and 95% wound closure. Among untreated animals, nondiabetics had an LT50 of 8.5 days (fiducial limits 8.3-8.7), while diabetics had an LT50 of 15.8 days (15.6-16.1). Vascular endothelial growth factor-treated animals had LT50 values of 7.8 (7.6-8.1) and 11.8 days (11.6-12.0) for nondiabetics and diabetics, respectively, representing a 25% improvement in time to 50% closure in treated diabetics. We conclude that topically applied vascular endothelial growth factor improves time to wound closure in the genetically diabetic mouse model.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1046/j.1524-475x.2003.11208.x" target="_blank" rel="noreferrer noopener">10.1046/j.1524-475x.2003.11208.x</a>
Rights
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2003
Administration
Angiogenesis Inducing Agents/*administration & dosage
Animal
Animals
Bulgrin Jeffery
College of Graduate Studies
Department of Pharmaceutical Sciences
Diabetes Mellitus/*physiopathology
Endothelial Growth Factors/*administration & dosage
Gruber Brian S
Intercellular Signaling Peptides and Proteins/*administration & dosage
Kirchner Loren M
Knoll Andrew K
Lymphokines/*administration & dosage
Meerbaum Sharon O
Mice
Models
NEOMED College of Graduate Studies
NEOMED College of Pharmacy
Schmidt Steven P
Taylor R A J
Topical
Vascular Endothelial Growth Factor A
Vascular Endothelial Growth Factors
Wound Healing/*drug effects
Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/s0002-9378(97)70606-9" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/s0002-9378(97)70606-9</a>
Pages
819–23; discussion 823–825
Issue
4
Volume
176
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
The effect of intermittent-release intraperitoneal chemotherapy on wound healing.
Publisher
An entity responsible for making the resource available
American journal of obstetrics and gynecology
Date
A point or period of time associated with an event in the lifecycle of the resource
1997
1997-04
Subject
The topic of the resource
Animals; Antineoplastic Agents/administration & dosage/*pharmacology; Carboplatin/administration & dosage/*pharmacology; Infusions; Laparotomy; Male; Paclitaxel/administration & dosage/*pharmacology; Parenteral; Rats; Sprague-Dawley; Tissue Adhesions/chemically induced; Wound Healing/*drug effects
Creator
An entity primarily responsible for making the resource
Hopkins M P; von Gruenigen V E; Holda S; Weber B
Description
An account of the resource
OBJECTIVE: Our purpose was to study the effect on wound healing when intraperitoneal chemotherapy was instilled on a daily basis. STUDY DESIGN: Intraperitoneal carboplatin, Taxol, or saline solution was instilled daily into 70 rats after they underwent laparotomy. The animals were killed and analyzed for adhesions. An area measuring 5 x 5 cm including the incision was also harvested for biomechanical testing. The wound thickness was measured, and the Shore Western Materials Testing System (Monrovia, Calif.) was used to test the force required to break the wound, the stress, and the stiffness. RESULTS: Groups of 10 rats received saline solution control, carboplatin 6 mg/kg, 7 mg/kg, 8 mg/kg, or Taxol 2.5 mg/kg, 3.0 mg/kg, or 3.5 mg/kg. The total dose was divided into seven equal amounts, administered daily. No significant adhesions developed in any of the animals. The carboplatin group experienced no significant decrease in wound thickness whereas the higher-dose Taxol group had a significant decrease in thickness from 1.06 mm to 0.72 mm (p = 0.02). The wound-breaking strength (force) also decreased for the highest-dose Taxol group from 710 gm to 411 gm (p = 0.02). The wound stiffness was also decreased from 69 gm/mm to 46 gm/mm (p = 0.01). The other measured parameters for both the Taxol and carboplatin groups were not significantly decreased when compared with those of controls. CONCLUSION: The immediate instillation of divided daily carboplatin did not influence wound strength whereas the use of Taxol on a similar schedule significantly decreased wound strength.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/s0002-9378(97)70606-9" target="_blank" rel="noreferrer noopener">10.1016/s0002-9378(97)70606-9</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1997
American journal of obstetrics and gynecology
Animals
Antineoplastic Agents/administration & dosage/*pharmacology
Carboplatin/administration & dosage/*pharmacology
Holda S
Hopkins M P
Infusions
Laparotomy
Male
Paclitaxel/administration & dosage/*pharmacology
Parenteral
Rats
Sprague-Dawley
Tissue Adhesions/chemically induced
von Gruenigen V E
Weber B
Wound Healing/*drug effects
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1006/gyno.1993.1274" target="_blank" rel="noreferrer noopener">http://doi.org/10.1006/gyno.1993.1274</a>
Pages
210–213
Issue
2
Volume
51
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
The effect of immediate intraperitoneal carboplatinum on wound healing.
Publisher
An entity responsible for making the resource available
Gynecologic oncology
Date
A point or period of time associated with an event in the lifecycle of the resource
1993
1993-11
Subject
The topic of the resource
Animals; Carboplatin/*administration & dosage/pharmacology; Dose-Response Relationship; Drug; Injections; Intraperitoneal; Male; Postoperative Period; Rats; Sprague-Dawley; Tissue Adhesions/etiology; Wound Healing/*drug effects
Creator
An entity primarily responsible for making the resource
Hopkins M P; Shellhaas C; Clark T; Stakleff K S; Jenison E L
Description
An account of the resource
The effect of introducing intraperitoneal carboplatinum on wound healing immediately after wound closure was studied using a rat model. All animals were opened through a midline incision. A bowel anastomosis was then performed in a single-or two-layer fashion using 6-O suture. Immediately after closing the abdominal wall, each animal was percutaneously injected with either normal saline for controls (n = 11), or carboplatinum, 3 (n = 8), 9, (n = 19, or 12 mg/kg (n = 4). Abdominal and skin incisions were closed separately using 4-O silk suture. Animals were sacrificed 7 days postoperatively. Adhesions were blindly assessed on the following scale: 0 (no adhesions), 1 (filmy adhesions), 2 (firm adhesions), and 3 (dense adhesions). Anastomoses were assessed for leakage. Three centimeters of the incision were harvested to evaluate wound breaking strength. Analysis of abdominal wound breaking strengths showed control = 1320 g +/- 220, 3 mg = 1055 g +/- 155, 9 mg = 891 g +/- 127, and 12 mg = 594 g +/- 165 (P \textless 0.025). Evaluation for dense adhesions resulted in control = 27%, 3 mg/kg = 50%, 9 mg = 63%, and 12 mg = 100% (P \textless 0.0001). Immediate instillation of intraperitoneal carboplatinum had a significant effect on wound healing with a decrease in abdominal tensile strength directly related to the dose instilled. It also had a significant effect on adhesion formation with a higher dose leading to a higher incidence of adhesion formation. Based on animal model data, it appears that the immediate instillation of intraperitoneal carboplatinum at the time of laparotomy incision closure could lead to significant problems with wound strength and adhesion formation.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1006/gyno.1993.1274" target="_blank" rel="noreferrer noopener">10.1006/gyno.1993.1274</a>
Rights
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1993
Animals
Carboplatin/*administration & dosage/pharmacology
Clark T
Dose-Response Relationship
Drug
Gynecologic oncology
Hopkins M P
Injections
Intraperitoneal
Jenison E L
Male
Postoperative Period
Rats
Shellhaas C
Sprague-Dawley
Stakleff K S
Tissue Adhesions/etiology
Wound Healing/*drug effects